Ophthalmology Flashcards

(53 cards)

1
Q

Uvea components

A
  1. Iris
  2. Choroid
  3. Ciliary bodies

The uvea is the pigmented middle layer of the eyeball.

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2
Q

DDx for red eyes

A

1 eye:

  • Allergic conjunctivitis
  • Infective conjunctivitis
  • Dry eyes

2 eyes

  • Entropion
  • Trichiasis
  • CN VII palsy *
  • Stromal keratitis*
  • Epithelial keratitis*
  • Acute angle closure glaucoma *
  • Iritis
  • Scleritis*
  • episcleritis *

Entropion is a condition in which your eyelid, usually the lower one, is turned inward so that your eyelashes rub against your eyeball, causing discomfort.

Trichiasis is a medical term for abnormally positioned eyelashes that grow back toward the eye, touching the cornea or conjunctiva.

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3
Q

Vision loss: Diagnostic Q’s

HELLP

A
  1. Headache associated?Do an ESR urgently in all cases ≳50yrs old for ?GCA
    1. Eye movements hurt? (optic neuritis)
    2. Lights/flashes preceding visual loss? (detached retina)
    3. Like a curtain descending? Amaurosis fugax may precede permanent visual loss, eg from emboli/GCA.
      1. Poorly controlled DM and vitreous haemorrhage
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4
Q

Investigations for visual field loss

A

Binocular field defect –> Pattern of field loss

Monocular field loss –> Visual acuity –> Pinhole acuity –> RAPD swinging test –> Fundoscopy

In order to identify the location of the defect

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5
Q

Vision loss DDX

A

Neurological:
Post-chiasmal- Ischaemic (CVA / Haemorrhage), compression (tumour, abscess)
Chiasmal- Pituitary adenoma, craniopharyngioma, pituitary apoplexy (bleed)
Pre-chiasmal- AION, GCA, optic neuritis

Ophthalmic:
Vascular - Retinal artery occlusion, vein occlusion, vitreous haemorrhage (secondary to retinal detachment or new vessels in DM)
Mechanical - Trauma, retinal detachment

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6
Q

Define strabismus

A

Misalignment of eyes simultaneously under normal conditions. Classified as manifest or latent.

Children under 8yrs can suppress the worse image –> Amblyopia + squint
Adults cannot suppress –> Complain of double vision when strabismus present

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7
Q

What is ambylopia?

A

Vision development disorder where one eye doesn’t achieve normal visual acuity, even with glasses or contact lenses.

Children under 8yrs can suppress the worse image –> Amblyopia + squint
Adults cannot suppress –> Complain of double vision when strabismus present

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8
Q

What is anisocoria?

A

Anisocoria is a condition characterized by an unequal size of the eyes’ pupils.

20% of the population

Often entirely harmless, but can be a sign of more serious medical problems.

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9
Q

Diplopia DDx

A

Monocular diplopia: Cortical abnormality / Media opacity

Binocular diplopia: CN III palsy / CN IV palsy / Thyroid orbitopathy (tight inf rectus) / CN VI palsy / internuclear ophthalmoplegia

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10
Q

Ptosis DDx

A
Horner's syndrome (with myosis and anhydriasis)
Bell's palsy
Aponeurotic ptosis of levator insertion
Myasthenia gravis (if worse at night)
CN III palsy
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11
Q

OCT?

A

Optical coherence tomography

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12
Q

FFA?

A

Fundus fluorescein angiography

Use: Evaluates retinal ischaemia and leaky vessels

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13
Q

Retinoblastoma

A

Cause: 10% hereditary

PresentationL Strabismus, leukocuria, visual defects

Clinical diagnosis: Absent red reflex

Management:
Options depend on advancement of tumour e.g. external beam radiation therapy, chemotherapy and photocoagulation
Enucleation is becoming less popular.

Good prognosis

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14
Q

Bell’s palsy

A

What? CN VII Palsy
Tx:
- Initial: tape eyes down. Oily ointment to keep eyes lubricated. Should resolve over weeks
- Monitor for acute deterioration

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15
Q

5 types of lid lesions

A
Entropion
Ectropion
Trichiasis
Blepharitis
Stye
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16
Q

Ectropion vs endotropion

A

Ectropion = Inturning of eyelies
Mx: Lid tightening
Risk of corneal ulcer

Endotropion = Out-turning of eyelids
Mx: Tightening of muscles
Risk of conjunctivae exposure –> Infection and dry eyes

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17
Q

Trichiasis

A

What? Inwards growth of the eyelashes

Tx: Pluck eyelashes

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18
Q

Blepharitis

A

What? Inflammation of eyelid margins, leading to red eye

O/E: Crusty, and eyelashes clump together

Tx: Hot compress, lid hygiene. Abx ointment sparingly uses

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19
Q

Stye

A

What? Infected glands of eyelid due to blocked hair follicle. Classified as internal or external

O/E: Meibomian cyst (chalazion) residual mass from internal infection, hordeolum if external infection of sebum or sweat glands

Tx:
1st line: Immediate relief from eyelash plucking and hot compress. Topical Abx only recommended if associated conjunctivitis.
Chalazion: Spontaneous resolution in most, but come require surgical drainage

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20
Q

AMD

A

What? Bilateral degeneration of retinal photoreceptors that results in drusen formation

S/S:

  • Blurring or distortion of vision (if sudden think choroidal neovascularisation or macula oedema)
  • Progressive CENTRAL vision loss

Investigation:
1st line - Slit lamp
If neovascularisation AMD suspected? Fluorescein angiography

Progression:

  1. Health
  2. Early AMD (drusen seen on fundoscopy)
  3. Late AMD (wet or dry. Dry more common and has RPE atrophy with inflammation. Wet more concerning as risk of rapid vision loss, characterised by choroidal neovascularisation)

Treatment:
Early or Dry Late AMD? Specialist referral. High dose antioxidant and mineral supplementation. Monitoring with fluorescein angiography and OCT
Wet AMD? Intravitreal anti-vegf 4 weekly infections using monoclonal antibodies. 2nd line PDT

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21
Q

Open angle Glaucoma

A

What? Debris blocking the outflow of aqueous humours. Glaucoma is the consequence of increased IOP leading to optic nerve compression and disc atrophy

Risk factors: Male, 50+, myopia, black

S/S

  • Initially asymptomatic
  • Peripheral vision loss “scotoma”
  • On fundoscopy disc changes (pale optic disc, increased cup:disc ration, disc margin haemorrhage, bayonetting of vessels)
  • IOP >21 mmHg

1st line Investigations

  • Tonometry for IOP-
  • Fundoscopy for disc changes
  • Slit-lamp
  • Visual field loss

Management
REFER TO OPTHALMOLOGY
1st ine- PGA drops e.g. Latanoprost OD (SEL Brown pigmentation of iris, increased lash length)
2nd line - BB (e.g. Timolol) or Sympathomimetics (e.g. Brimonidine) or Carbonic anhydrase inhibitors (e.g. -“zolamide”. Note risk of sulphonamide reaction)
3rd line - Trabeculectomy or laser treatment

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22
Q

Acute angle closure glaucoma

A

What? Bowing of the iris blocking the aqueous aqueduct and increasing IOP

Risk factors: Women, 40yrs +, hypermetropia, asian

S/S

  • Pain (abdo, eye, headache) + N/V
  • Red eyes
  • Fixed pupil
  • Oedematous cornea
  • Blurred vision, haloes
  • Decreased VA
  • IOP 50-80

Investigation:
1st line - Tonometry, fundoscopy, slit lamp, visual fields
Diagnostic - Gonioscopy

Management
1st line STAT latanoprost drops + IV Acetazolamide + Topical pilocarpine
Definitive: Urgent referral for Laser iridotomy

23
Q

Cataract

A

What? Opacification of the lens due to fibre breakdown

Classification: Nuclear, cortical or subcapsular

Risk factors: UV exposure, 65+, Smoking, FH

Cause:
Ocular: Uveitis, Intraocular tumours, High hyopia
Systemic: DM, inherited (myotonic dystrophy, Down’s syndrome), maternal gestational infection (rubella, HSV, syphilis), Coritcal eye drops, steroids, radiation exposure

Presentation:

  • Slow progressing
  • Blurred vision, haloes around lights, glare from sun
  • Colours muted
  • Diplopia

Investigations
1st line- Visual acuity (reduced), Slit lamp (shows visible cataracts), Fundoscopy (red reflex reduced with normal fundus and optic nerve)

Treatment:
1st line- Conservative (stronger prescription)
2nd line- Referral for phaco.

Complications of phaco

  • Posterior capsule opacification. Tx: YAG laser
  • Retinal detachement
  • Endophthalmitis
  • Iris prolapse
  • Cystoid macular oedema. Tx: topical steroids and NSAIDs
  • Increased IOP
24
Q

GCA

A

What? Large cells vasculitis (i.e. temporal arteritis) which gives the ophthalmic artery —> Arteritic Anterior Ischaemic optic neuropathy

Risk factors: Female or older age

Presentation:
- Sudden vision loss, one eye at a time
- Jaw claudication
-Temporal tenderness
-Headache
- Weight loss
-Fever
(Diplopia)

O/E: Whole or altitudinal vision loss, RAPD, swollen optic disease.

Ix: ESR, CRP, temporal biopsy within 1 week of teroids

Treatment: Urgent referral to Ophthalmology. Urgent oral prednisolone.

25
Blepharitis
What? Lid inflammation Cause? Staph infection, seborrhoeic dermatitis, rosacea Presentation: Burning, itching red margins of eyes with scales on lashes Clinical Dx Tx: Good eye hygiene w/ baby shampoo. If child with blepharokeratitis, consider adding erythromycin
26
Dry eyes
Presentation: Red eyes, gritting. If unilateral with incomplete closure, think CN VII palsy Tx: Long term ocular lubricant i.e. Viscotears in day, lacrilube at night Risk: Corneal ulcer
27
Thyroid Eye disease
aka TAO or Grave's eye disease Who? 25-50% of Grave's patients get it Cause: Glycosaminoglycan and collagen deposition in the extra-ocular muscles in response to inflammation. S/S: - Exophthalmos - Conjunctival oedema "chemosis" - Ophthalmoplegia - Optic disc swelling - Unable to close eyes --> Dry and red eyes --> Risk of exposure keratopathy Progression: NO SPECS Investigations: TFTs, Antibody screen Mangement: Topical lubricants, Radiotherapy, surgery, steroids. Monitor for indication to urgently review e.g. - Disc swelling - Unexplained deterioration in vision, colors - Corneal opacity or exposure
28
Infective Conjunctivitis
Causative agent: Bacterial- Staph A Viral - Adenovirus Ophthalmia neonatorum - Chlamydia or gonorrhoea. Presentation of bacterial: Sore, red eyes. Purulent discharge, eyes stuck together in morning Viral presentation: Sore, red eyes. Serous discharge, recent URTI, pre-auricular lymph nodes. Ix: History and exam. Swabs rarely required. Tx: 1st line Conservative for 1-2 weeks. No contact lens, do not share towels. No school exclusion required, consider staying off nursery. 2nd line - Topical Abx e.g. Chloramphenicol drops 3rd line: Topical fusidic acid (for preg women)
29
Allergic Conjunctivitis
Associated with atopy, often seen in hayfever context S/S - Red, swollen eyes - Itch! - Eyes stinging > discharge - Swollen eyelids - Seasonal (due to pollen) or perennial (due to allergen exposure e.g. dust mite) Clinical diagnosis Management: 1st line: Allergen avoidance and Topical/systemic antihistamine 2nd line - Topical mast cell stabiliser e.g. Na cromoglicate and nedocromil
30
Orbital cellulitis
What? Infection of the fat and muscle posterior to the orbital septum, but not the globe Cause: Local spread from URTI / sinus/ ear or facial infection. Bacterial agent e.g. Stept, staph, Hib Presentation: - Opthalmoplegia - Red/swollen eye - Reduced visual acuity - Proptosis - Severe ocular pain - Eyelid oedema and ptosis Ix for ALL suspected FBC; WBC, ESR, CRP Ophthalmic assessment - Decreased vision, RAPD, proptosis, oedema, erythma, dysmotility CT with contrast- To negate preseptal cellulitis Culture of blood and eye swabs Management: URGENT admission and senior review. IV Ceftriaxone and oral metronidazole (total duration 7 days) Prognosis: High mortality. Risk of increased IOP and optic nerve damage
31
Keratitis
What? Inflammation of the cornea Cause: Bacterial - Staph A typically. Viral- HSV Amoebic - Acanthamoebic keratitis from soil or contaminated water Parasitic - Onchocercal keratitis in "river blindness" Chemical in exposure keratitis CL - "Clare" due to pseudomonas aeruginosa- contact lens-induced acute red eye S/S - Pain - Erythema - Photophobia - Foreign body/gritty sensation - Epiphora - xs watering Ix: Opthalmologist performs corneal scrape Management If CL wearer, then same-day referral for slit lamp to exclude microbial cause 1. Stop using CL until resolve. Topical Abx using quinolones. Cyclopegics for analgesia A cycloplegic eye drop is an eye drop that temporarily paralyzes the ciliary body, allowing a doctor to fully measure a patient's vision problem + analgesia Complications: - Corneal scarring - Performation - Endophthalmitis - Visual loss Endophthalmitis is inflammation of the interior cavity of the eye, usually caused by infection. It is a possible complication of all intraocular surgeries, particularly cataract surgery, and can result in loss of vision or loss of the eye itself. Conjunctiva -> cornea > uvea >endophthalmitis
32
HSV keratitis
Presentation - Dendritic corneal ulcer - Red, painful eye - Photophobia - Euphoria - Decreased VA Investigation Fluorescein dye show dendritic ulcer Treatment 1st line: Ophthalmic referral for topical aciclovir Risk: Reduced corneal sensation overtime
33
``` Iritis / Anterior Uveitis cause sx ix mx ```
Cause: - 50 % idiopathic. - Infectious e.g. HSV, VZV, TB, syphilis - Non-infectious e.g. associated with HLA-B27 linked conditions (Ank Spond, MS , IBD, Sarcoid) Symptoms: Acute onset of.... - Unilateral red, painful eye - Pupil smaller on red eye side - Photophobia - Blurred vision - Lacrimation - Hypopyon (inflammatory cells in the anterior chamber of the eye. It is an exudate rich in white blood cells, seen in the anterior chamber, usually accompanied by redness of the conjunctiva and the underlying episclera.) suggests Infection Investigation 1st line: Eye exam (slit lamp for cells and flare in ant chamber) - No fluoroescein stain -Normal eyelid closure Treatment 1st line: Urgent review by ophthalmology for... cyclopegics (pupil dilator to releive pain and photopobia. E.g. cyclopentolate, atropine) and steroid eye drops If hypopyon present, immediate Abx injections
34
Scleritis
Cause: 1/3 associated with systemic autoimmune disease (GPA, SLE, RA). Local causes of Herpes zoster, trauma, surgery Classification: Non-necrotising (75%) and necrotising S/S - Severe ocular pain - Unilateral red eye (can be sectoral) - Decreased VA - ? Iris may be small / photophobia Ix: CRP, ESR, Rheumatoid tests, FBC Mx: Urgent referral (investigate systemic association + anti-inflammatory or immunosuppressive meds) Complications: - Keratitis - Posterior scleritis (seen as choroidal folds on fundoscopy) - Scleromalacia perforans (progressive scleral thinning)
35
Episcleritis
What? Inflammation of the upper layer of sclera. Often bilateral Cause: Idiopathic Presentation: Redness, mild-mod discomfort, grittiness +/- photophobia. VA normal. DDx: - Painful? Think scleritis. Management: - Self-limiting so topical/oral NSAIDs +/- week TOP steroid (FML)
36
Vitreous haemorrhage
Cause: DM, CRVO, BRVO, spontaneously in healthy people Symptoms: Floaters+++ then steadily increasing misty vision over hrs/days. Signs: No red reflex No RAPD Management: Clears on own over days-months
37
Diabetic Retinopathy
Symptoms: Vision loss and floaters Signs on fundoscopy: - Micro-aneurysms - Haemorrhages - Exudates - IRMA 9 (intraretinal microvascular abnormalities) - cotton wool spots - Venous beading Classification 1. Non-proliferative diabetic retinopathy (NPDR): Mild, Mod, Severe -Mild NPDR • 1 or more microaneurysm - Moderate NPDR • microaneurysms • blot haemorrhages • hard exudates • cotton wool spots, venous beading/looping and IRMA less severe than in severe NPDR - Severe NPDR • blot haemorrhages and microaneurysms in 4 quadrants • venous beading in at least 2 quadrants • IRMA in at least 1 quadrant 2. Proliferative diabetic retinopathy (PDR) 3. Advanced diabetic eye disease Management No DR--> Review in 12 months Non-proliferative --> Mild and Mod (6 month review), Severe (Review in 1-4 month. Do fundus fluorescein angio to assess ischaemia) Proliferative --> Urgent review in 2 weeks for intravitreal anti-VEGF or PRLP Advanced --> Emergency referral for vitrectomy Diabetic macular oedema --> intravitreal anti-VEGF or laser coagulation Screening: For all diabetics >12 years old with annual appt ``` Complication: Rubeosis iridis (blood vessels growing near iris) is glaucoma risk factors ```
38
Retinal detachment
Cause: Often spontaneous. Associated with high myopia and trauma Presentation: 4 F's - Floaters - Flashes - Field loss - Fall in acquity (may be normal in initial stages) Clinical findings - Loss of red reflex - RAPD if the central retina detached Fundoscopy shows grey, opalescent retina ballooning forward Tx: URGENT referral for laser photocoagulation therapy and surgery (vitrectomy, gas tamponade, silicone oil). Rest post-op is key! Prognosis: Re-detachement in 5-10%. Determined by nature of detachment and time to Tx
39
Retinitis Pigmentosa
What? Inherited degeneration of the retina Associated with Alports syndrome etc Presentation: Loss of night vision --> Loss of daytime central and peripheral vision Ix: Fundoscopy shows mottled RPE and blacked peripheral retina Management: Novel treatments with neural prosthetics Prognosis: 25% retain reading, reduced VA and visual acuity
40
Retinal artery occlusion
Cause: Secondary to background vasculopathy OR vasculitis Presentation: Sudden, unilateral vision loss with no pain. Vision loss of whole eye = CRAO, partial vision loss = BRAO. Investigation: RAPD present. Fundoscopy shows pale optic disc with "cherry red spot" at the macula in CRAO. Treatment: Immediate/emergency - Ocular massage, aqueous drainage via surgery, intraocular hypotensives Prevention - CV risk factors addressed Risk management - US carotid to screen for stroke.
41
Retinal Vein Occlusion
Cause: Increased age, CVS risk factors Classification: CRVO or BRVO, either ischaemic or non-ischaemic Clinical features: Painless, unilateral vision loss (no loss of vision in macula sparing CRVO) Investigations: RAPD present. Fundoscopy shows haemorrhages and hyperaemic retina. Fundus fluorescein angiogram assesses ischaemia. Management: Refer to opthalmology to manage complication - no vision loss = Closely monitor - Vision loss = Anti-VEGF then Dex - Retinal neovasculisation = Photocoagulation Complications: - Retinal neovascularisation - Chronic macula oedema
42
Bell's Palsy
What? CN VII palsy Tx: Initial: tape eyes down. Oily ointment to keep eyes lubricated. Should resolve over weeks Monitor for acute deterioration
43
Optic neuritis
Cause: MS*****, DM, Syphilis Presentation: Red desaturation (poor colour discrimination), Unilateral gradual vision loss, painful eye movements, OE: - RAPD - Fundoscopy can be normal. Can be telangiectasia, disc swelling then optic atrophy Ix: MRI for dymyelinating plaques Mangement: 1st line: W/W 2nd line: High-dose IV methylprednisolone for 72 hours then ORAL prednisolone for 11 days prognosis: 4-6 weeks recovery
44
Eye trauma
On examination: Subconjunctival haemorrhage: Red eye with edge at cornea Corneal foreign body: Fluorescein stain Hyphaema: Reduced VA, Round pupil, blood in anterior compartment Penetrating eye injury: Reduced VA, stain with Fluorescein Orbital fracture: All normal BUT reduced eye movements VA - visual acuity A hyphema is a pooling or collection of blood inside the anterior chamber of the eye (the space between the cornea and the iris). The blood may cover most or all of the iris and the pupil, blocking vision partially or completely. A hyphema is usually painful.
45
Sign of positive RAPD
Using swinging flashlight test Positive result: When you swing from one eye to the other , there should be a slight increased constriction then dilation back to previous size. When injury to optic nerve or retina present, when swinging light to injured pupil it dilates.
46
Cover Test
Indication: Squint or diplopia Tropia = Manifest strabismus = shift in fixation Method: Over one eye and watch other for movement. Results: Horizontal movement = Esotropia (unoccluded eye movement laterally) or exotropia (unoccluded eye movement medially) Vertical movement = = Hypertropia (unoccluded eye movement down) or hypotropia (unoccluded eye movement up) No movement = Patient orthotropic or covered eye fixation
47
Alternate cover test
Test of "phoria" that happen in latent stabismus Method: Move occluder quickly from one eye to another, whilst patient focusses on torch 33cm infront of them centrally
48
``` Fundoscopy findings: No RR Pale optic disc Ill-defined margin of optic disease Cupping Cotton wool spots / neovascularistion AV nipping / Flame haehmorrhages Retinal pallor / cherry red spots Macula drusen ```
No RR - Vitreal haemorrhage, retinoblastoma, cataracts Pale optic disc- Optic neuritis (MS), Retinal artery occlusion Ill-defined margin of optic disease - Papilloedema Cupping - Glaucoma Cotton wool spots / neovascularistion - DM, Retinal vein occlusion AV nipping / Flame haehmorrhages - Hypertension Retinal pallor / cherry red spots - Retinal artery occlusion Macula drusen - AMD
49
Subconjunctival haemorrhage
Cause: Idiopathic, warfarin, HTN, trauma, valsava Ix: BP check. If due to trauma or foreign, full ophthalmic assessment Mx: Reassure, will resolve in a few weeks.
50
Corneal abrasion
Symptoms: Pain Ix: Fluorescein dye - Mx: Antibiotics ointment. Pressure patch? Advise will be sore for 24-48 hours, consider analgesia Risk: Recurrent corneal eroisions.
51
Penetrating eye disease
Mx: NOTHING in primary care, no eating or drinking. Refer to ophthalmology
52
Chemical injury
Mx: 1. IMMEDIATE irrigation with saline (1L at a time), until pH neutralised 2. Slit lamp exam No need to refer if: Minimal discomfort, VA normal, cornea clear with no staining
53
Drugs causing ocular problems
Cataracts -steroids Corneal opacities - amiodarone - indomethacin Optic neuritis - ethambutol - amiodarone - Metronidazole Retinopathy -Hydroxychloroquine (Plaquenil), quinine