Tumor markers Flashcards

1
Q

Alkaline phosphatase

A

Metastases to bone or liver, Paget disease of

bone, seminoma (placental ALP).

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2
Q

alpha-fetoprotein

A

Hepatocellular carcinoma, hepatoblastoma, yolk
sac (endodermal sinus) tumor, mixed germ
cell tumor.
(normally made my fetus)

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3
Q

What are high levels of AFP associated with in pregnancy?

A

Neural tube and abdominal wall defects

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4
Q

What are low levels of AFP associated with in pregnancy?

A

Down syndrome

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5
Q

CA15-3/CA27-29

A

Breast cancer

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6
Q

CA-19-9

A

Pancreatic adenocarcinoma

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7
Q

CA 125

A

Ovarian cancer

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8
Q

Calcitonin

A

Medullary thyroid carcinoma

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9
Q

CEA

A

CarcinoEmbryonic Antigen. Very nonspecific but produced by ∼ 70% of colorectal and
pancreatic cancers; also produced by gastric,
breast, and medullary thyroid carcinomas.

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10
Q

Chromogranin

A

Neuroendocrine tumors/carcinoid

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11
Q

PSA

A

prostate specific antigen, prostate cancer. Also elevated in BPH/prostatitis.

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12
Q

bHG

A

choriocarcinoma

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13
Q

LDH, hCG

A

dysgerminoma

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