Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Year 6 Medicine > Oncology > Flashcards

Oncology Flashcards

1
Q

MOA cyclophosphamide?

A

alkylating agent

causes cross linked in DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

SE cyclophosphamide?

A

haemorrhagic cystitis
myelosuppression
transitional cell carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Bleomycin MOA?

A

Cytotoxic antibody

degrades preformed DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

SE bleomycin?

A

lung fibrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

MOA anthracyclines e.g. doxorubicin?

A

cytotoxic antibodies
stabilises DNA topoisomerase II complex
inhibits DNA and RNA synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Methotrexate MOA?

A

Antimetabolite

inhibits dihydrofolate reductase and thymidylate synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

SE methotrexate?

A

myelosuppression
mucositis
liver fibrosis
lung fibrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

MOA 5-FU?

A

antimetabolite

pyrimidine analogue inducing cell cycle arrest and apoptosis by blocking thymidylate synthase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

SE 5-FU?

A

myelosuppression
mucositis
dermatitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

MOA 6MP?

A

antimetabolite

purine analogue that is activated by HGPRTase, decreasing purine synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

SE 6MP?

A

myelosuppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

MOA cytarabine?

A

pyrimidine antagonist
antimetabolite
interferes with DNA synthesis specifically at the S phase of the cell cycle and inhibits DNA polymerase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

SE cytarabine?

A

myelosuppression

ataxia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

MOA vincristine/vinblastine?

A

anti-microtubule

inhibits formation of microtubules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

SE vincristine/vinblastine?

A

vincristine: peripheral neuropathy (reversible), paralytic plus
vinblastine: myelosuppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

MOA docetaxel?

A

anti-microtubule
prevents microtubule depolymerisation and disassembly
decreasing free tubular

17
Q

SE docetaxel?

A

neutropenia

18
Q

MOA irinotecan?

A

topoisomerase inhibitors

inhibits topoisomerase I, prevents relaxation of supercoiled DNA

19
Q

SE irinotecan

A

myelosuppresion

20
Q

Cisplatin MOA?

A

causes cross linking in DNA

21
Q

SE cisplatin?

A

ototoxicity, peripheral neuroapathy, hypomagnesaemia

22
Q

MOA hydroxyurea (hydroxycarbamide)

A

inhibits ribonucleotide reductase

less DNA synthesis

23
Q

SE hydroxyurea?

A

myelosuppression

Year 6 Medicine (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions