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Oncology > Oncology Letters and Numbers > Flashcards

Oncology Letters and Numbers Flashcards

1
Q

Chro 17q mutation

A

BRCA1: dsDNA repair

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2
Q

Chro 13q mutation

A

BRCA2: dsDNA repair

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3
Q

Chro 17 EGFR overexpression

A

HER2

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4
Q

E-Cadherin +

A

Invasive Ductal Carcinoma

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5
Q

E-Cadherin -

A

Lobar Carcinoma

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6
Q

p53 inactive, kras active, EGFR mutation (activates kras), EML4&ALK Chimera

A

Lung Cancer

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7
Q

AK53

A

colon cancer (inactivates APC)

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8
Q

APC

A

colon cancer (inactivates APC)

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9
Q

Wnt

A

colon cancer (how APC blocks growth)

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10
Q

MLH1 & 2

A

decreased in lynch

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11
Q

BRAF mutation

A

lynch

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12
Q

MiB1/Ki67+

A

adenomatous polyp (proliferation)

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13
Q

p16/CDKN2a

A

Pancreatic ductal adenocarcinoma (leads to TP53, SMAD)

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14
Q

TP53

A

pancreatic ductal adenocarcinoma

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15
Q

SMAD4

A

pancreatic ductal adenocarcinoma

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16
Q

hMLH1

A

pancreatic ductal adenocarcinoma (familial, 5%)

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17
Q

hSMH2

A

pancreatic ductal adenocarcinoma (familial, 5%)

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18
Q

CDH1/E-cadherin mutations

A

diffuse gastric cancer (AD inheritance)

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19
Q

E6

A

degrades p53 (HPV16,18)

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20
Q

E7

A

increases DNA synth (HPV16, 18)

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21
Q

16, 18, 6, 11

A

Gardasil HPV strains

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22
Q

MLH1, MSH2/6. PMS2, PTEN

A

uterine cancer (HNPCC/Lynch, p53 loss etc)

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23
Q

LDH

A

dysgerminoma (uterine germ cell)

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24
Q

hCG

A

choriocarcinoma (uterine germ cell)

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25
AFP
yolk sac tumor (uterine germ cell)
26
VHL mutation
clear cell renal carcinoma
27
HPRC (MET path) or HGLRCC
papillary renal cell carcinoma
28
HIF
almost all renal cell carcinoma
29
Chr 3p loss
clear cell renal carcinoma (VHL)
30
Chro 7 & 17 trisomy
papillary renal cell carcinoma (HPRC/HGLRCC)
31
loss of chro 1,6,19
chromophobe RCC (best prog)
32
LOF in Wt1 (11p13)
wilms tumor/nephroblastoma (from denys-drash or mutation)
33
increased APF and/or betaHCG +/- LDH
Non-seminomatous testicular cancer
34
increased betaHCG +/- LDH
seminomatous testicular cancer
35
Loss of GSTP1
PTEN/p53/Rb/Myc loss (testicular cancer
36
loss of p16
squamous cell carcinoma
37
p16 overexpression
HPV SCC (nonkeratinizing, better prog)
38
EWS-FLI1
ewings sarcoma, tx chemo
39
C-KIT mutation
GI stromal tumor, tx imatinib
40
T(8;21)(15;17), inv(16)
good AML prog
41
5q, chemo, complex karyotype
bad AML prog
42
T(15;17), PML/RARa fusion transcript
APL (AML M3)
43
Tdt+, Ig+, CD10+
B-cell ALL
44
Tdt+, CD2+, CD3+
T-cell ALL
45
T(9;22)
philly! Bad ALL (>60)
46
T(4;11)
bad ALL (<1)
47
del (5q31) leads to del (RPS14)
5q (MDS subtype)
48
JAK2V617F
polycythemia vera (92%)
49
JAK2 mut
essential thrombocytosis (42%)
50
CALR better prog than JAK2
primary myelofibrosis
51
MR3 (major) >3 log BCR-ABL reduction, MR4.5 (complete) >4.5
CML
52
T(9;22) BCR-ABL fusion
CML (increased TK activity)
53
CD20+***, CD5+
CLL
54
13q-
good CLL prog (-13q14 is intermediate MM)
55
11q-, 17p-
Bad CLL prog
56
CD19+, CD20+, CD10+, BC16+ (germinal center markers)
DLBCL
57
BCL6 overexpression
GC type DLBCL
58
NFkP addition
Non-GC DLBCL
59
CD30 mutation
Type 3 (primary mediastinal) BCL
60
IgM, CD19+, CD20+, CD10+, BC16+ (germinal center markers), NEVER Bcl12
burkitt's lymphoma
61
C-myc translocation from t(8;14), t (8;22) or t(2;8)
+EBV! Burkitt's lymphoma
62
CD5+, Cyclin D1+
mantle zone lymphoma
63
transloaction of cyclin D1 (11) and heavy-chain Ig (14)
mantle zone lymphoma
64
Ki67
levels=prog for mantle cell (blastic is worst, leukemic is best)
65
CD19+, CD20+, but no CD10
MALT (extra-nodal marginal zone lymphoma)
66
increased NfkB
MALT (extra-nodal marginal zone lymphoma)
67
ALK+
good prog in Anaplastic Large Cell lymphome
68
CD30+
Anaplastic Large Cell Lymphoma, tx: brentuximab
69
T(2;5) mutation
younger better Anaplastic Large Cell Lymphoma
70
Bc16, CD10, but NO CD2,3,5,7
Angioblastic T-Cell Lymphoma
71
Coombs- anemia, gamma/delta TCR rearrangement
hepatosplenic t-cell lymphoma
72
alpha/beta TCR rearrangement, CD3, CD8, NO NKs (CD56-)
subcutaneous panniculitis-like lymphoma
73
TAX+. CD4+, CD25+
Adult T-cell Lymphoma (HTLV1)
74
HTLV-1
virus, causes Adult T-cell lymphoma (Caribbean)
75
PAX+, CD15+, CD30+
hodgkins
76
CD20+, CD30(=)
+cervical LAD! Lymph-prominent Hodgkins
77
CD38+ (kappa/gamma restricted)
+Mott, Dutcher: MM
78
T(4;14)(p16;q32), t(14;16)(q32;q23), and -p53 (-17p13)
Bad MM prog
79
13q14 deletion
intermediate MM prog (13- is good CLL)

Oncology (5 decks)

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