Paraneoplastic syndromes Flashcards Preview

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Flashcards in Paraneoplastic syndromes Deck (18):
1

Acanthosis nigricans

Hyperpigmented velvet plaques in axilla and neck
Gastric adenocarcinoma, other visceral malignancies

2

Sign of Leser Trelat

Sudden onset of multiple seborrheic keratoses
GI adenocarcinoma, other visceral malignancies

3

Hypercalcemia

Due to PTHrP - squamous cell carcinoma of lung, head and neck; renal, bladder, breast and ovarian carcinomas

Due to ↑ Vit D - lymphoma

4

Cushings syndrome

↑ ACTH → Small cell lung cancer

5

Hyponatremia - SIADH

↑ ADH → Small cell lung cancer

6

Polycythemia

↑ EPO → RCC, HCC, pheochromocytoma, hemangioblastoma, leiomyoma

7

Pure red cell aplasia

Anemia w/ no reticulocytes → Thymoma

8

Good syndrome

Hypogammaglobulinemia → Thymoma

9

Trosseau syndrome

Migratory superficial thrombophlebitis → adenocarcinomas, esp pancreatic

10

Marantic (non bacterial) endocarditis

Sterile platelet thrombi on heart valves → adenocarcinomas, esp pancreatic

11

Anti-NMDA receptor encephalitis

Psych disturbance, memory deficits, seizures, dyskinesias, autonomic instability, language dysfunction → ovarian teratomas

12

Opsoclonus-myoclonus ataxia syndrome

Dancing eyes and feet → neuroblastoma in kids, small cell lung cancer in adults

13

Paraneoplastic cerebellar degeneration

Abs against antigens in purkinje cells.
Anti-Hu → small cell lung cancer
Anti-Yo → breast and gyn cancers
Anti-Tr → Hodgkin lymphoma

14

Paraneoplastic encephalomyelitis

Abs against Hu antigens in neurons → small cell lung cancer

15

Lambert Eaton Myasthenic Syndrome

Abs against presynpatic Ca channels → small cell lung cancer

16

Myasthenia gravis

Abs against postsynaptic ACh receptors → thymoma

17

Thymoma

Pure red cell aplasia
Good syndrome
Mysathenia gravis

18

Small cell lung cancer

Paraneoplastic cerebellar degeneration
Paraneoplastic encephalomyelitis
Lambert Eaton Myasthenic Syndrome
Opsoclonus Myoclonus Ataxia syndrome
SIADH