One Compartment Model Flashcards
(18 cards)
Zero order elimination rate
Constant K
Zero Order elimination rate constant units
Amount / time
Zero Order half life
Amount or conc / 2 x K
Clearance Zero Order
N/A
VD Zero Order
N/A
First Order elimination rate
K x amount or k x conc
First Order elimination rate constant units
1/ time
Half life First Order
0.693/K
First Order CL
V x k or dose/AUC
First Order VD
Dose IV / C
One compartment model
Same as first order
Mixed order km
Conc at 1/ 2 vmax
Vmax mixed order
Max velocity
Mixed order elimination rate
Vmax / km + C
Mixed order elimination rate
Vmax x km / CL
Half life mixed order
High conc: amount / 2 x k
Low conc: 0.693/k
CL mixed order
Vmax x km / C
Is mixed first or 0 order?
1st order at low amounts and 0 order at high amounts