Oncology

Question 1

G1 presynthetic phase

Answer 1

Etoposide

Question 2

S - DNA synthesis

Answer 2

Antimetabolites

Question 3

G2 Premitotic phase

Answer 3

Bleomycin

Question 4

M - Mitosis

Answer 4

Antimitotic

Question 5

Platinum

Answer 5

Cisplatin
Carboplatin
Oxaliplatin

Question 6

WOF when taking Platinum

Answer 6

Nephrotoxic, ototoxic
WTD? Hydration

Question 7

Nitrogen mustard

Answer 7

Mechlorethamine

Question 8

Busulfan (WOF)

Answer 8

Pulmonary fibrosis

Question 9

Cyclophosphamide (WOF)

Answer 9

Toxic metabolite: Acrolein
-hemorrhagic, steril, cystisis

Question 10

WTD? (WOF) of Acrolein

Answer 10

Mercaptoethane
Sulfonate sodium
“MESNa”

Question 11

Antitumor antibiotic

Answer 11

Mitomycin
Bleomycin

Question 12

Antitumor antibiotic (WOF)

Answer 12

Vessicant
Pulmonary fibrosis

Question 13

Anthracycline

Answer 13

Doxorubicin

Question 14

Doxorubicin (MOA & WOF)

Answer 14

(-) topoisomerase II = Cardiotoxicity

WTD? Dexrazoxane

Question 15

Podophyllotoxin

Answer 15

Etoposide G1

Question 16

Etoposide G1 (MOA & WOF)

Answer 16

(-) topoisomerase II

Bone marrow toxicity

Question 17

Camptothecin

Answer 17

Irinotecan
Topotecan

Question 18

Campthothecin (MOA & WOF)

Answer 18

(-) topoisomerase I

BMT
Diarrhea

Question 19

Methotrexate: MOA

Answer 19

(-) dihydrofolate reductase

Question 20

Methotrexate: Uses

Answer 20

1st line DMARDs vs RA
for ectopic pregnancy

Question 21

Methotrexate: WOF

Answer 21

-BM Toxicity
-Hepatotoxicity

WTD? Leucovorin/Folinic acid

Question 22

Pemetrexed: MOA

Answer 22

(-) thymidylate synthase

Question 23

Pemetrexed: WOF

Answer 23

Hand and Foot syndrome

Question 25

Pemetrexed: WTD for toxicity?

Answer 25

Dexamethasone

Question 26

Pyrimidine analogues

Answer 26

Capecitabine, Cytarabine, 5-flourouracil = colon cancer

Question 27

Purie analogues

Answer 27

Mercaptopurine

Question 28

Taxane or Vinca Alkaloids? Effect: Assembly

Answer 28

Taxanes

Question 29

Taxane or Vinca Alkaloids? Effect: Disassembly

Answer 29

Vinca alkaloids

Question 30

Taxane or Vinca Alkaloids? Tavus brevifolia

Answer 30

Taxanes

Question 31

Taxane or Vinca Alkaloids? Catharantus roseus "Periwinkle"

Answer 31

Vinca alkaloids

Question 32

Taxane or Vinca Alkaloids? Paclitaxel Docetaxel

Answer 32

Taxane

Question 33

Taxane or Vinca Alkaloids? Vincristine and Vinblastine

Answer 33

Vinca alkaloids

Question 34

Taxanes WOF

Answer 34

Allergy

Question 35

Vincristine WOF

Answer 35

Neurotoxic

Question 36

Vinblastine WOF

Answer 36

Bone marrow toxicity

Question 37

Interleukine-2 is used for

Answer 37

Renal cell cancer

Question 38

Examples of Cytokine & Cytokine modifiers

Answer 38

Thalidomide (more toxic) & Lenalidomide vs. multiple myeloma

Question 39

Monoclonal AB or Tyrosine kinase inhibitor -mab

Answer 39

Monoclonal AB

Question 40

Monoclonal AB or Tyrosine kinase inhibitor with extracellular target

Answer 40

Monoclonal AB

Question 41

Monoclonal AB or Tyrosine kinase inhibitor AntiCD20 = drug

Answer 41

Monoclonal AB Rituximab

Question 42

Monoclonal AB or Tyrosine kinase inhibitor anti EGFR = drug

Answer 42

Monoclonal AB Trastuzumab

Question 43

Monoclonal AB or Tyrosine kinase inhibitor anti-VEGF drug

Answer 43

Monoclonal AB Bevacizumab

Question 44

Monoclonal AB or Tyrosine kinase inhibitor -inib

Answer 44

Tyrosine kinase inhibitor

Question 45

Monoclonal AB or Tyrosine kinase inhibitor with intracellular target

Answer 45

Tyrosine kinase inhibitor

Question 46

Monoclonal AB or Tyrosine kinase inhibitor vs. c-KIT (+) tumors

Answer 46

Tyrosine kinase inhibitor Imatinib

Question 47

Monoclonal AB or Tyrosine kinase inhibitor vs. lung cancer

Answer 47

Tyrosine kinase inhibitor Eriotinib