ONCOGENESIS SHIFTING Flashcards
(15 cards)
Which of the following activates the cyclin/cdk complex: A.VEGF B.cAMP C.contact inhibition D.p21
A
Which is TRUE statement about the G1/S cell cycle checkpoint?
A.It is regulated by Cyclin B/cdk 1
B.Mechanism involves phosphorylation of pRB
C.It is regulated mainly by intracellular signals
D.All of the above
E.None of the above
C
Which is TRUE of the Knudson’s Two-Hit Hypothesis?
A.It is applicable in both oncogenes and tumor suppressor genes
B.It states that any of the two hits mutations is enough to cause the phenotypic abnormality
C.The second hit involves a gross chromosomal loss
D.It is the principle of a dominant mutation
C
Phosphorylation of pRB results to: A.inactivation of E2F transcription factor B.cell cycle arrest C.activation of cyclin/cdk complex D.All of the above
B
Which is TRUE of dominant mutation in oncogenes?
A.It is a mutation resulting from conversion of proto-oncogene to oncogene
B.A mutation in a single allele is not enough to cause phenotypic abnormality
C.It is a mutation involving a gain in function of the mutator genes
D.The proto-oncogene loses its function
A
When pRB is inhibited, which of the following is/are true? A.pRB is in the phosphorylated state B.It results to cell cycle arrest C.It causes transcriptional repression. D.A and B are true E.B and C are true
A
Provides the pivotal decisional checkpoint in the fate of the cell after a death stimulus: A.Caspases B.cytochrome C C.BCL-2 death ligand
C
Apoptotic pathway important after chemotherapy and radiation: A.FAS-mediated B.TNF-mediated C.p53-mediated D.all of the above
C
The activity of this cyclin complex results to some condensation: A.cyclin B/cdk2 B.cyclin B/cdk1 C.cyclin D/cdk1 D.cyclin D/cdk2
B
Which is NOT true about oncogenes
A.They are mutated forms of protooncogenes
B.They are overexpressed in oncogenesis
C.APC in Familial Adenomatous polyposis is an example of oncogene
D.Mutation involving oncogenes are usually dominant
C
TRUE about oncogene activation in chronic myelogenous leukemia:
A.It involves gene translocation of chromosomes 9 and 14
B.The mutation results to fusion of BCR-ABL gene
C.It is a recessive type of mutation
It results to over-expression of c-myc
B
Human T-Cell Leukemia Virus HTLV-1
A.A is a DNA virus
B.forms an episome upon viral entry promoting cell latency
C.contains a TAX gene which activates transcription of genes encoding for lL-2
All are true
C
Viral oncoprotein which facilitates degradation of p53 A.EIA B.E6 C.E7 D.LMP-1
B
The single most common genetic change in human neoplasia involves. A.p21 B.p53 C.pRb bcl-2
B
Viral oncoprotein which inhibits pRB: A.LMP-1 B.E6 C.E7 D.EIA
C
