opioids Flashcards Preview

Pharmacology > opioids > Flashcards

Flashcards in opioids Deck (15):
1

opioids have more affinity for what isomer?

L- isomer

2

opioid receptors are primarily responsive to 3 endogenous ligands...

-endorphins
-dynorphins
-enkephalins

3

opioids...(what form attached to receptor?)

ionized

4

potency correlates with...

receptor affinity

5

opioid receptors primarily located on...

-the peripheral ends of primary sensory (sensory afferent dorsal) neurons
-substantia gelatinosa
-rexed lamina II and III

6

opiod receptor activation... (1, 2)

1. decreases neurotransmission
2. inhibits the release of excitatory neurotransmitters (ACh, Dopa, NE, substance P)

7

G-protein coupled receptors

-mu
-delta
-kappa


(decrease cAMP)

8

epidural space (between ligamentum flavum and dura) contains...

-fat, veins, spinal nerve roots
-20ml

9

SA space (spinal space) contains...

-spinal cords, CSF, spinal nerve roots
- >1ml will increase ICP

10

cephalad spread depends on...

lipid solubility

11

classic 4 opioid SE

-pruritis
-urinary retention
-ventilatory depression
-sedation

12

Morphine and N2O

CV depression

13

miosis d/t

excitatory response to opioids in the ANS component of the Edinger-Westphal (CN III) nucleus

14

treatment of biliary spasm d/t opioids

-glucagon 1-2mg
-naloxone 0.01mg
-nitroglycerine 25mcg

15

CTZ (NV)

-area post rems
-floor 4th ventricle