Odd stuff 3

Question 1

What is Bortezomib and carfilzomib used for?

Answer 1

proteasome inhibitors, induce arrest at G2-M, apoptosis, not in sketchy

Question 2

What is Trastuzumab used for?

What two cancers are we used in?

Answer 2

Monoclonal antibody against HER 2, a tyrosine kinase receptor, tapestry weaver

Gastric and Breast Cancer

Question 3

What is the Vemurafenib used for?

Answer 3

Small molecule inhibitor of BRAF oncogene melanoma, “venom” on the “Dont tread on me” flag, Multiple Myeloma

Question 4

What is Rasburicase used for?

Answer 4

synthetic move from uric acid to allantoin, not in sketchy

Question 5

Sunitinib and Soratinib inhibit what? They are not in First Aid, sketchy only

Answer 5

VEGF, flowers in the sketchy video, can be used in RCC

Question 6

What does BAX and BAK are what? What does Bcl-2 and BCL-x are what?

Answer 6

proapoptotic antiapoptotic

Question 7

What immunosuppresant drug blocks calcineurin, prevents IL-2 transcription?

What is a problem with it?

Answer 7

cyclosporine

gingival hyperplasia, nephrotoxic

Question 8

What immunosuppresant drug blocks FK506, preventing IL-2 transcription?

What is good about it?

Answer 8

Tacrolimus

No nephrotoxicity, no gingival hyperplasia, and no neurotoxicity

Question 9

What immunosupressant hits mTOR, blocks mTOR and is not nephrotoxic?

Answer 9

Sirolimus (Rapamycin), not nephrotoxic

Question 10

What -mab blocks IL-2R?

Answer 10

Basiliximab

Question 11

When a graft is from yourself, what is it?

Answer 11

autograft

Question 12

When a graft is from an identical twin or clone?

Answer 12

Isograft

Question 13

When a graft is from a non-identical individual of same species?

Answer 13

Allograft

Question 14

What a graft is from a different species, what is it?

Answer 14

Xenograft

Question 15

What toxin is from a pufferfish? What is the MOA?

Answer 15

Tetrodotoxin, binds fast voltage-gated Na+, prevents depolarization

Question 16

What toxin is from a reef fish such as a barracuda, snapper, and moray eel?

Answer 16

Opens Na channels, depolarization Ciguatoxin

Question 17

What toxin is from a dark meat fish, such as tuna, mahi mahi? What is the MOA?

Answer 17

Histamine bacterial histidine decarboxylase prevents histidine to histamine, usually misdiagonsed as a fish allergy

Question 18

What -mab rapidly reverses Dagtroban?

Answer 18

Idarucizumab

Question 19

When we have anemia, and we want to stimulate/have an increase in erythopoietin, what drug do we give?

Answer 19

Epoetin alfa

Question 20

What drug increases granulocytes?

What drug increases monocyte counts too?

Answer 20

Filgrastim

Sargramostim

Question 21

What is a Romiplostim?

What is an eltrombopag?

Answer 21

TPO analog

TPO receptor agonist

Question 22

When D1 is stimulated, what is the MOA, via the G(s) pathway?

Answer 22

Relaxes renal vascular smooth muscle

Question 23

When there is D2 agonist, G(i), what is the MOA, non psych stuff?

Answer 23

Modulates transmitter release, especially in brain

Question 24

What is the ending for -ximab mean?

Answer 24

Chimeric human-mouse monoclonal Ab

Question 25

What does the ending of -zumab, stand for?

Answer 25

Humanized mouse monoclonal antibody

Question 26

What does human monoclonal antibody -umab?

Answer 26

Human monoclonal Antibody

Question 27

What does the ending -tinib inhibit?

Answer 27

tyrosine kinase inhibitor

Question 28

What does -zomib inhibit?

Answer 28

Proteasome inhibitor

Question 29

What does the -ciclib inhibit?

Answer 29

cyclin-dependent kinase inhibitor

Question 30

What does the ending of -cept stand for?

Answer 30

TNF-alpha antagonist

Question 31

What does the ending -leukin stand for or go after?

Answer 31

IL-2 agonist/analog

Question 32

What does the ending of -kinra stand for work on?

Answer 32

Interluekin receptor antagonist

Question 33

In the world of Hep C drugs: What inhibits NS5A, a viral phosphoprotein that plays a key role in RNA replication?

Answer 33

Ledipasvir and Ombitasvir "North Sea in Sketchy"

Question 34

In the world of Hep C: What inhibits NS5B, and RNA dependent RNA polymerase acting as a chain terminator?

Answer 34

Sofosbuvir and Dasabuvir THis is the sofa couch in sketchy

Question 35

What inhibits NS3/4A a viral protease preventing viral replication?

Answer 35

Grazoprevir and Simeprevir This is the "stuck machette" in sketchy

Question 36

What is/are the side effects of Grazoprevir Simeprevir ?

Answer 36

Grazoprevir: Photosensitivity reactions (camera) Simeprevir: Headache and Fatigue

Question 37

What disease is CA 15-3/CA 27-29?

Answer 37

Breast Cancer

Question 38

What disease is CA 19-9?

Answer 38

Pancreatic adenocarcinoma

Question 39

What disease is CA 125?

Answer 39

Ovarian Cancer

Question 40

What does Good Syndrome have?

Answer 40

Hypogammaglobulinemia, there is a B cell and T cell immunodeficiency

Question 41

What does migratory superficial thrombophelbitis show up in?

Answer 41

Trousseau Syndrome

Question 42

What nonbacterial thrombotic endocarditis have that can lead to adenocarcinomas, especially pancreatic?

Answer 42

Nonbacterial Thrombotic Endocarditis Deposition of sterile platelet thrombi on heart valves

Question 43

What is anti-NMDA receptor encephalitis show up in?

Answer 43

Ovarian teratoma, not in sketchy

Question 44

What does neuroblastoma and small cell lung cancer diseases cause?

Answer 44

Opsoclonus-myoclonus ataxia syndrome

Question 45

What disease has anti-Hu antibodies? name 2

Answer 45

Small Cell Lung Cancer and paraneoplastic encephalomyelitis

Question 46

What disease has anti-Yo antibodies?

Answer 46

OBGYN and Breast Cancer

Question 47

What disease has anti-Tr antibodies?

Answer 47

Hodgkin Lymphoma

Question 48

What stains positive for cytokeratin?

Answer 48

SCC Epithelial cells

Question 49

Error of morphogenesis: Absent organ due to absent primordial tissue

Answer 49

Agenesis

Question 50

Error of morphogenesis: Absent organ despite presence of primordial tissue

Answer 50

Aplasia

Question 51

Error of morphogenesis: Incomplete organ development; primordial tissue present

Answer 51

Hypoplasia