organs and cells of immune system

Question 1

what happens in the primary lymphoid organs?

Answer 1

cells of immune system develop ( production and maturation)

Question 2

what are the primary lymph organs?

Answer 2

bone marrow and thymus

Question 3

what happens in the secondary lymphoid organs?

Answer 3

cells of immune system function/interact with antigens

Question 4

what are the secondary lymph organs?

Answer 4

lymph nodes 
spleen
tonsils
adenoid
RE system

Question 5

how are secondary and primary connected?

Answer 5

blood and lymphatic vessels

Question 6

where is bone marrow found?

Answer 6

medullary cavity of long bone

Question 7

hematopoietic stem cells aka

Answer 7

CD34+ cells

Question 8

where are HP stem cells found and what do they give rise to?

Answer 8

bone marrow

cells of immune system and blood cells

Question 9

what dictate what cell is formed from HP stem cells?

Answer 9

cytokines and growth factors

Question 10

when HP cell becomes myeloid stem cell what can it give rise to?

Answer 10

macrophages/monocytes
granulocytes
eosoniphil
RBC
platelets

Question 11

when HP cell becomes lymphoid stem cell what can it give rise to?

Answer 11

T and B cells

NK cells

Question 12

what is thymus derived from?

Answer 12

endoderm = 3rd pharyngeal pouch
ectoderm = 3rd brachial cleft
mesenchymal element

Question 13

where is thymus located?

Answer 13

anterior mediastinum

Question 14

what connects 2 lobes of thymus?

Answer 14

isthmus

Question 15

what occurs in thymus?

Answer 15

T cell maturation and differentiation (positive and negative selection)

Question 16

positive selection

Answer 16

T cell can bind to mhc class I / ii with at least weak affinity

Question 17

negative selection

Answer 17

if T cell bind to / recognize self –> apoptosis

Question 18

if there’s an issue with thymus what’s affected?

Answer 18

t cells

Question 19

what surrounds lymph node?

Answer 19

fibrous capsule

Question 20

what color is spleen and where is it located?

Answer 20

left upper quadrant of abdomen

brown

Question 21

what’s the function of the spleen?

Answer 21

RBC metabolism and blood borne infections

Question 22

what are the cells if the innate IS?

Answer 22

pmns

monocytes/MQs

Question 23

what are the cells of the specific / adaptive IS?

Answer 23

lymphocytes ( T,B cells)

Question 24

PMNs are

Answer 24

the Phils
baso
eosino
neutro

Question 25

when are neutrophils present?

Answer 25

bacterial infections

Question 26

when are eosinophils present?

Answer 26

parasitic / allergic run

Question 27

when are basophils present?

Answer 27

mast cells in tissue stimulated by allergens

Question 28

pmns aka

Answer 28

polymorphonuclear leukocytes

Question 29

B cell receptors

Answer 29

IgD IgM

Question 30

B cell effectors

Answer 30

plasma cell ( makes IgM IgG IgA)

Question 31

B cells recognize

Answer 31

``` protein/polysac antigens extracell antigens (no MHC) ```

Question 32

B cells

Answer 32

present antigens to t cells

Question 33

immature B cell has ___ and mature B cell has ___

Answer 33

CD19 | CD20

Question 34

T cell receptors

Answer 34

alpha beta | gamma delta

Question 35

T cells are ..

Answer 35

cd4+ or cd8+

Question 36

T helpers

Answer 36

``` cd4+ recognize mhc class ii ```

Question 37

t cytotoxic

Answer 37

``` cd8+ recognize mhc class i ```

Question 38

all T cells have .

Answer 38

cd3

Question 39

T cells can recognize only

Answer 39

protein

Question 40

T cell effectors

Answer 40

cytokines : Th1 and Th2