OB-GYNE

Question 1

Triad of McCune Albright Syndrome

Answer 1

Pigment - Cafe au lait spots
Pockets - cysts of skull and long bones
Pilyostotic - fibrous dysplasia

*G3 mutation -> adenylate cyclase activation –> inc FSH, LH, TSH, GH

Question 2

GnRH dependent precocious puberty drug of choice:

Answer 2

GnRG Agonist (LEUPROLIDE)
*via negative feedback

Question 3

Rotterdam Criteria for PCOS

Answer 3

2 of the ff:

1. Menstrual irregularity
2. Hyperandrogenism
3. UTZ - PCO

Question 4

Acquired uterine adhesions secondary to frequent D&C or curettage leading to infertility

Answer 4

Asherman syndrome

Question 5

First line treatment for Anovulation:

competes with estrogen binding in hypothalamus -> Inc. FSH & E2

Answer 5

Clomiphene citrate

Question 6

Absolute contraindication for HRT in post menopausal women

Answer 6

Pophyria cutanei tarda ( skin photosensitivity)

Question 7

Meig Syndrome

Answer 7

1. ovarian fibroma
2. ascites
3. hydrothorax

Question 8

Transitional cell tumor of the ovary with a “coffee-bean” nucleus

Answer 8

Brenner tumor

Question 9

Hobnail cells are seen in?

Answer 9

Clear cell Ovarian tumor

*cell with abundant glycogen
Assoc with DES exposure

Question 10

Malignant germ cell tumor

+) schiller duval bodies (hyaline droplets

Answer 10

Endodermal sinus tumor/ Yolk sac tumor

*tumor marker: AFP

Question 11

Sex cord tumor with Call-Exner Bodies

*coffee bean nuclei arranged in small clusters around a central cavity

Answer 11

Granulosa Theca Cell Tumor