Parvo Virus, Papilloma And Polyoma Virus Flashcards by joseph dizon

Parvovirus

Characteristics

Icosahedral capsid
SS DNA
Naked
Non envelopd

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Parvovirus

Major capsid protein

Non structural protein requires for replication

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Parvovirus

Replicates only during the

Stationary phase

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Parvovirus

Requires helper virus

Adenovirus

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Parvovirus

Causes infection in humans

B19 virus

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Parvovirus

Classification

Parvoviridae

2. Desoviridae

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Parvovirus

Parvoviridae

Erthythrovirus
Bocavirus
Dependovirus

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Parvovirus

Erthythrovirus

Parvovirus B19 type 1
Strain k71 type 2
Strain v9 type 3

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Parvovirus

defective virus that is an adeno-associated virus

Dependovirus

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Parvovirus

Infect the insects

Desoviridae

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B19

Cellular receptor

Blood group B antigen

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B19

Erythroblastosis in the bone marrow

Aplastic anemia

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B19

Endothelial cells on the blood vessels

Rash

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Parvovirus B19

Mode of transmission

Respiratory and oral secretions 
Blood transfusion 
Transplacental
Human ar only natural reservoir
No virus excretion in the urine

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Parvovirus B19

Targets the

Immature cells in the erythroid lineage

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Parvovirus B19

Major site of replication are in the

Bone marrow
Fetal liver
Some blood vessels

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Parvovirus B19

Replication can cause

Death

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Parvovirus B19

Syndromes involved

Erythema infectiosum/ 5th disease
Transient aplastic crisis
Pure red cell aplasia
Hydrops fetalis

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Erythema infectiosum/ 5th disease

Including

Rosella rubella
Rubeolla
Varicella

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Erythema infectiosum/ 5th disease

Occurs in

Early school age

Adults

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Erythema infectiosum/ 5th disease

1-2 weeks

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Erythema infectiosum/ 5th disease

Most probable site of viral shedding

Pharynx

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Erythema infectiosum/ 5th disease

Contagious stage

Lytic stage

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Erythema infectiosum/ 5th disease

Highest titter

Respiratory

Oral secretions

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Erythema infectiosum/ 5th disease Enters through the respiratory tract then spreads to _________ stopping of RBC production due to viral killing of erythroid series

Bone marrow - adult | Fetal liver - children

Erythema infectiosum/ 5th disease Viremia

1 week after infection

Erythema infectiosum/ 5th disease Pathogenesis

``` Respiratory tract Bone marrow Stop RBC Viremia Contagious stage Persist 5 days Present in nasal washes and gargle specimen ```

Erythema infectiosum/ 5th disease | 2nd stage of illness

``` Immunologic stage Appearance of antibodies Resolution of disease Erythematous Rash and arthralgia ```

Appearance of B 19 virus specific

Anti IgM

Erythema infectiosum/ 5th disease | Generalized erythematous rash most prominent in the face

Cutaneous rash or slapped cheek

Erythema infectiosum/ 5th disease Arthralgia

Hands and knees Adult

Transient aplastic crisis Occur in patient with

Chronic hemolytic anemia | After bone marrow transplantation

Transient aplastic crisis Only in patients with hemolytic anemia

Abrupt cessation of RBC synthesis

Persistent infection and chronic anemia | Immunocompromised patient

Pure red cell aphasia

Fetus is affected | Result of severe fetal anemia, especially in 2nd trimester

Hydrops fetalis Fetal death before 20th week of pregnancy

Hydrops fetalis

No congenital abnormalities because the blood is the one affected

Prevalent in children with acute wheezing | Often found in mixed infections with other viruses

Human Bocavirus respiratory infection

Human Bocavirus respiratory infection Pathogenesis

Unknown

Human Bocavirus respiratory infection MOT

Respiratory route | Also detect in stool and serum samples

Parvovirus diagnosis Most sensitive, in situ hybridization of fixed tissues

PCR

Parvovirus diagnosis Serology

B19 IgM antibody Present 2-3 months after infection

Parvovirus treatment 5th disease

Symptomatic treatment

Parvovirus treatment Transient aplastic crisis

Symptomatic | Blood transfusion

Parvovirus treatment For immunocompromised and those with anemia

Immunoglobulin preparations containing antibodies

Parvovirus treatment Vaccine

No vaccine available

Papovavirus Old classification and does not exist 2 families

Papilloma virus | Polyomavirus

Capable of causing lytic, chronic, latent, and transforming infection depending on host cell

Papovavirus

Papovavirus | Morphology

Small Icosahedral capsid Non enveloped DS DNA

Papovavirus Encode proteins that promote

Cell growth Lytic viral replications Permissive cell type Oncogenically transformed non permissive cell type

Papovavirus Stimulate cell growth which facilitate replication of the viral genome Codes for no structural protein

Early Genes ( E1-E7)

Papovavirus example of early gene

BT1 BT2 BT3

Papovavirus Viral attachment portein Codes for structural protein

Late genes (L1 and L2)

Human Papilloma virus

Former member of the papoviridae

Human Papilloma virus Characteristics

Double stranded circular CAN Icosahedral Naked

Human Papilloma virus Oncogenic

E6 and E7 oncoproteins

Human Papilloma virus Do not grow in

Cell cultures

Human Papilloma virus Capsomeres form

Regular pointed star shaped head

Human Papilloma virus Have defined tissue tropism

Epithelial cells of skin and mucous membrane

Human Papilloma virus Result mutation and stimulation of nuclear factors to chromosomal aberration

E7 protein to p105RB (retinoblastoma)

Human Papilloma virus Encode early 7 genes and late 2 genes

E6 protein to p53

Human Papilloma virus 100 types of papilloma virus that are grouped into

1-16

Human Papilloma virus Lytic infections

Permissive cells

Human Papilloma virus Abortive, latent, persistent or immortalizing infections that can transform the cell into cancer

Non-permissive cells

Human Papilloma virus Important characteristics

Stimulate DNA synthesis Tissue tropism Significant cause of human cancer Viral oncoproteins

Human Papilloma virus Classifications

``` Alpha Beta Gamma Mupa Napa ```

Human Papilloma virus HPV type of plantar warts

1 Benign

Human Papilloma virus Type of common skin warts

2,4,27,57 Benign

Human Papilloma virus Type of HPV cutaneous lesions

3,10,28,29,60,76,78 Low

Human Papilloma virus Epidermodysplasia verruciformis

``` 5 8 9 12 17 20 36 47 ``` Mostly benign

Human Papilloma virus Hand warts of butchers

7 Low

Human Papilloma virus Anogenital warts

6,11,40,42-44,54,61,70,72,81 Low

Human Papilloma virus Infect and replicate in the

``` Squamous epithelium (warts) Mucous membranes (papilloma virus) ```

Human Papilloma virus Enlarged keratinocytes with haloes around shrunken nuclei

Koilocytes

Human Papilloma virus Infection may regress spontaneously but

Recurrence is common

Human Papilloma virus Important in the resolution of and control of the infection

Innate immunity and CMI

Human Papilloma virus MOT

Direct contact- due to shedding Minor skin abrasions Sexual contact - anogenital warts

Human Papilloma virus Mole and warts

Mole- smooth surfaces | Warts- rough

Human Papilloma virus Skin warts

1-4

Human Papilloma virus Laryngeal papilloma

6 and 11

Human Papilloma virus Anogenital warts

6&11 Condylomata acuminata

Human Papilloma virus Cervical, orophanyngeal and penile Ca

Worst type of warts | 16 and 18

Human Papilloma virus It takes 3-4 months before a wart can develop Once you have a warts, faster spread

Epidermodysplasia verruciformis

Human Papilloma virus Usually in the face and body

Flat warts

Human Papilloma virus Domed shape warts Hands and feet

Common warts

Human Papilloma virus | Skin tags

Cutaneous lesion

Human Papilloma virus ``` Usually malignant Sun exposure 30-40 Mixed type HPV Very rare autosomal recessive ```

Epidermidis plasma verruciformis

Human Papilloma virus Laboratory diagnosis

Cytology DNA molecular probe PCR Southern blot

Human Papilloma virus Treatment Used for common warts

Surgical excision

Human Papilloma virus Treatment For flat warts

Application of caustic agents Electro cautery Cryosurgery

Human Papilloma virus Treatment Drugs

Imiquimod Topical idoxuridine Systemic or intralesional alpha interferon Cidofovir

Human Papilloma virus Prevention From HPV 6,11,16 and 18

Quadrivalent vaccine

Human Papilloma virus Prevention From type 16 and 18 for high risk patient

Bivalent

Human Papilloma virus Vaccine given as early ____ before they become sexually active

Yung polyoma virus, wala pang BS

Kpag may time pa gawan, kung wala na, dun mo na lang aralin,

Smallest and simplest of all DNA viruses

Parvovirus

Parvo Virus, Papilloma And Polyoma Virus Flashcards

(95 cards)