Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Microbiology 2nd Sem Midterm > Orthomyxovirus > Flashcards

Orthomyxovirus Flashcards

(73 cards)

Start Studying
1
Q

Epidemics

Human virus

A

Influenza B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Mild respiratory tract infection

A

Influenza C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Morphology

A

Segmented
SS genome
Helical nucleocapsid
Lipoprotein envelope

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Morphology 2

A

Envelope contain 2 spikes
Hemagglutinin
Neuramidase
Internal antigens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Morphology 3

A 
HA- hemagglutinin
NA- neuramidase
Helical nucleocapsid
Lipid bilayer membrane
Polymerase (3proteins)
M1 protein
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Influenza

Commonly called

A

The flu

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Influenza

Incubation period

A

1-4 days average of 2 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Influenza

Adult infectious

A

Day before symptom begins till 5days after onset

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Influenza

Children infectious

A

> 10 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Influenza

Young children infectious

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Influenza

Immunocompromised persons can shed virus for

A

Weeks or months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Influenza infection has also been associated with

A 
Encephalopathy
Transverse myelitis
Reye syndrome
Myositis
Myocarditis
Pericarditis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Population at risk for complications, hospitalization and deaths

A

> 65 years old
Young children
Cardio, metabolic and pulmonary problems
Receiving long term ASA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

In colder countries flu is largely seen during

A

Colder months and they vaccinate prior to this season (October)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

In tropical countries flu is seen

A

All year round

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Type of influenza that may cause epidemic

A

A and B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Type of influenza that may cause pandemics

A

A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Getting flu shot can prevent illness from

A

A and B

But not for C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Cause mild respiratory illness

Not thought to cause epidemics

A

Influenza type C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Influenza

Genome

A

Segmented

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Influenza virus divided into subtypes based on

A

HA and N proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Nomenclature based on

A

Site of origin
Isolate number
Year of isolation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Small changes in the virus that happen continually ( Aand B)

A

Antigenic drift

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Abrupt, major change in the influenza A viruses, resulting in new H and or new H and N proteins that infect the humans (A only)

A

Antigenic shift

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Current subtypes of influenza A viruses found in people are
A(H1N1) | A (H3N2)
26
Not divided into subtypes
Influenza B virus
27
Included in each years influenza vaccine
A(H1N1 A(H3N2) Influenza B
28
Current flu pandemic: novel A (H1N1) Quadruple reassortant:
2 NA bird flu genes 1 swine flu Human flu
29
Current flu pandemic: novel A (H1N1) Characteristics
Lower respi More contagious More common than seasonal flu
30
Current flu pandemic: novel A (H1N1) Resistant to
Amantadine | Rimantadine
31
Avian influenza Caused by how many subtypes of influenza A virus,
15
32
Avian influenza Extremely contagious in
Birds
33
Avian influenza Almost 100% in a few days
Rapidly fatal | High mortality
34
Avian influenza Most recent
H5N1
35
Domestic ducks
H7N3 virus
36
Wild birds
H7N9
37
Domestic poultry
Multiple H 9N2
38
Treatment for influenza Adamantanes
Amantadine | Rimantadine
39
Treatment for influenza Neuraminidase inhibitors
Zanamivir | Oseltamivir
40
Treatment for influenza Antiviral treatment lasts for
5 days and must be started within
41
Inactivated/split type of vaccine
Trivalent or quadrivalent
42
Vaccines
Live attenuated vaccine Cold adapted Intranasal
43
Vaccine dose by age group 6-35months
.25ml 1or2 dose IM
44
Vaccine dose by age group 3-8years
.5ml 1or2 doses IM
45
Vaccine dose by age group >9 years
.5 ml 1 dose IM
46
Properties of orthomyxovirus and paramyxovirus
Nasa powerpoint, table.
47
Orthomyxovirus
Negative Single stranded RNA
48
A and B segments
8
49
C segments
7
50
Enveloped with glycoprotein spikes
H- hemagglutinin | N- neuraminidase
51
Surface antigen Binds with the host cell receptor
H Ag
52
Surface antigen Can neutralize the virus
H antibodies
53
Surface antigen Can agglutinate RBC of various animals
H Ag
54
Surface antigen Receptor destroying the enzyme Promotes spread of the virus to the lower part of the respiratory tract
N Ag
55
Nomenclature
Influenza Ao (HoN1)
56
Major change | Undergoes genetic re-assortment due to the segmented nature of the genome
Antigenic shift
57
Antigenic shift Responsible for
Pandemics and epidemics
58
Antigenic shift Cyclic after every
10 years
59
A minor change | Results from a change in the amino acid sequence of H Ag but H remains basically the same protein.
Antigenic drift
60
Influenza A virus involed in Pandemics and epidemics
Memorize mo, nasa manual
61
Emerging and re emerging influenza A viruses
Memorize mo din nasa manual
62
Complication
Primary influenza pneumonia Secondary bacteria pneumonia Reye's syndrome (B) Guillain-Barré syndrome
63
Diagnosis Isolation
Monkey kidney tissue culture | Madin Darby canine kidney
64
Diagnosis Isolation Does not produce
Cytophatic effect
65
Diagnosis Presence of the virus detected by RBC will adhere to the tissue culture
Hemadsorption technique
66
Diagnosis Virus agglutinates RBC
Hemagglutination test
67
Diagnosis Respiratory secretions
Fluorescent Ab technique
68
Diagnosis CF Ab and HI Ab
Serology
69
Effective against A
Amantadine Rimantdine Target M2 protein Effective when given in early stage
70
Effective against A and B
Oswltamivir | Zanamivir
71
Inactivated virus vaccine
Vaccine
72
Nasal spray
Love attenuated | Cold adapted
73
Pandemics and epidemics humans and animals
Influenza A

Microbiology 2nd Sem Midterm (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions