Oncogen

Question 1

Front

Answer 1

Back

Question 2

Gene: ALK

Answer 2

Gene Product: Receptor tyrosine kinase
Associated Neoplasm: Lung adenocarcinoma

Question 3

Gene: EGFR (ERBB1)

Answer 3

Gene Product: Receptor tyrosine kinase
Associated Neoplasm: Lung adenocarcinoma

Question 4

Gene: HER2 (ERBB2)

Answer 4

Gene Product: Receptor tyrosine kinase
Associated Neoplasm: Breast and gastric carcinomas

Question 5

Gene: RET

Answer 5

Gene Product: Receptor tyrosine kinase
Associated Neoplasm: MEN2A and 2B, medullary and papillary thyroid carcinoma, pheochromocytoma

Question 6

Gene: BCR-ABL

Answer 6

Gene Product: Non-receptor tyrosine kinase
Associated Neoplasm: CML, ALL

Question 7

Gene: JAK2

Answer 7

Gene Product: Non-receptor tyrosine kinase
Associated Neoplasm: Myeloproliferative neoplasms

Question 8

Gene: BRAF

Answer 8

Gene Product: Serine/threonine kinase
Associated Neoplasm: Melanoma, non-Hodgkin lymphoma, colorectal carcinoma, papillary thyroid carcinoma, hairy cell leukemia

Question 9

Gene: c-KIT

Answer 9

Gene Product: Cytokine receptor (CD117)
Associated Neoplasm: Gastrointestinal stromal tumor (GIST), mastocytosis

Question 10

Gene: MYCC (c-myc)

Answer 10

Gene Product: Transcription factor
Associated Neoplasm: Burkitt lymphoma

Question 11

Gene: MYCN (N-myc)

Answer 11

Gene Product: Transcription factor
Associated Neoplasm: Neuroblastoma

Question 12

Gene: KRAS

Answer 12

Gene Product: RAS GTPase
Associated Neoplasm: Pancreatic, colorectal, lung, endometrial cancers

Question 13

Gene: BCL-2

Answer 13

Gene Product: Antiapoptotic molecule (inhibits apoptosis)
Associated Neoplasm: Follicular and diffuse large B-Cell lymphomas

Question 14

Gene: APC

Answer 14

Gene Product: Negative regulator of β-catenin/WNT pathway
Associated Condition: Colorectal cancer (associated with FAP)

Question 15

Gene: BRCA1/BRCA2

Answer 15

Gene Product: BRCA1/BRCA2 proteins
Associated Condition: Breast, ovarian, prostate, pancreatic cancers

Question 16

Gene: CDKN2A

Answer 16

Gene Product: p16, blocks G₁ → S phase
Associated Condition: Many cancers (e.g., melanoma, lung, pancreatic)

Question 17

Gene: DCC

Answer 17

Gene Product: Deleted in Colorectal Cancer
Associated Condition: Colorectal cancer

Question 18

Gene: SMAD4 (DPC4)

Answer 18

Gene Product: Deleted in Pancreatic Cancer
Associated Condition: Pancreatic cancer, colorectal cancer

Question 19

Gene: MEN1

Answer 19

Gene Product: Menin
Associated Condition: Multiple Endocrine Neoplasia type 1

Question 20

Gene: NF1

Answer 20

Gene Product: Neurofibromin (Ras GTPase activating protein)
Associated Condition: Neurofibromatosis type 1

Question 21

Gene: NF2

Answer 21

Gene Product: Merlin (schwannomin) protein
Associated Condition: Neurofibromatosis type 2

Question 22

Gene: PTEN

Answer 22

Gene Product: Negative regulator of PI3k/AKT pathway
Associated Condition: Prostate, breast, and endometrial cancers

Question 23

Gene: RB1

Answer 23

Gene Product: Inhibits E2F; blocks G₁ → S phase
Associated Condition: Retinoblastoma, osteosarcoma (bone cancer)

Question 24

Gene: TP53

Answer 24

Gene Product: p53, activates p21, blocks G₁ → S phase
Associated Condition: Most cancers, Li-Fraumeni (SBLA) syndrome (multiple malignancies at early age; Sarcoma, Breast/Brain, Lung/Leukemia, Adrenal gland)

Question 25

Gene: TSC1

Answer 25

Gene Product: Hamartin protein Associated Condition: Tuberous sclerosis complex

Question 26

Gene: TSC2

Answer 26

Gene Product: Tuberin (Zberin) Associated Condition: Tuberous sclerosis complex

Question 27

Gene: VHL

Answer 27

Gene Product: Inhibits hypoxia-inducible factor 1a Associated Condition: von Hippel-Lindau disease

Question 28

Gene: WT1

Answer 28

Gene Product: Urogenital development transcription factor Associated Condition: Wilms tumor (nephroblastoma)