Opioids Flashcards by Brooke Katherine

Q

dilaudid onset

A

15 mins

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Q

dilaudid duration

A

2-4 hrs

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Q

dilaudid dose

A

0.01-0.02 mg/kg

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Q

fentanyl onset

A

1-2 min

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Q

fentanyl duration

A

20-40 min

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Q

fentanyl metabolism

A

significant first pass in the lungs

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Q

fentanyl metabolism is dependent on

A

hepatic blood flow

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Q

sufentanil metabolism

A

significant first pass in lungs

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Q

sufentanil dose

A

0.05-0.2 mcg/kg/hr

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Q

when to turn off sufentanil before emergence

A

30 mins prior

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Q

alfentanil onset

A

super fast

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Q

why is alfentanil a fast onset

A

90% non-ionized
low pKa

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Q

alfentanil dose for blunting SNS

A

15mcg/kg

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Q

alfentanil dose gtt

A

25-50 mcg/kg/hr

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Q

alfentanil dose for loss of consciousness

A

150-300 mcg/kg

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Q

alfentanil metabolism

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A

liver

Q

alfentanil drug interaction and effect

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A

erythromycin- prolongs metabolism and resp. depression

Q

remi metabolism

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A

ester link
hydrolyzed by blood and tissue esterases

Q

when to stop remi prior to emergence

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A

10 min

Q

remi dose

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A

0.05-0.2 mcg/kg/min

Q

methadone MOA

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A

opioid receptor agonist and NMDA antagonist

Q

methadone duration and reason

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A

24-36 hr
highly protein bound

Q

methadone side effect

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A

prolonged QT

Q

tramadol drug interaction

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A

SSRIs- serotonin syndrome

tramadol structure

synthetic codeine

tramadol MOA

stimulated alpha 2

tramadol half life

5-6 hrs

tramadol 3 side effects

seizures hypoglycemia hyponatremia

demerol drug interaction

MAOIs- serotonin syndrome

demerol metabolite

normeperidine 1/2 potency lowers seizure threshold

naltrexone duration

24 hours

narcan dose

0.4 mg

narcan side effect

pulm edema

narcan duration

less than 1 hr may need to redose