Onco Flashcards
(8 cards)
Most common Tumor in Li-Fraumeni syndrome
- Sarcoma soft tissue
- Osteosarcoma
- Breast cancer
- Brain tumors
- Leukaemia
Breast
Genes which can be mutated in Li-Fraumeni syndrome
- Tp53
- CHK1
- CHK2
- All of the above
All
Most important carcinogen -
Uv a
Uv b
Uv c
Uv a 320-400 nm
Uv b 280-320
Uv c 200-280
But uv c is filtered out
So uv b is most important
Which of the following statements is true
- Low dose ionising radiation exposure increases risk for development of cancer
- High dose ionising radiation exposure slows Tumor growth
- Both are true
- Both are false
Both are true
Arrange in order of increasing radio resistance
- Git
- Hematopoietic cells
- Thyroid
- Lung
Most vulnerable
Hematopoetic cells > thyroid
Intermediate
Breast, lung, salivary gland
Resistant
Skin, bone, GiT
True about GIST
A. Lymph node Mets present in KIT positive GiST
B. Lymph node Mets present in PDGFRA positive GiST
C. Lymp node Mets present in Wild type GiST
D. Gist is ass with NF-2
Associated with NF1
Order of appearance of the cells in wound
- Lymphocytes
- Fibroblasts
- Macrophages
- Neutrophils
Neutrophils - 2 day
Macrophages - day 3
Fibroblasts
Lymphocytes - day 7
True about GIST is all except
A. May arise in retroperitoneum
B. Epitheloid cell GiST more common in small intestine
C. All GIST’s are considered malignant
D. Gain of function mutation in chromosome 4 found in 80%
Gist <2 cm am considered benign
