Ossification Flashcards Preview

IMS: Histology > Ossification > Flashcards

Flashcards in Ossification Deck (34):
1

What are the 2 types of ossification?

- intramembranous
- endochondral

2

What bones are formed by intramembranous ossification?

- clavicle
- most cranial bones

3

What is the 1st type of bone cell in IO?

Mesenchymal cells

4

In the 1st step of IO, what do mesenchymal cells do?

Cluster together

5

1st Step of IO: What do mesenchymal cells differentiate into?

Osteoblasts

6

1st Step of IO: What is the term for the site of cluster?

Ossification centre

7

1st Step of IO: What do osteoblasts secrete?

Extracellular matrix

8

2nd Step of IO: What do osteoblasts differentiate into?

Osteocytes

9

2nd Step of IO: What process occurs which involves the hardening of the extracellular matrix?

Calcification

10

2nd Step of IO: What mineral is deposited?

Calcium

11

3rd Step of IO: What T is formed?

Trabeculae

12

3rd Step of IO: Trabeculae fuse together to form what type of bone?

Spongy/cancellous bone

13

3rd Step of IO: Connective tissue associated with blood vessels in the trabeculae differentiates into ?

Red bone marrow

14

4th Step of IO: What is formed at the edge of the bone from mesenchyme?

Periosteum

15

What types of bone are formed using intramembranous ossification?

Flat

16

4th Step of IO: What type of bone tissue replaces the spongy bone, only at the surface?

Compact bone

17

4th Step of IO: What type of bone tissue remains in the middle of the bone?

Spongy bone

18

4th Step of IO: What type of bone cell is used to destroy and reform the bone?

Osteoclasts

19

Which types of bones are formed by Endochondral Ossification?

Long bones

20

1st Step of EO: What do mesenchymal cells differentiate into?

Chondroblasts

21

1st Step of EO: what do chondroblasts secrete?

cartilage extracellular matrix

22

1st Step of EO: What does the cartilage model mostly consist of?

Hyaline cartilage

23

2nd Step of EO: Once chondroblasts are deeply buried in the matrix, what are they called?

Chondrocytes

24

2nd Step of EO: How does growth of the cartilage model occur?

Cell division of chondrocytes

25

2nd Step of EO: What process occurs?

Calcification

26

2nd Step of EO: Why do some chondrocytes begin to die?

Nutrients cannot diffuse through the matrix

27

2nd Step of EO: What are the spaces called which are left due to the dead chondrocytes?

lacaunae

28

3rd Step of EO: What develops in the diaphysis of the bone?

Primary ossification centre

29

3rd Step of EO: What replaces most of the cartilage?

Bone tissue

30

4th Step of EO: What bone cells break down the bone to form the medullary cavity?

Osteoclasts

31

4th Step of EO: What is most of the wall of the diaphysis replaced with?

Compact bone

32

5th Step of EO: What develops in the epiphysis of the bone?

Secondary Ossification centre

33

6th Step of EO: What 2 things are formed:

- Epiphyseal plate
- Articular cartilage

34

6th Step of EO: What do the epiphyseal plate and articular cartilage both consist of?

Hyaline cartilage