Opthalmology Flashcards

(143 cards)

1
Q

Opthalmoscopy: what must you do first.

  • what kind of agent
  • warning
  • C.I.
A

Dilate the pupil with parasympathomimetic (Tropicamide - lasts for 20 min - 12h)

Warn about driving as affects ciliary muscles inhibiting accommodation for near vision

Head injury (require pupil reflex)

Risk of closed angle glaucoma

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2
Q

4 C of normal Optic disc

A

Colour - yellow/orange

Contour - well defined, flat

Cup - small depression in centre of optic disc. less than 0.5 of disc diameter. No vessels or nerve fibres

Circulation - not tortuous, not attenuated (reduced)

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3
Q

What is red reflex

A

reflection from orange retina

Sign of cataract or central tumour

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4
Q

Pale disc?

A

optic atrophy - prev damage to nerve

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5
Q

Elevated/swollen disc

A

papilloedema

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6
Q

Large cup

A

If over 50% of dis diameter -> chronic glaucoma

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7
Q

Attenuated (reduced vessels)

A

Central retinal artery occlusion

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8
Q

What is the optic disc?

A

The blind spot.

This is point of entry of BV and Optic nerve

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9
Q

What is Macula and Fovea

A

Area where visual acuity is the highest. Just temporal to Optic disc. No vessels.

Centre is Fovea - Just Cone (colour and acuity) receptors

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10
Q

Retina

  • What
  • abnormal signs
A

Layer at the back of eyeball with photoreceptors

Haemorrhages, Exudates, Drusen (lipid deposits), Scarring, Retinitis Pigmentosa (loss of photoreceptors - black deposits)

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11
Q

Signs of vascular disease in Retina

A

Flame haemorrhages: superficial (Retinal vein occlusion)

Blot haemorrhages: deeper (Diabetic)

Dot haemorrhage: micro aneurysms (Diabetic)

Preretinal (boat shaped) haemorrhages (Diabetic, SAH)

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12
Q

Hard Vs Soft exudate

A

Hard (true exudate) = leakage of fluid into retina

Soft = micro infarcts & cotton wool spots (fluffy/white)

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13
Q

What are drusen

A

Lipid deposits - Pale, Round, Grey spots seen at the macula

Seen in elderly, age related macula degeneration

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14
Q

What is retinitis Pigmentosa?

What is seen

A

Inherited retinal degeneration, spidery black pigmentation in peripheral retina

Tunnel vision and night blindness

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15
Q

Scotoma (relative & absolute)

Quadra/Hemianopia

A

Scotoma = blind spot

  • Relative = decrease
  • Absolute = total

Quarter loss /
Half loss

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16
Q

What is meant my congruity?

A

How well formed the shape of the defect is. gets better closer to visual cortex

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17
Q

Bitemporal hemianopia

  • Cause
  • diagnosis
A

compression of the optic chiasm

upper more than lower = pituitary tumour

lower more than upper = craniopharyngioma

Remember this as UP London City

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18
Q

Homonymous quadrantanopia

A

superior homonymous quadrantanopia = lesion in temporal lobe

inferior homonymous quadrantanopia = lesion in the parietal lobe

PITS - parietal inferior temporal superior

incongruous = optic tract

congruous = the optic radiation/cortex

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19
Q

Homonymous hemianopia (ssam e.g. left field in both eyes)

A

Brain lesion (Bleed or tumour) on Contralateral side to lesion

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20
Q

Central scotoma

A

Lesion in Optic nerve -> Optic neuritis

e.g demyelination in MS, toxins like methyl-alcohol

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21
Q

What is slit lamp for

A

Visualising Anterior segment of eye (vitreous body/lens)

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22
Q

Slit lamp signs

A

Flare = inflammation

Cells in vitreous (tobacco dust) = retinal tear

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23
Q

Outer layer of eye

A

Cornea over lens, sclera over rest

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24
Q

Anterior segment

  • where
  • what humor
A

Anterior to lens

Contains aqueous humor

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25
Posterior segment - where - layers - Humor
Behind lens Sclera (outer), choroid, Retina Vitreous humour
26
What adjusts the lens
Ciliary muscles and fibres
27
What is Macula and fovea.
Macula is thickest part of retina with high conc of cones (c for colour) Small depression in centre of macula
28
Photoreceptor types
Cones: Colour vision and acuity, central retina Rods: night vision, outer retina
29
Referral for: - Sudden loss of vision - Sudden diplopia - Gradual loss of vision
Urgent telephone to Opthal for sudden acute changes Gradual = optometrist
30
Cause of Gradual visual loss
Cataract, Glaucoma, Age-related Macula degeneration (chronic + degenerative)
31
What is used for visual acuity
Snellen chart - Do test at 6m - Top line is what can be done at 60m (6/60 if can read) second from bottom is what should be read at 6m. This is aim (6/6)
32
White discolourations of pupil?
Cataract
33
What is cataract RF
Clouding in lens. progressive Aging, Downs, sunlight, smoking
34
Job of lens
Accommodation to focus vision
35
Presentation of Cataract
``` Change in vision - Myopia (short-sightedness) - Blurred vision - glare - double vison - poor vision in bright light - Loss of colour vision Changing astigmatism ```
36
Cataract surgery - when - anaesthesia - what is done
Opacity impacts everyday life Local Lens is remover through small incision and intaocular lens inserted
37
Cataract surgery complications
Vitreous prolapse/rupture Intraocular haemorrhage Post-op: inflammation, lens dislocation, infection
38
What is the optic 'angle'
Space between the posterior surface of cornea and anterior surface of Iris (coloured bit) where aqueous humour leaves the eye
39
Glaucoma classifications - angle - cause - onset
Open Vs closed angle Primary Vs Secondary Acute Vs Chronic
40
Aqueous production + function * note don't confuse with vitreous
Made by the ciliary body Circulates and nourishes lens Leaves via angle and enters episcleral veins
41
Intra-ocular pressure
Balance between aqueous production and drainage normal 21mmHg
42
Chronic open angle glaucoma (most common glaucoma) - def - type of visual loss
Chronic, progressive changes in optic nerve causing visual field loss Peripheral loss (Tunnel vision)
43
Triad of signs/sympt in Glaucoma
1) Raised IOP - over 21mmHg (Eye ache) 2) Abnormal disc (inc cup, haemorrhage, loss of neurones) 3) VF defect (tunnel) Chronic may be asymptomatic
44
Chronic open angle glaucoma pathophys
alteration of trabecular meshwork in angle impairing outflow of aqueous
45
Chronic open angle glaucoma RF
``` Age over 40 Afro-Caribbean FH Steroids Vascular disease (HTN, DM. Thought to be possible cause for trabecular dysfunction) ```
46
Optic disc in Chronic open angle glaucoma
Severe cupping of optic disc (over 0.5 of optic disc)
47
Vision loss in Chronic open angle glaucoma. - Pattern - When
Progressive into tunnel pattern of vision Asymptomatic/Acuity preserved until late.
48
Screening methods for Chronic open angle glaucoma
IOP - inc (using tonometry) VF testing - reduced Fundoscopy - cupping All 3 to reduce false +ve rate
49
Chronic open angle glaucoma management (*note, observe is done 1st)
Drops: - PG analogues (latanoprost) 1st line - Beta block (timolol) Laser therapy (target ciliary body) Surgical trabeculaectomy
50
Management strategy in Chronic open angle Glaucoma
Counsel (life long Tx, driving) Target 20% reduced IOP PG agonist/BB 1st line Review 6 weekly
51
Prostagalndin analogue mechanism
Increase trabecular (uveoscleral) outflow E.G Latanoprost
52
Beta blocker mechanism
Decrease aqueous prod by blocking symp fibres in Ciliary body E.G Timolol SE: bradycard, hypotension, bronchospasm CI: Heart block, COPD, Asthma
53
Carbonic anhydrase inhibitors mechanism
Decrease aqueous production E.G: Dorzolamide CI: renal & liver failure
54
Age related macular degeneration types
Retinal atrophy (dry) - slow progression/deterioration ATROPHIC New vessel growth under Retina (wet) - fast degeneration NEOVASCULARISATION
55
What does visual acuity rely on
1) Functional photoreceptors (Rods/cones) 2) Healthy retinal pigment epithelium 3) Perfusion of Choroid (capillary layer)
56
What is 1st sign of Age related macular degeneration & what is it
Drusen Lipid waste material from photoreceptors accumulating in and below Retinal Pigment Epithelium (white deposits)
57
Dry AMD - Features - Progression
Ophthalmoscope: Atrophy of retinal pigment epithelium (can see choroidal arteries underlying) Visual field loss: central scotoma, preserved peripheral vision Frequently deteriorate, Require vision aids Not much can be done to Tx
58
Wet AMD - Features - Management
Opthalmoscope: - Leaking vessels below retina - Exudates, haemorrhages and scarring Visual Field loss - localised retinal detachment = distorted central vision - eventual central scotoma Intravitreal anti-TNF-beta, anti-VEGF
59
Age related macular degeneration RF
sunlight, smoking, older, fam Hx | STOP SMOKING!!!
60
Sudden visual loss causes
Tend to be Vascular: - Branch/Central retinal artery/vein occlusion - Anterior ischemic optic neuropathy Inflammatory: - Optic neuritis (multiple sclerosis) Retinal detachment
61
Blood supply to eye
From internal carotid and also middle meningeal Opthalmic artery is branch of internal carotid. Central retinal comes off this
62
Branch and Central retinal artery occlusion - Presentation - Cause - Management
Sudden total loss of vision (central) or loss of top/bottom half (branch) Relative afferent pupil defect (Marcus Gunn - swinging flashlight) Embolic (carotid atheroma, cardiac origin) GCA Thrombophilic conditions Cant be improved. Secondary prevent: aspirin, smoking, HTN, Cholesterol, AF
63
Branch and Central retinal artery occlusion Opthalmoscopy
Embolus visible at optic disc Thin (attenuated) Retinal arteries Retinal oedema (pallor temporal to disc) After 3 months disc becomes pale (necrosis)
64
Investigation retinal emboli
Carotid doppler (stenosis over 70% needs stent) Fasting serum lipids (cholesterol) ± Clotting screen, CT head
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Transient monocular visual loss = Pres Investigate Tx
Amaurosis Fugax (ocular TIA) Curtain over vision for around 30 mins Carotid doppler, USS Aspirin, Clopidogrel
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Micro-aneurysm complication Tx of microaneurysm and management of complication
vitreal leak = reduced vision Laser around margin, investigate source: HTN, emboli Watch/wait, vitrectomy (remove vitreous from eye)
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Branch retinal vein occlusion - Pres - Cause - Opthalmoscope
Sudden Visual blurring, Visual field defect (blood leak) Athero, HTN, DM, Smoking, Thrombophilias Flame haemorrhages, leaking veins. Arteries are INTACT
68
Branch retinal vein occlusion Tx
Laser photocoagulation Minimally invasive destroy/seal leaking blood vessels in retina (esp helpful if neovascularisation - can destroy)
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Causes of intravitreal haemorrhage
Retinal vein (branch/central) occlusion, Diabetic retinopathy, juxtafoveal telangiectasia, Microaneurysm/Macroaneurysm
70
Central retinal vein occlusion - Presentation (symptoms) - Opthalmoscopy (signs) - Prognosis
Mild/Severe loss of vision Marcus-Gunn pupil, Rubeosis (neovascularisation of the iris) Flame haemorrhages, Swollen optic disc, dilated/tortuous veins, blot haemorrhages, macular oedema 1/3 progress to retinal ischaemia
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Rubeosis def + causes
Neovascularisation on iris Diabetic retinopathy, CRVO, ocular ischaemia, retinal detachment Immediate AGGRESSIVE PRP (panretinal photocoagulation) +/- vitrectomy
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Anterior ischaemic optic neuropathy - Assoc - Presentation - Investigations - Fundoscopy - Treatment
GCA Sudden onset profound loss of vision ± Marcus-Gunn ESR, CRP, FBC (may want biopsy of temporal artery if GCA suspected as cause) Pale, swollen optic disc High dose steroids
73
Optic neuritis: - Assoc - Ophthalmoscopy - Recovery
Multiple sclerosis May appear normal Swollen, hyperaemic optic nerve (excess blood vessels) Spontaneous 6-8 weeks recovery (Steroid Tx may speed recovery)
74
Retinal detachment - pathophys - cause - presentation - treatment
Potential space between photoreceptors and retinal epithelium fills with fluid causing detachment Normally due to retinal tear. Flashes, Floaters, field loss Requires surgery to stop complete detachment
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Causes of retinopathy
HTN DM
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HTN retinopathy on ophthalmoscopy (Think what high BP will do)
Microinfarct (cotton wool spots) Arteriovenous nipping (vein disappears under artery) Flame/blot haemorrhage Microaneurysms Exudate Papilloedema (disc swelling)
77
Malignant HTN retinopathy
Microinfarct Tortuous veins Hyperaemic, swollen disc Elsching's spots (choroidal infarct) Macular exudate star
78
Accelerated/malignant HTN | - Causes
Exacerbated essential HTN Renal artery stenosis Phaeo, Cushing's, Conns
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Accelerated/malignant HTN - Causes of poor vision - Treatment complications
Acute optic nerve damage Macular oedema Retinal artery closure Choroidal detachment dropping BP too fast = ischaemic neuropathy + blindness
80
Flame Vs Blot haemorrhages
Haemorrhages are flame or blot shaped depending on depth in retina
81
Diabetic retinopathy - def - pathology
The retinal consequences of microvascular leaked and occlusion hyperglycaemia = inc viscosity of blood, loss of antithrombogenic endothelium = ischaemia/thrombus Pericyte loss/damage by hyperglycaemia = capillary leakage Ischaemia = inc VEGF promoting novasc, inc capillary permeability (Proliferative Diabetic retinopathy = sight threatening)
82
Diabetic retinopathy RFs
``` Poor glycemic control HTN Carotid stenosis Pregnancy Renal disease Anaemia ```
83
Diabetic retinopathy - symptoms - signs
Dark blots in vision (moderate disease) Blurred vision Floaters Vision loss Microaneurysms (seen in mild) Cotton wool spots, lipid exudates (moderate) Retinal haemorrhages (flame/dot/blot) Proliferative DR: Neovascularisation of retina/optic disc.
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Proliferative Diabetic retinopathy pathophys
Neovascularisation of retina or optic disc. New vessel fragile and prone to haemorrhage -> sudden vision loss Inc in fibrosis -> retinal detachment vision loss
85
What causes cotton wool spots
Poor perfusion/ischaemia
86
How is severity rate in DR
Number of quadrants affected Is there intra-retinal bleeding (none in mild - just micro aneurysms)
87
HTN retinopathy | - Triad
1) High BP 2) Visual disturbance 3) optic disc swelling/piplloedema
88
Diabetic retinopathy Tx
- Anti-VEGF (ranibizumab_ - Macular laser therapy (burns/reduces leaking BV under the macula) - Pan-retinal Photocoagulation therapy (controlled destruction of retina)
89
Screening in Diabetic retinopathy
Onset over 30 -screen 5 yearly | Onset under 30 screen annually
90
Red eye Red flag
Impaired vision Pain/Photophobia Lack of ocular discharge
91
Red eye causes over view:
Inflammation: - sclera: scleritis - intraocular: uveitis Intraocular infection: Endopthalmitis Raised IOP: Acute Glaucoma
92
Blephritis - Pres - Signs - Tx
Gritty, irritable eyes Watery discharge Foreign body sensation eyelid Loss of eyelashes, poor tear film, notched upper lid, ingrowing eyelash Lubrincants (poor tear film), lid hygiene and topical Abx if needed
93
Stye Vs Chalazion Tx
Granuloma of Meibomian glands (hard non-tender) Infected lash follicle = Stye (red, tender) Hot spoon bathing
94
Herpes Zoster (shingles) Opthalmaticus - Pathophys - Signs - Tx
Opthalmic division of trigeminal. If tip of nose affected normally so is eye (nasocilliary nerve) Severe corral inflammation, clouding and thinning Oral&Topical Acyclovir
95
What can cause Conjuctivitis?
Infection: Viral, Bacterial. Allergy Chemical irritation (pH imbalance)
96
Symptoms of Conjuctivitis
Red eye, swollen lid. Discharge - Watery: viral, allergic - Purulent: bacterial
97
Conjuctivitis - Viral cause - Bacterial cause - Neonatal potential cause - Allergic causes
Adenovirus commonly Staph, Strep Chlamydial (risk chlamydial pneumonitis) Topical NSAID/Steroids, Eye drops
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Treatment of Bacterial Conjuctivitis
Chloramphenicol eye drops Fusidic acid
99
Chlamydia Conjuctivitis - Complication - Tx
Corneal scarring - blindness Neonates - birth Adults - unwashed hands Systemic erythromycin
100
Opthalmia neonatorum: - Def - Causes
Defined as conjunctivitis in first 3 weeks of life (from birth canal) Chlamydia Gonorrhoea S-Aureus Herpes simplex
101
Chronic conjuncatavitis Assoc with? Risk of? Tx?
Atopy Corneal ulceration Topical steroids
102
Corneal disorders
Trauma Infective (Viral, Bacterial) Allergic
103
Corneal infection (Keratitis) - Viral cause + signs + tx - Bacterial cause and signs + tx
Herpes simplex, foreign body sensation, watery discharge, Topical acyclovir Staph/Pseudomonas, Red eye, Loss of vision, hazy cornea, Specialist Tx with intense ABx
104
What makes up the Uvea?
Iris Ciliary body Choroid
105
Anterior Uveitis: Assoc diseases
Seroneg (HLAB27) arthropathies - IBD - Psoriatic - Ankylosing Spondylitis Sarcoidosis, Syphilis, Behcet's (vasculitis)
106
Anterior Uveitis - Pres - clinical signs - What should be checked for
Acute & Unilateral Pain Red eye Photophobia Small pupil Normal/Decreased acuity Intense redness of globe Systemic dises: Joint, Chest (sarcoid), skin disease symptoms
107
Episcleritis: - where is this - pres - Tx
Vascular layer between sclera and conjunctiva Irritation/localised redness, no discharge/LOV NSAIDs helpful
108
Scleritis - Assoc - Pres
Rare and serious assoc with vasculitis & RA (thinning of sclera -> blue) Very painful Assoc with LOV
109
Acute angle-closure glaucoma - Who - Sign - Pres
Often elderly, Female, Long-sighted Very high IOP Unilateral, Painful, Red eye, Profuse LOV, Photophobia Nausea + vomiting
110
Normal Aqueous flow
Aq prod n ciliary body and flows between lens/iris through pupil into anterior chamber Leaves eye at angle to canal of Schlemm through trabecular meshwork
111
Acute angle-closure glaucoma mechanism
If pupil is dilated (e.g. dark room) Iris is pushed against the cornea and angle closes Rapid build up of pressure In long sighted, the lens shape pre-desposes to Acute angle-closure glaucoma (impairs Aq flow out of pupil)
112
Acute angle-closure glaucoma symptoms
Very red eye Corneal oedema Mid-dilated pupil Poor vision
113
``` Very red eye Corneal oedema Mid-dilated pupil Poor vision investigations ```
Gonioscopy (examination anterior angle) - trabecular meshwork not visible Slit-lamp - shallow anterior chamber, signs of glaucoma (large cup + nerve fibre loss)
114
Acute angle-closure glaucoma
1) lower pressure: Topical carbonic anhydrase inhibitors (acteazolamide)/Beta-blockers (Timolol) 2) Constrict pupil: colinergic agonists - Pilocarpine 3) Prevent recur: laser surgery to provide bypass
115
Discharge Ddx: - Watery eye - Purulent/mucus - Bloody
Inc lacrimation (foreign body in cornea), blocked tear duct Infection, allergy Severe infection, Tumour
116
Severe pain Ddx
Acute glaucoma Scleritis May also be seen in migraine, cluster headache
117
Vision loss Ddx (always serious) ``` Transient Profoud Rapid Slow Central Peripheral Loss colour Bilateral ```
``` Transient: Retinal emoli (Amourosis fugax) ``` Profound: GCA Rapid: Vascular (haemorrhage), Retinal detachment Slow: Dry macular degeneration Central: Optic nerve disease (neuritis in MS), DR Peripheral: Glaucoma, CVD Loss of colour: Optic neuritis Bilateral: Glaucoma
118
What serious eye diseases are asymptomatic in early stages
Chronic glaucoma Diabetic retinopathy HTN Papilloedema
119
What controls pupil size (muscle, ANS)
Constrict: - Sphincter pupillae muscle - CN3 - parasympathetic tone controls size Dilate: - Dilator pupillae - sympathetic nNS
120
Small pupil (Miosis) causes
Opiates, pontine haemorrhage, topical pilocarpine (pressure - glaucoma)
121
Mydriasis (dilated pupils) causes
Sympathomimetics (amphetamine, cocaine), anticholinergics, topical mydriatics
122
What is Horner's triad Causes
Miosis (constriction), Anhidrosis, partial ptosis Brainstem: stroke, carotid dissection Pancoast's tumours
123
What is seen in CNIII palsy Causes
Large pupil Ptosis Down and out eye Aneurysm to posterior communicating artery, uncle herniation post truma - send for neurosurgical review
124
Eye + Pupil in acute glaucoma
Bilateral large pupils and red eyes
125
Pupil in anterior uveitis
small in affected eye and red eye pupil can become unreactive and stuck to lens
126
Pupil 3 reflexes
Light: constrict/miosis Dark: dilate/mydriasis Near: Miosis, accommodation (ciliary focusing of lens)
127
Normal light response R optic nerve problem (afferent: retina -> brain)
Shine light into R. Both pupils constrict. R by direct. L by consensual Neither pupil responds when affected eye stimulated. Both pupils respond when light shone into L.
128
Marcus-Gunn pupil What is it? Underlying cause?
Relative afferent pupillary defect Swinging flashlight test. When shone in normal eye both will constrict (efferent pathways fine), when shone in affected eye (afferent lesion) there is dilation Partial injury to one optic nerve caused by large retinal lesions (detachment, central artery/vein occlusion optic neuritis, advanced glaucoma
129
Causes of central scotoma
Macular disease Optic neuritis Optic nerve ischaemia (GCA - part of optic nerve loses blood supply
130
Visual field loss in glaucoma
1) nasal and peripheral | 2) tunnel vision as superior and inferior defects join
131
Chiasmal compression visual field
Bitemporal hemianopia Pituitary - from below = upper field affected more Craniopharyngioma - compress from above = lower quadrantanopia
132
PITS
Parietal lesion = inferior quadrantanopia Temporal lesion = superior quadrantanopia
133
Horizontal conjugation How is this achieved What can cause intranuclear ophthalmoplegia
Communication between CNIII and CNVI means allows confluent horizontal gaze Via medial longitudinal fasicululus (jerky nystagmus if damaged)
134
Retinitis pigmentosa: What is it? Pres Onset Management
Hereditory, progressive dystrophy of photoreceptors in retina Ring scotoma, night vision problems. central vision is spared until late Onset 10-30yrs Manage to slow progress - refer to Opthal - DVLA inform - Acetazolomide (oral carbonic anhydrase inhibition's) + Beta Carotene
135
Dry eyes: | Causes
Aging Medication (diuretics, antidep, antihist, beta blockers) Systemic illness (RA, SLE, Sjogren’s - hyposecretive) Increased evaporation (low humidity, low blink rate, allergic conjunctivitis)
136
Treatment of dry eyes
Artificial tears
137
When to inform DVLA
Decreased acuity 1st unprovoked seizure (6M), Serious head injury (1M) TIA (3M), ACS/CABG 1M
138
Causes of sudden painless vision loss: flashes of light or floaters sudden visual loss, dark spots, Cheese and Tomato Pizza look afferent pupillary defect, 'cherry red' spot on a pale retina severe retinal haemorrhages are usually seen on fundoscopy
retinal detachment vitreal haemorrhage central retinal vein occlusion central retinal artery occlusion Other causes: Ischemic optic neuritis (atherosclerosis, GCA),
139
Open angle glaucoma Vs Closed angle Glaucoma
In open angle the iris is clear of the trabecular meshwork, in closed angle it is over the meshwork (e.g. when pupil is dilated)
140
Anterior Uveitis - Onset - what is felt - visual efects - pupil
acute onset pain blurred vision and photophobia small, fixed oval pupil, ciliary flush
141
Sudden Red painful eye, Dilated pupil What is likely diagnosis
Acute angle closure glaucoma
142
What is Pilocarpine and what are SE
Miotic (pupil constrictor) Constricted pupil, headache and blurred vision
143
What is Prostitutes pupil?
Argyll Roberston Neurosyphilis giving a constricted pupil (non-reactive to light) Also seen in Diabetic neuropathy