Oncology

Question 1

BCR-ABL

Answer 1

oncogene
CML, ALL
tyrosine kinase, Philadelphia chromosome

Question 2

bcl-2

Answer 2

oncogene
follicular and undifferentiated lymphomas
anti-apoptotic molecule

Question 3

BRAF

Answer 3

oncogene
melanoma
serine/threonine kinase

Question 4

c-kit

Answer 4

oncogene
gastrointestinal stromal tumor (GIST)
cytokine receptor (for stem cell factor)

Question 5

c-myc

Answer 5

oncogene
Burkitt lymphoma
transcription factor

Question 6

HER2/neu (c-erbB2)

Answer 6

oncogene
breast, ovarian, gastric carcinoma
tyrosine kinase

Question 7

L-myc

Answer 7

oncogene
lung tumor
transcription factor

Question 8

N-myc

Answer 8

oncogene
neuroblastoma
transcription factor

Question 9

ras

Answer 9

oncogene
colon cancer, lung cancer, pancreatic cancer
GTPase

Question 10

ret

Answer 10

oncogene
MEN 2A and 2B
tyrosine kinase

Question 11

APC

Answer 11

tumor suppressor

colorectal cancer

Question 12

BRCA1

Answer 12

tumor suppressor
breast and ovarian cancer
DNA repair protein

Question 13

BRCA-2

Answer 13

tumor suppressor
breast and ovarian cancer
DNA repair protein

Question 14

CPD4/SMAD4

Answer 14

tumor suppressor
pancreatic cancer
DPC

Question 15

DCC

Answer 15

tumor suppressor
colon cancer
DCC

Question 16

MEN1

Answer 16

tumor suppressor

MEN type 1

Question 17

NF1

Answer 17

tumor suppressor
neurofibromatosis type 1
RAS GTPase activating protein (neurofibromin)

Question 18

NF2

Answer 18

tumor suppressor
neurofibromatosis type 2
Merlin (schwannomin) protein

Question 19

p16

Answer 19

tumor suppressor
melanoma
cyclin-dependent kinase inhibitor 2A

Question 20

p53

Answer 20

tumor suppressor
most human cancers, Li-Fraumeni syndrome
transcription factor for p21, blocks G1–> S phase

Question 21

PTEN

Answer 21

tumor suppressor

breast cancer, prostate cancer, endometrial cancer

Question 22

Rb

Answer 22

tumor suppressor
retinoblastoma, osteosarcoma
inhibits E2F; blocks G1–> S phase

Question 23

TSC1

Answer 23

tumor suppressor
tuberous sclerosis
hamartin protein

Question 24

TSC2

Answer 24

tumor suppressor
tuberous sclerosis
tuberin protein

Question 25

VHL

Answer 25

tumor suppressor von Hippel-Lindau disease inhibits hypoxia inducible factor 1a

Question 26

WT1

Answer 26

``` tumor suppressor Wilms Tumor (nephroblastoma) ```

Question 27

WT2

Answer 27

``` tumor suppressor Wilms tumor (nephroblastoma) ```

Question 28

t(9;22)

Answer 28

Philadelphia chromosome CML bcr-abl hybrid

Question 29

t(8;14)

Answer 29

Burkitt lymphoma | c-myc activation

Question 30

t(11;14)

Answer 30

Mantle cell lymphoma | cyclin D1 activation

Question 31

t(14;18)

Answer 31

Follicular lymphomas | bcl-2 activation

Question 32

t(15;17)

Answer 32

M3 type of AML | responsive to all-trans retinoic acid