Oncogenes Flashcards Preview

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Flashcards in Oncogenes Deck (12):
1

ALK gene product + associated neoplasm

Receptor tyrosine kinase
Lung adenocarcinoma

2

HER2/neu (c-erbB2) gene product + associated neoplasm

Receptor tyrosine kinase
Breast and gastric carcinoma

3

RET gene product + associated neoplasm

Receptor tyrosine kinase
MEN 2A and 2B, medullary thyroid cancer

4

BCR-ABL gene product + associated neoplasm

Tyrosine kinase
CML, ALL

5

JAK2 gene product + associated neoplasm

Non receptor tyrosine kinase - STAT activation
Chronic myeloproliferative disorders

6

cMYC gene product + associated neoplasm

Transcription factor
Burkitt Lymphoma

7

MYCL1 gene product + associated neoplasm

Transcription factor
Lung cancer

8

MYCN gene product + associated neoplasm

Transcription factor
Neuroblastoma

9

BCL-2 gene product + associated neoplasm

Antiapoptotic molecule
Follicular and diffuse large B cell lymphoma

10

BRAF gene product + associated neoplasm

Serine/threonine kinase
Melanoma, non Hodgkin lymphoma, papillary thyroid carcinoma

11

cKIT gene product + associated neoplasm

Cytokine receptor
Gastrointestinal Stromal Tumour (GIST)

12

KRAS gene product + associated neoplasm

GTPase
Pancreatic, colon and lung cancer