OBGYN

Question 1

Endometrial carcinoma

Answer 1

1- Ultramutated: DNA polymerase
2- Hypermutated: MSI -> mutation in MMR
3- Copy number high: TP53
4- Copy number low in obese people

Question 2

Serous carcinoma

Answer 2

Mol: TP53, PPP2R1A, PIK3CA, HER2
IHC: p53 variation, HER2 30%, p16 block positivity.

Question 3

Clear cell carcinoma

Answer 3

Looks like clear cells.
IHC: p16 patchy, HNF-1beta, NapsinA, p53 can be wild, mutant or aberrant.

Question 4

Mucinous carcinoma

Answer 4

KRAS mutation.
Can have goblet cells, CDX2 positive.
CK7, CK20, MUC6, PAX8.

Question 5

Undifferentiated carcinoma

Answer 5

MMR deficient: IHC MLH1/PMS2 loss
SMARCA4 mutation: BRG1 loss (If smart is lost then bridge is lost)
Loss/focal: AE1/AE3, EMA, ER/PR, PAX8.

Question 6

Leiomyosarcoma

Answer 6

Tumor type necrosis with abrupt transition

TP53, RB1, ATRX, HMGA2

Question 7

Endometrial stromal nodule

Answer 7

Suzzie likes jazz; JAZF1-SUZ12 fusion (7;17)
CD10, ER, PR, VIMENTIN