Oncogenic microbes and carcinogens

Question 1

EBV

Answer 1

Burkitt lymphoma, Hodgkin lymphoma,
nasopharyngeal carcinoma, 1° CNS
lymphoma (in immunocompromised patients)

Question 2

HBV, HCV

Answer 2

HCC

Question 3

HHV-8

Answer 3

Kaposi sarcoma

Question 4

HPV

Answer 4

Cervical, penile, anal carcinoma (types 16, 18). Head and neck cancer

Question 5

H. pylori

Answer 5

Gastric adenocarcinoma and MALT lymphoma

Question 6

HTLV-1

Answer 6

Adult T cell leukemia/lymphoma

Question 7

Clonorchis sinensis (liver fluke)

Answer 7

Cholangiocarcinoma

Question 8

Schistosoma haematobium

Answer 8

Bladder cancer, squamous cell

Question 9

What is known to produce aflatoxins?

Answer 9

aspergillus - can contaminate stored rice and grains

Question 10

Organ toxicity of aflatoxins?

Answer 10

Liver

Question 11

Cancer impact of aflatoxins?

Answer 11

Hepatocellular carcinoma

Question 12

Organ toxicity of alkylating agents?

Answer 12

Blood

Question 13

Cancer impact of alkylating agents?

Answer 13

Leukemia/lymphoma

Question 14

Organ toxicity of aromatic amines (eg benzidine, 2-napthylamine)?

Answer 14

Bladder

Question 15

Cancer impact of aromatic amines (eg benzidine, 2-napthylamine)?

Answer 15

Transitional cell carcinoma

Question 16

Source of aromatic amines?

Answer 16

Cigarette smoke

Question 17

Organ toxicity of arsenic?

Answer 17

Liver, Lung, Skin

Question 18

Cancer impact of arsenic?

Answer 18

Angiosarcoma of liver
Lung Cancer
Squamous cell carcinoma of skin

Question 19

Source of arsenic?

Answer 19

Cigarette smoke

Question 20

Organ toxicity of asbestos?

Answer 20

Lung

Question 21

Cancer impact of asbestos?

Answer 21

Bronchogenic carcinoma>mesothelioma

Question 22

Organ toxicity of carbon tetrachloride?

Answer 22

Liver

Question 23

Cancer impact of carbon tetrachloride?

Answer 23

Centrilobular necrosis, fatty change

Question 24

Organ toxicity of cigarette smoke?

Answer 24

Esophagus
Larynx
Lung
Pancreas
Kidney
Bladder
Cervix

Question 25

Cancer impact of cigarette smoke?

Answer 25

``` Esophagus - SCC/adeno Larynx - SCC Lung - Sq, small cell Pancreas - adenocarcinoma Kidney - renal cell ca Bladder - transitional Cervix - carcinoma ```

Question 26

Organ tox of ethanol?

Answer 26

Esophagus, Liver

Question 27

Cancer impact of ethanol?

Answer 27

SCC of eso/oropharynx | HCC of liver

Question 28

Organ tox of ionizing radiation?

Answer 28

Thyroid

Question 29

Cancer impact of ionizing radiation?

Answer 29

Papillary thyroid carcinoma

Question 30

Source of Nitrosamines?

Answer 30

Smoked foods (japan!)

Question 31

Organ toxicity of nitrosamines?

Answer 31

Stomach

Question 32

Cancer impact of nitrosamines?

Answer 32

gastric cancer

Question 33

Organ impact of Radon?

Answer 33

Lung

Question 34

Cancer impact of Radon?

Answer 34

Lung Ca - 2nd leading cause after smoking

Question 35

Vinyl chloride source?

Answer 35

Occupational exposure - used to make PVC pipes

Question 36

Organ tox of vinyl chloride?

Answer 36

Liver

Question 37

Cancer impact of vinyl chloride?

Answer 37

Angiosarcoma

Question 38

Nickel/chromium, beryllium, or silicia

Answer 38

Lung carcinoma