Flashcards in opioids Deck (15):
opioids have more affinity for what isomer?
opioid receptors are primarily responsive to 3 endogenous ligands...
opioids...(what form attached to receptor?)
potency correlates with...
opioid receptors primarily located on...
-the peripheral ends of primary sensory (sensory afferent dorsal) neurons
-rexed lamina II and III
opiod receptor activation... (1, 2)
1. decreases neurotransmission
2. inhibits the release of excitatory neurotransmitters (ACh, Dopa, NE, substance P)
G-protein coupled receptors
epidural space (between ligamentum flavum and dura) contains...
-fat, veins, spinal nerve roots
SA space (spinal space) contains...
-spinal cords, CSF, spinal nerve roots
- >1ml will increase ICP
cephalad spread depends on...
classic 4 opioid SE
Morphine and N2O
excitatory response to opioids in the ANS component of the Edinger-Westphal (CN III) nucleus
treatment of biliary spasm d/t opioids