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Pathology - Neoplasia > Oncogenic microbes and carcinogens > Flashcards

Oncogenic microbes and carcinogens Flashcards

1
Q

EBV

A

Burkitt lymphoma, Hodgkin lymphoma,
nasopharyngeal carcinoma, 1° CNS
lymphoma (in immunocompromised patients)

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2
Q

HBV, HCV

A

HCC

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3
Q

HHV-8

A

Kaposi sarcoma

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4
Q

HPV

A

Cervical, penile, anal carcinoma (types 16, 18). Head and neck cancer

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5
Q

H. pylori

A

Gastric adenocarcinoma and MALT lymphoma

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6
Q

HTLV-1

A

Adult T cell leukemia/lymphoma

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7
Q

Clonorchis sinensis (liver fluke)

A

Cholangiocarcinoma

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8
Q

Schistosoma haematobium

A

Bladder cancer, squamous cell

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9
Q

What is known to produce aflatoxins?

A

aspergillus - can contaminate stored rice and grains

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10
Q

Organ toxicity of aflatoxins?

A

Liver

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11
Q

Cancer impact of aflatoxins?

A

Hepatocellular carcinoma

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12
Q

Organ toxicity of alkylating agents?

A

Blood

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13
Q

Cancer impact of alkylating agents?

A

Leukemia/lymphoma

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14
Q

Organ toxicity of aromatic amines (eg benzidine, 2-napthylamine)?

A

Bladder

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15
Q

Cancer impact of aromatic amines (eg benzidine, 2-napthylamine)?

A

Transitional cell carcinoma

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16
Q

Source of aromatic amines?

A

Cigarette smoke

17
Q

Organ toxicity of arsenic?

A

Liver, Lung, Skin

18
Q

Cancer impact of arsenic?

A

Angiosarcoma of liver
Lung Cancer
Squamous cell carcinoma of skin

19
Q

Source of arsenic?

A

Cigarette smoke

20
Q

Organ toxicity of asbestos?

A

Lung

21
Q

Cancer impact of asbestos?

A

Bronchogenic carcinoma>mesothelioma

22
Q

Organ toxicity of carbon tetrachloride?

A

Liver

23
Q

Cancer impact of carbon tetrachloride?

A

Centrilobular necrosis, fatty change

24
Q

Organ toxicity of cigarette smoke?

A 
Esophagus
Larynx
Lung
Pancreas
Kidney
Bladder
Cervix
25
Q

Cancer impact of cigarette smoke?

A 
Esophagus - SCC/adeno
Larynx - SCC
Lung - Sq, small cell
Pancreas - adenocarcinoma
Kidney - renal cell ca
Bladder - transitional 
Cervix - carcinoma
26
Q

Organ tox of ethanol?

A

Esophagus, Liver

27
Q

Cancer impact of ethanol?

A

SCC of eso/oropharynx

HCC of liver

28
Q

Organ tox of ionizing radiation?

A

Thyroid

29
Q

Cancer impact of ionizing radiation?

A

Papillary thyroid carcinoma

30
Q

Source of Nitrosamines?

A

Smoked foods (japan!)

31
Q

Organ toxicity of nitrosamines?

A

Stomach

32
Q

Cancer impact of nitrosamines?

A

gastric cancer

33
Q

Organ impact of Radon?

A

Lung

34
Q

Cancer impact of Radon?

A

Lung Ca - 2nd leading cause after smoking

35
Q

Vinyl chloride source?

A

Occupational exposure - used to make PVC pipes

36
Q

Organ tox of vinyl chloride?

A

Liver

37
Q

Cancer impact of vinyl chloride?

A

Angiosarcoma

38
Q

Nickel/chromium, beryllium, or silicia

A

Lung carcinoma

Pathology - Neoplasia (8 decks)

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