oncology Flashcards
(22 cards)
chemo working at G1 phase of cell cycle
pegaspargase
chemo working at S phase of cell cycle
DNA replication
antimetabolites: methotrexate, fluorouracil
topoisomerase II inhibitors: irinotecan, topotecan
chemo working at G2 phase of cell cycle
etoposide, bleomycin
chemo working at M phase of cell cycle
taxanes: paclitaxel, docetaxel
vinca alkaloids: vincristine, vinblastine
cell cycle nonspecific chemo: tumor killing is not dependent on the phase of the cell cycle
Alkylating agents: cyclophosphamide, ifosfamide
Anthracyclines: doxorubicin, daunorubicin
Platinum compounds: cisplatin, oxaliplatin, carboplatin
which chemo causes neurotoxicity
carmustine
which chemo causes ototoxicity, nephrotoxicity, and high emetogenicity
cisplatin
which chemo causes mucositis
methotrexate, fluorouracil, capecitabine
which chemo causes pulmonary toxicity
bleomycin, busulfan, carmustine
which chemo causes cardiotoxicity
anthracyclines (doxorubicin)
which chemo causes hemorrhagic cystitis
ifosfamide, high dose cyclophosphamide
which chemo causes diarrhea
irinotecan
which chemo causes peripheral neuropathy
platinum based compounds, vinca alkaloids, taxanes
which chemo causes bone marrow suppression
most chemotherapy except bleomycin, vincristine, and pegaspargase
how to prevent nephrotoxicity with cisplatin
amifostine, limit dose per cycle to <100 mg/m2
how to prevent mucositis with methotrexate
leucovorin
how to prevent pulmonary toxicity with bleomycin
limit lifetime cumulative dose to 400 units
how to prevent cardiotoxicity with doxorubicin
dexrazoxane, limit lifetime cumulative dose to 450-550 mg/m2
how to prevent hemorrhagic cystitis with cyclophosphamide and ifosfamide
mesna
how to prevent diarrhea with irinotecan
atropine
how to prevent peripheral neuropathy with oxaliplatin
avoid cold exposure
how to prevent peripheral neuropathy with vincristine
limit single doses to 2 mg
