Oncogenes and tumor suppressor genes

Question 1

BCR-ABL

Answer 1

GOF Tyrosine kinase: CML, ALL

Question 2

BCL-2

Answer 2

GOF Antiapoptotoic molecule: Follicular/undifferentiated lymphomas

Question 3

BRAF

Answer 3

GOF Serine/threonine kinase: Melanoma, nonHodgkin lymphoma

Question 4

c-kit

Answer 4

GOF Cytokine receptor: Gastrointestinal stromal tumor

Question 5

c-myc

Answer 5

GOF Transcription factor: Burkitt lymphoma

Question 6

HER2/neu

Answer 6

GOF Tyrosine kinase: Breast, ovarian, gastric carcinomas

Question 7

L-myc

Answer 7

GOF Transcription factor: lung tumor

Question 8

N-myc

Answer 8

GOF Transcription factor: Neuroblastoma

Question 9

RAS

Answer 9

GOF GTPase: Colon cacner, lung cancer, pancreatic cancer

Question 10

RET

Answer 10

GOF Tyrosine kinase: MEN2A, MEN2B, medullary thyroid cancer

Question 11

APC

Answer 11

Colorectal cancer associated with FAP (LOF)

Question 12

BRCA1/BRCA2

Answer 12

Breast and ovarian: LOF DNA repair protein gene

Question 13

DCC

Answer 13

Colon cancer: LOF DCC gene (“Deleted in colon cancer”)

Question 14

DPC4/SMAD4

Answer 14

Pancreatic cancer LOF DPC gene (“Deleted in pancreatic cancer”)

Question 15

MEN1

Answer 15

MEN1: LOF Menin gene

Question 16

NF1

Answer 16

NF1: LOF RAS GTPase activating protein (neurofibromin)

Question 17

NF2

Answer 17

NF2: LOF merlin (schwannomin protein)

Question 18

p16

Answer 18

Melanoma: LOF cyclin-dependent kinase inhibitor 2A

Question 19

p53

Answer 19

Most human cancers/Li-Fraumeni: LOF Transcription factor for p21, blocks G1–>S phase

Question 20

PTEN

Answer 20

Breast, prostate, endometrial cancer

PTEN~Prostate, tits, endometrial

Question 21

Rb

Answer 21

Osteosarcoma, Retinoblastoma: LOF inhibitor E2F, blocks G1->S phase

Question 22

TSC1

Answer 22

Tuberous sclerosis: LOF Hamartin protein

Question 23

TSC2

Answer 23

Tuberous sclerosis: LOF Tuberin protein

Question 24

VHL

Answer 24

von Hippel-Lindau/renal cell carcinoma: LOF inhibitor of hypoxia inducible factor 1a

Question 25

WT1/WT2

Answer 25

Wilms Tumor "nephroblastoma"