onco/tumor suppressor genes Flashcards
(27 cards)
1
Q
ALK
A
- RTK
- lung adenoCA
2
Q
EGFR (ERBB1)
A
- RTK
- lung adenoCA
3
Q
HER2
A
- RTK
- breast & gastric CA
4
Q
RET
A
- RTK
- MEN 2A & 2B, medullary & papillary thyroid CA, pheochromocytoma
5
Q
BCR-ABL
A
- non RTK
- CML, ALL
6
Q
JAK2
A
- non RTK
- myeloproliferative neoplasms
7
Q
BRAF
A
- serine/threonine kinase
- melanoma, non Hodgkin, colorectal CA, papillary thyroid CA, hairy cell leukemia
8
Q
c-KIT
A
- cytokine receptor (CD117)
- GI stromal tumor (GIST), mastocytosis
9
Q
MYCC (c-myc)
A
- transcription factor
- Burkitt lymphoma
10
Q
MYCN (n-myc)
A
- transcription factor
- neuroblastoma
11
Q
KRAS
A
- RAS GTPase
- colorectal, lung, pancreatic CAs
12
Q
BCL2
A
- inhibits apoptosis
- follicular & diffuse large B cell lymphomas
13
Q
APC
A
- neg regulator B-cat/WNT path
- colorectal CA (associated w/ FAP)
14
Q
BRCA1/BRCA2
A
- breast, ovarian, prostate, pancreatic CAs
15
Q
CDKN2A
A
- p16, blocks G1 –> S phase
- many cancers
16
Q
DCC
A
- colorectal cancer
17
Q
SMAD4 (DPC4)
A
- pancreatic CA, colorectal CA
18
Q
MEN1
A
- menin protein
- MEN1
19
Q
NF1
A
- neurofibromin protein
- NF1
20
Q
NF2
A
- merlin (schwannomin) protein
- NF2
21
Q
PTEN
A
- neg regulator PI3k/AKT path
- prostate, breast & endometrial CAs
22
Q
RB1
A
- inhibits E2F / blocks G1 –> S phase
- retinoblastoma, osteosarcoma
23
Q
TP53
A
- p53, activates p21, blocks G1–> S phase
- most cancers
24
Q
TSC1
A
- Hamartin protein
- tuberous sclerosis
25
TSC2
- tuberin protein
- tuberous sclerosis
26
VHL
- inhibits hypoxia inducible factor 1a
- von Hippel Lindau disease
27
WT1
- urogenital development TF
- Wilms Tumor (nephroblastoma)
