Opioids - Review, General info Flashcards Preview

Summer Pharm (2016) ** > Opioids - Review, General info > Flashcards

Flashcards in Opioids - Review, General info Deck (98)
Loading flashcards...
1

firing of a neuron that is not indicative of of physical damage, but is a pathalogical firing

Neuropathic pain

2

Pain out of proportion to noxious stimuli

Hyperalgesia

3

Pain evoked by a non-noxious stumuli

Allodynia

4

pain with no apparent stimuli - it is NERVE pain

spontaneous pain

5

Peripheral nociceptive neuron activated by intense noxious stimimuli (tissue damage) via 

*  Mechanical * thermal * chemical 

6

slow conduction, dull, burning, diffuse

non-mylinated C fibers

7

fast conduction - sharp and well localized

A-delta fibers

8

nociceptiv impulse depends on the balance between

excitatory and inhibatory receptors

9

excitatory cation channel activated by: * Protons * heat * capsaisin * Endovanilloids

TRIP1

10

hyperpolarization related to opioid receptor activation

cells will need a stronger stimulus to fire

11

promotes depolarization and stimulates pain

Bradykinin and Prostaglandins

12

Area of dorsal horn that is very rich in opioid peptides and receptors 

substantia geletinosa

13

Lamina for A delta fibers

Lamina I and V

14

Lamina for C fibers

Lamina II and III (substantia gelatinosa)

15

Located in lamina II and III

Substantia gelatinosa

16

where do opioids act at the brain level

pre and post synaptically to activate descending inhibatory pathways

17

where do opioids act at the spinal cord level

work directly on the dorsal horn of the spinal cord

18

where do opioids act at the periphery level

act on peripheral teminals of nociceptive neurons

19

why is the perception of noxious stimuli not the same as pain?

it is lacking the emotional component

20

Opioids can change patients ___ without necessarily changing the patients ability to _____ noxious stimuli

* tolerance of pain  * perceive   ie- they can still tell you where the wound is

21

The main use of opioids on anestehsia 

Attenuate the SNS response to noxious stimuli- Laryngoscopy

22

opoids and inhaled anesthetics

act as an adjunct allowing for less use of inhaled agent

23

natrurally occuring drugs derrived from opium from the poppy plant

Opiate * Morphine * Codeine

24

Opioids produce analgesia without loss of

* Touch * Propioception * Conciousness

25

naturally occuring opioids

Morphine

26

semisynthetic: analogs of morphine

heroine dihydromorhone codeine

27

Synthetic Opioids

* Exogenous  Has 4 classifications * agonist * partial aginist * mixed agonist/antagonist * antagonist

28

Synthetic antagonist

Narcan

29

can reach maximum eficacy on dose response curve their potency is what varries

Synthetic agonists (full)

30

will have a ceiling effect cannot reach maximum effect on dose response curve

Synthetic partial agnosts