Organisation of Heredity materials Flashcards
(30 cards)
F. Miescher found the nucleic acids in the
human white blood cells in what year?
1869
Russian biochemist Phoebus Levene
investigated the Structure of nucleic acids in what year
1919
A nucleotide consists of three parts namely
Phosphate group
Deoxyribose Sugar
Nitrogenous waste
The bond between the phosphate group and Deoxyribose sugar is?
Phosphodiester bond
The bond between the deoxyribose sugar and nitrogenous waste is called?
Glycosidic bond
The structural levels of DNA molecule organisation are?
single strand[ nucleotides connected by phosphodiester bonds], double strand[ nucleotides connected by hydrogen bonds.] and double helix.
The DNA was made of 2 long stands of
nucleotides arranged in a specific
way called the?
Complementary rule.
Who noted the nucleotide composition of a DNA molecule.
Erwin Chargaff[ 1950]
who discovered the relationship in the nitrogenous wastes?
Erwin Chargaff
What did Astbury, Wilkin and Franklin suggest in the 1950’s?
The helix configuration for a DNA molecule.
Who proposed the double Helix structure for a DNA molecule?
James Watson and Francis Crick (1953
Who took an X-ray of the DNA molecule?
Dr Rosalind Franklin
Distance between to
nucleotides is
0.34 nm
Topoisomerase -
- unwinds DNA
Helicase
- breaks H-bonds
Single-stranded DNA-binding (SSB) proteins-
stable the free single-stranded DNA regions
RNA primase
catalyzes the polymerization of RNA building
blocks (A, U, G, C) into the primer;
DNA polymerase
- synthesizes of a new DNA molecule
(in 5’ to 3’ direction);
DNA ligase
catalyzes the linkage of Okazaki fragments;
Replicon
a region of DNA or RNA, that replicates
from a single origin of replication
We call Nucleic acids hereditary materials because
they contain information about the genes.
Nucleic acids are polymers made up
monomers
The diameter of a double helix is approximately;
2.0-2.2nm
Each turn of the double helix covers a distance of?
3.4nm
