Ophthalmology Flashcards
(53 cards)
Uvea components
- Iris
- Choroid
- Ciliary bodies
The uvea is the pigmented middle layer of the eyeball.
DDx for red eyes
1 eye:
- Allergic conjunctivitis
- Infective conjunctivitis
- Dry eyes
2 eyes
- Entropion
- Trichiasis
- CN VII palsy *
- Stromal keratitis*
- Epithelial keratitis*
- Acute angle closure glaucoma *
- Iritis
- Scleritis*
- episcleritis *
Entropion is a condition in which your eyelid, usually the lower one, is turned inward so that your eyelashes rub against your eyeball, causing discomfort.
Trichiasis is a medical term for abnormally positioned eyelashes that grow back toward the eye, touching the cornea or conjunctiva.
Vision loss: Diagnostic Q’s
HELLP
- Headache associated?Do an ESR urgently in all cases ≳50yrs old for ?GCA
- Eye movements hurt? (optic neuritis)
- Lights/flashes preceding visual loss? (detached retina)
- Like a curtain descending? Amaurosis fugax may precede permanent visual loss, eg from emboli/GCA.
- Poorly controlled DM and vitreous haemorrhage
Investigations for visual field loss
Binocular field defect –> Pattern of field loss
Monocular field loss –> Visual acuity –> Pinhole acuity –> RAPD swinging test –> Fundoscopy
In order to identify the location of the defect
Vision loss DDX
Neurological:
Post-chiasmal- Ischaemic (CVA / Haemorrhage), compression (tumour, abscess)
Chiasmal- Pituitary adenoma, craniopharyngioma, pituitary apoplexy (bleed)
Pre-chiasmal- AION, GCA, optic neuritis
Ophthalmic:
Vascular - Retinal artery occlusion, vein occlusion, vitreous haemorrhage (secondary to retinal detachment or new vessels in DM)
Mechanical - Trauma, retinal detachment
Define strabismus
Misalignment of eyes simultaneously under normal conditions. Classified as manifest or latent.
Children under 8yrs can suppress the worse image –> Amblyopia + squint
Adults cannot suppress –> Complain of double vision when strabismus present
What is ambylopia?
Vision development disorder where one eye doesn’t achieve normal visual acuity, even with glasses or contact lenses.
Children under 8yrs can suppress the worse image –> Amblyopia + squint
Adults cannot suppress –> Complain of double vision when strabismus present
What is anisocoria?
Anisocoria is a condition characterized by an unequal size of the eyes’ pupils.
20% of the population
Often entirely harmless, but can be a sign of more serious medical problems.
Diplopia DDx
Monocular diplopia: Cortical abnormality / Media opacity
Binocular diplopia: CN III palsy / CN IV palsy / Thyroid orbitopathy (tight inf rectus) / CN VI palsy / internuclear ophthalmoplegia
Ptosis DDx
Horner's syndrome (with myosis and anhydriasis) Bell's palsy Aponeurotic ptosis of levator insertion Myasthenia gravis (if worse at night) CN III palsy
OCT?
Optical coherence tomography
FFA?
Fundus fluorescein angiography
Use: Evaluates retinal ischaemia and leaky vessels
Retinoblastoma
Cause: 10% hereditary
PresentationL Strabismus, leukocuria, visual defects
Clinical diagnosis: Absent red reflex
Management:
Options depend on advancement of tumour e.g. external beam radiation therapy, chemotherapy and photocoagulation
Enucleation is becoming less popular.
Good prognosis
Bell’s palsy
What? CN VII Palsy
Tx:
- Initial: tape eyes down. Oily ointment to keep eyes lubricated. Should resolve over weeks
- Monitor for acute deterioration
5 types of lid lesions
Entropion Ectropion Trichiasis Blepharitis Stye
Ectropion vs endotropion
Ectropion = Inturning of eyelies
Mx: Lid tightening
Risk of corneal ulcer
Endotropion = Out-turning of eyelids
Mx: Tightening of muscles
Risk of conjunctivae exposure –> Infection and dry eyes
Trichiasis
What? Inwards growth of the eyelashes
Tx: Pluck eyelashes
Blepharitis
What? Inflammation of eyelid margins, leading to red eye
O/E: Crusty, and eyelashes clump together
Tx: Hot compress, lid hygiene. Abx ointment sparingly uses
Stye
What? Infected glands of eyelid due to blocked hair follicle. Classified as internal or external
O/E: Meibomian cyst (chalazion) residual mass from internal infection, hordeolum if external infection of sebum or sweat glands
Tx:
1st line: Immediate relief from eyelash plucking and hot compress. Topical Abx only recommended if associated conjunctivitis.
Chalazion: Spontaneous resolution in most, but come require surgical drainage
AMD
What? Bilateral degeneration of retinal photoreceptors that results in drusen formation
S/S:
- Blurring or distortion of vision (if sudden think choroidal neovascularisation or macula oedema)
- Progressive CENTRAL vision loss
Investigation:
1st line - Slit lamp
If neovascularisation AMD suspected? Fluorescein angiography
Progression:
- Health
- Early AMD (drusen seen on fundoscopy)
- Late AMD (wet or dry. Dry more common and has RPE atrophy with inflammation. Wet more concerning as risk of rapid vision loss, characterised by choroidal neovascularisation)
Treatment:
Early or Dry Late AMD? Specialist referral. High dose antioxidant and mineral supplementation. Monitoring with fluorescein angiography and OCT
Wet AMD? Intravitreal anti-vegf 4 weekly infections using monoclonal antibodies. 2nd line PDT
Open angle Glaucoma
What? Debris blocking the outflow of aqueous humours. Glaucoma is the consequence of increased IOP leading to optic nerve compression and disc atrophy
Risk factors: Male, 50+, myopia, black
S/S
- Initially asymptomatic
- Peripheral vision loss “scotoma”
- On fundoscopy disc changes (pale optic disc, increased cup:disc ration, disc margin haemorrhage, bayonetting of vessels)
- IOP >21 mmHg
1st line Investigations
- Tonometry for IOP-
- Fundoscopy for disc changes
- Slit-lamp
- Visual field loss
Management
REFER TO OPTHALMOLOGY
1st ine- PGA drops e.g. Latanoprost OD (SEL Brown pigmentation of iris, increased lash length)
2nd line - BB (e.g. Timolol) or Sympathomimetics (e.g. Brimonidine) or Carbonic anhydrase inhibitors (e.g. -“zolamide”. Note risk of sulphonamide reaction)
3rd line - Trabeculectomy or laser treatment
Acute angle closure glaucoma
What? Bowing of the iris blocking the aqueous aqueduct and increasing IOP
Risk factors: Women, 40yrs +, hypermetropia, asian
S/S
- Pain (abdo, eye, headache) + N/V
- Red eyes
- Fixed pupil
- Oedematous cornea
- Blurred vision, haloes
- Decreased VA
- IOP 50-80
Investigation:
1st line - Tonometry, fundoscopy, slit lamp, visual fields
Diagnostic - Gonioscopy
Management
1st line STAT latanoprost drops + IV Acetazolamide + Topical pilocarpine
Definitive: Urgent referral for Laser iridotomy
Cataract
What? Opacification of the lens due to fibre breakdown
Classification: Nuclear, cortical or subcapsular
Risk factors: UV exposure, 65+, Smoking, FH
Cause:
Ocular: Uveitis, Intraocular tumours, High hyopia
Systemic: DM, inherited (myotonic dystrophy, Down’s syndrome), maternal gestational infection (rubella, HSV, syphilis), Coritcal eye drops, steroids, radiation exposure
Presentation:
- Slow progressing
- Blurred vision, haloes around lights, glare from sun
- Colours muted
- Diplopia
Investigations
1st line- Visual acuity (reduced), Slit lamp (shows visible cataracts), Fundoscopy (red reflex reduced with normal fundus and optic nerve)
Treatment:
1st line- Conservative (stronger prescription)
2nd line- Referral for phaco.
Complications of phaco
- Posterior capsule opacification. Tx: YAG laser
- Retinal detachement
- Endophthalmitis
- Iris prolapse
- Cystoid macular oedema. Tx: topical steroids and NSAIDs
- Increased IOP
GCA
What? Large cells vasculitis (i.e. temporal arteritis) which gives the ophthalmic artery —> Arteritic Anterior Ischaemic optic neuropathy
Risk factors: Female or older age
Presentation: - Sudden vision loss, one eye at a time - Jaw claudication -Temporal tenderness -Headache - Weight loss -Fever (Diplopia)
O/E: Whole or altitudinal vision loss, RAPD, swollen optic disease.
Ix: ESR, CRP, temporal biopsy within 1 week of teroids
Treatment: Urgent referral to Ophthalmology. Urgent oral prednisolone.