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Paeds Exam Cram > Oncology > Flashcards

Oncology Flashcards

(92 cards)

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1
Q

t(1:19)

A

pre B ALL

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2
Q

t(8:14)

A

C-MYC - Burkitts

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3
Q

t(15:17)

A

Acute promyelocytic leukaemia

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4
Q

t(9:22)

A

Philadelphia - ALL, CML (POOR prognosis)

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5
Q

t(11:22)

A

Ewing’s

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6
Q

t(12:21)

A

ALL (GOOD prognosis)

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7
Q

t(11q:22)

A

Wilms

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8
Q

N MYC

A

Neuroblastoma (poor prognosis)

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9
Q

EGFR

A

Glioblastoma

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10
Q

1p

A

AML

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11
Q

10q (RET)

A

MEN2

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12
Q

INI1 deltion

A

Atypical teratoid rhabdoid tumour (ATRT)

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13
Q

15q mutation

A

Blood

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14
Q

p53 mutation

A

Soft tissue sarcoma/Li Fraumeni

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15
Q

11p deletion (WT1)

A

Wilms/WAGR

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16
Q

13q deletion (RB1)

A

Retinoblastoma

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17
Q

GATA1

A

AML in T21

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18
Q

RB2 Retinoblastoma

A

(2 hit Chr13) Osteosarcoma

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19
Q

p53 Li Fraumeni Syndrome

A

Bone, soft tissue, breast

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20
Q

NF1 Neurofibromatosis 1

A

Optic glioma, brain glioma, meningioma, neurofibroma, phaechromocytoma, sarcoma

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21
Q

NF2 Neurofibromatosis 2

A

Bilateral acoustic neuroma

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22
Q

WT1 Wilms, WAGR

A

Wilms, aniridia (no irs), genitourinary abnormalities, mental retardation)

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23
Q

Von Hippel Lindau

A

Renal cell carcinoma, phaeochromocytoma, pancreatic tumour

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24
Q

PTEN

A

Glioblastoma

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25
INI1
Atypical Teratoid Rhabdoid Tumour (ATRT)
26
APC
Hepatoblastoma
27
MEN1
Pancreas, pituitary, parathyroid tumours
28
MEN 2A + 2B - RET
Phaechromocytoma, parathyroid adenoma, medullary thyroid carcinoma
29
Trisomy 21
Transient leukamoid reaction in newborn 10% ALL increased risk 20% AML increased risk 400%
30
Klinfelter syndrome (47XXY)
Breast cancer
31
Noonan Syndrome
Juvenile myelomonocytic leukaemia
32
Beckwith Weiderman/hemi-hypertrophy
Wilm's tumour, hepatoblastoma
33
Fanconi anaemia
Leukaemia (especially AML)
34
Ataxia-telangectasia
Lymphoma, leukaemia
35
DiGeorge
Thymoma
36
Severe Combined Immunodeficiency
Leukaemia, lymphoma
37
Wiskott-Aldrich
Non-Hodgkin's Lymphoma, leukaemia
38
X Linked agammaglobulinaemia
Lymphoma, leukaemia
39
X Linked lymphoproliferative
Non-Hodgkin's Lymphoma
40
Ataxia telangiectasia
Non-Hodgkin's Lymphoma
41
Tuberous sclerosis
Myocardial rhabdomyoma, giant cell astrocytoma
42
MEN1 (multiple endocrine neoplasia syndrome)
Parathyroid, pancreatic islet, Pituitary
43
MEN2A
Thyroid, phaeochromocytoma
44
Familial Adenomatous Polyposis
Colorectal, thyroid, duodenal, hepatoblastoma
45
Haemochromatosis
Hepatocellular
46
BRCA1 BRCA2
Breast, ovarian
47
Diamond-Blackfan anaemia
AML, meylodysplastic syndrome
48
Schwachman Diamond
AML, myelodysplasia
49
Hodkins Lymphoma
Adolescence 4x risk post EBV Painless node, mediastinal mass, B symptoms, hepatosplenomegaly, Reed-Sternberg Chemo + RTX Highest risk secondaryy cancer (lung M+F, breast F)
50
Non-Hodgkins lymphoma
``` Age 10 More common, rapidly growing, better prognosis Horners* T cell - mediastinal mass B cell - abode distension High LDH poor prognosis Risk of tumour lysis Chemotherapy ```
51
Neuroblastoma
Infants <2yo Adrenal**, paraspinal (mets to bone, orbit, liver, skin) Presentation: sick, abdominal mass - crosses midline*, Horners*, Mets - Racoon eyes Paraneoplastic - opsoclonus myoclonus High urine catecholamines (HVA, MVA), ferritin, LFH Resection, chemo +/- RTX, autologous SCT Stage 4s - <1y hepatomegaly, disseminated, regresses
52
Wilms (nephroblastoma)
``` 2-3yo Well, abdominal mass doesn't cross midline Assoc BWS/HH, WAGR, Denys Drash Surgery Chemo +/- RTX ```
53
Retinoblastoma
Familial <1yo - Bilateral, worse Sporadic >1yo, unilateral White reflex, strabismus Mets to optic nerve, orbit Late risk: osteosarcoma
54
Langerhan Cell Histiocytosis
``` 5-10yo Birbeck cells Skin blueberry rash Skull- punched out holes Single system/multifocal/multisystem - wrose Chemo ```
55
HLH
Fever, lymph, hepatosplenomegaly, jaundice Ferritin high (prognostic >10000), sCD25, high triglycerides, haemophagocytosis film/marrow Dex, IVIG, chemo, BMT
56
Hepatoblastoma
<180mo RUQ mass, previous puberty High HCG/AFP Surgery/chemo/transplant Associated with BWS/HH, FAP, FAS
57
Germ cell tumour
3yo/adol Gonads RF: 47XXY, T21, 45XO, high AFP/HCG
58
Rhabdomyosarcoma
<6yo head/neck/orbit Assoc NF, LF, BWS Surgery/chemo/RTX
59
Medulloblastoma
Good - WNT, SHH | Bad - MYC +
60
Wilms
Bad - loss of 16q or 1p
61
Neuroblastoma
Good - hyperploid | Bad - nMYC amplification, 1p loss, 17q gain, diploid or triploid, high markers (LDH, ferritin)
62
ALL
Good - hyperploid, WCC <50, *response to treatment*, 1-10yo* Bad - WCC >50, hypoploidy, t(4,11), 11q23 Very Bad - t(9,22)*, *failure of induction*, t(8,14), Burkitt
63
AML
Good - low MRD at 2nd end point, t(15,17), APML very responsive to treatment Bad - MLL rearrangements, monosomy 7
64
Cysplatin
Severe nausea + vomiting SNHL Nephrotoxicity
65
Carboplatin
SNHL, nephrotoxicity
66
Bleomycin
Pulmonary fibrosis, mucositis
67
Bulsulphan
Pulmonary fibrosis, seizures
68
Doxyrubicin
Cardiotoxicity, myelosuppression, stomatitis, red pee
69
Cyclophosphamide
Haemorrhagic cystitis Infertility Secondary malignancy (AML)
70
Itopaside/Ifosfamide
Haemorrhagic cystitis Infertility Secondary malignancy (Fanconi, encephalopathy - ifosfamide)
71
Methotrexate
Myelosuppression Mucositis Liver/renal damage CI in pericarditis
72
6MP (mercaptopurine)
Myelosuppression | Hypoglycaemia
73
Vincristine
Jaw pain Peripheral neuropathy SIADH
74
Asparginase
Anaphylaxis Pancreatitis Coagulopathy DM
75
Etoposide
``` Myelosuppression Secondary malignancy (AML) ```
76
Actinomycin
VOD (Wilm's tumour)
77
Secondary malignancy
Cyclophosphamide | Itopaside/ifosfamide
78
Severe/delayed nausea
Cysplatin
79
Infertility
Cyclophosphamide
80
RTA/Fanconi anaemia
Ifosfamide
81
Jaw pain
Vincristine
82
Haematuria
Cyclophosphamide, ifosfamide
83
Encephalopathy
Ifosfamide
84
Cardiotoxity
Doxyrubicin
85
Red pee
Doxyrubicin
86
Shortness of breath
Bleomycin
87
Mucositis
Methotrexate (combination treatment -ubicin)
88
Myelosuppression
Dose dependent
89
Pancreatitis
Asparginase
90
Allergy/anaphylaxis
Aspariginase
91
Radiation recall/avoid in radiation
Doxyrubicin, actinomycin
92
Fungal infections
Prolonged neutropenia

Paeds Exam Cram (19 decks)

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