Onco Pharm

Question 1

Antica drugs causing Pulm fibrosis

Answer 1

1. Bleomycin (free radical damage)

2. Busulfan (DNA cross linking)

Question 2

DNA cross linkers / Alkylating agents

Answer 2

PNBC

1. Procarbazine (Hodgkin)
2. Nitrosureas (brain ca)
3. Bleomycin (testicular + Hodgkin)
4. Cyclophosphamide (leukemia + SLE)

Question 3

Anti metabolites or purine/ pyrimidime analogs

Answer 3

5MAC

1. 5FU (inc effect w Leucorvin) py
2. Methotrexate (DHF reductase inhib)
3. Azathioprine pu
4. Cladribine pu
5. Cytarabine py

Question 4

Antitumor Abx

Answer 4

1. Bleomycin
2. Anthracyclines
3. Dactinomycin

Question 5

S phase inhibitors

Answer 5

1. Methotrexate
2. 5FU
3. Hydroxyurea

*Sushi phase restaurant

Question 6

Purine inhibitors

Answer 6

1. Azathioprine/ 6MP
2. Allopurinol
3. Mycophenolate mofetil

*hunchback of notre DNA

Question 7

DNA polymerase inhibitors

Answer 7

Also S phase inhibitors

1. Cladribine pu (Hairy cell leukemia)
2. Cytarabine py
3. Gemcitabine py