Phys

Question 1

Hb electrophoresis

Answer 1

A Fat Santa can’t go far

farthest: HbA > HbF > HbS

From cathode (+) to anode (-)

Question 2

Platelet plug formation/ 1° hemostasis

Answer 2

1. Endothelial injury : endothelin: vasoconstriction
2. Exposure: vWF (Weibel-Palade bodies & a-granules) exposed to collagen
3. Adhesion: vWF (GpIb) + platelet = latelet release Ca2+ & ADP (coag cascade) & TXA2
4. Activation: ADP adheres platelet to endoth + induction on GpIIb/IIIa on surface, via P2Y12 receptor
5. Aggregation: Fibrinogen + platelet

Temp platelet plug, stops bleeding : unstable :: coag cascade 2° hemostasis

Question 3

TXA2

Inhibited by

Answer 3

Platelet aggregator
Dec blood flow

Aspirin

Question 4

Expr of ADP induced GpIIb/IIIa inhib by

Answer 4

Clopidogrel
Ticlopidine
Parasugrel

Question 5

Direct GpIIb/IIIa inhibitors

Answer 5

Abciximab
Eptifibatide
Tirofiban

Question 6

What activates vWF to bind to GpIb ?

Answer 6

Ristocetin

Question 7

Intrinsic pathway of coagulation

Answer 7

Contact activation

XII
XI
IX
VII

PTT
Heparin
Slower

Question 8

Extrinsic pathway of coagulation

Answer 8

Tissue factor

VII

PT
Warfarin
Faster

Question 9

What activates Bradykinin

Answer 9

Kallikrein

Question 10

Regulatory anticoagulant proteins

Answer 10

Proteins C & S

Question 11

Anticoagulants

Answer 11

LMWH
heparin
Fondaparinaux

Question 12

Antithrombin: Direct Xa inhib

Answer 12

Apixaban

Question 13

Antithrombin: Direct thrombin (IIa) inhib

Answer 13

Argatroban
Bivalirudin
Dabigatran

Question 14

Thrombolytics

+TPA

Answer 14

Alteplase
Reteplase
Streptokinase
Tenecteplase

Question 15

Antifibrinolytics

-tPA

Answer 15

Aminocaproic acid

Tranexamic acid

Question 16

Fibrin degradation product

Answer 16

D-dimers

Question 17

Vit K dep synthesis

Answer 17

Factors II, VII, IX, X

Proteins C &S

Question 18

Epoxide reducatase

f
Inhibitor

Answer 18

Inactive (ox) Vit K to active (reduced) Vit k

Inhib by Warfarin

Question 19

What reverses action of Warfarin?

Answer 19

Vit k
FFP
PCC

Question 20

vWF synth by

Answer 20

Endoth cells in response to injury & megakaryocytes

Question 21

Clock face chromatin

Answer 21

Plasma cells

Question 22

Cell cycle + checkpoints

Answer 22

G0: resting

Interphase : preps for division
G1 : synth of RNA, protein, lipid n CHO
S: DNA replication 
G2: ATP synth
M: mitosis : 2 daughter cells

Checkpoints: ret by cycling n CDK.

G1→S checkpoint reg by HYPOphosphorylated (active) Rb

Question 23

BT
PT
PTT
TT
INR

Answer 23

BT: 2-7 min

PT: 11-15 sec

PTT: 25-40 sec

TT: <2 sec

INR: 2-3 (Warfarin)

Question 24

Hemostasis glycoproteins synth by endoth cells and megakaryocytes?

Answer 24

vWF