ONDANSETRON Flashcards
1
Q
Class
A
Seratonin (5-HT3) antagonist
2
Q
Mechanism of Action
A
Highly selective competitive antagonsist of the serotonin receptor
Effect is central, possibly in the area postrema of the brainstem
3
Q
Dosing: adult prophylaxis, pediatric prophylaxis, treatment (adults)
A
Adult prophylasis: 4 mg IV prior to emergence
Pediatric prophylaxis: 50 - 150 ug / kg IV
Treatment (adults): 1-2 mg IV
4
Q
Onset
A
Less than 30 min
5
Q
Duration
A
9 hours
6
Q
Elimination
A
Hepatic
7
Q
CNS Effects
A
Headache
8
Q
CVS Effects
A
Prolongation of QT
9
Q
GI Effects
A
Constipation, elevation of liver enzymes
10
Q
Misc. Effects
A
Elimination is prolonges when other drugs are metabolized by cytochrome P450
