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Flashcards in OSTEOARTHRITIS Deck (12)
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1
Q

OSTEOARTHRITIS INFO

A

at least 1/10 older adults fufer from symptomatic asteoarthritis

  • is the most prevealent chronic joint disease
  • involves degeneration of cartilage in joints, which can result in PAIN + DISABILITY
  • knees, hips, and hands are the most affected sites
2
Q

OSTEOARTHRITIS MANAGEMENT

A
  • patients hsould receive a COMBO of
    1) NONPHARMACOLOGIC tx
    2) PAHRMACOLOGIC tx
  • several pahrm therapies are useful for treating the pain associated with osteoarthritis
  • none of them prevnents progression of the disease
  • the choice of medication depends upon the
    1) SEVERITY of disease, and the
    2) presence/absence of LOCAL INFLAMMATORY CHANGES
3
Q

DRUGS FOR OSTEOARTHRITIS

A
  1. ACETAMINOPHEN
  2. NSAIDS
  3. DULOXETINE
  4. TRAMADOL
  5. OPIOIDS
  6. CAPSAICIN
  7. INTRAARTICULAR CORTICOIDS
4
Q

ACETAMINOPHEN

A

ACETAMINOPHEN = TYLENOL

  • is generally the FIRST LINE tx for the MILD-MODERATE OA pain WITHOUT signs/symptoms of inflammation
  • has no clinically significant anti-inflammatory activity and is less effective than full doses of NSAIDS (but has fewer side effects)
5
Q

NSAIDS

A
  • used
    1) if clinical response to acetaminophen is not satisfactory,
    2) clinical presentation of OA is INFLAMMATORY
  • nsaids can be used IN ADDITION to or in place of acetaminophen
6
Q

DICLOFENAC

A

NSAID

DICLOFENAC –> DI CLO(F)TH –> cloth –> helped to rub in the TOPICAL GEL used for sympatic OA

  • is available as a TOPICAL GEL or solution for LOCAL TREATMENT of OA
  • topical preps are useful in
    1) patients with SYMPTOMATIC DISEASE limited to a few sites or in
    2) patients at increased risk for Adverse Effects with systemic NSAIDS
7
Q

DULOXETINE

A

DULOX = DELUXE –> selective Serotonin + NE REUPTAKE INHIB –> DELUXE fancy drug that helps mask chronic MSK PAIN

  • selective serotonin and NE reuptake INHIBITOR
  • is approved for tx of CHRONIC MSK PAIN
8
Q

TRAMADOL

A

TRAM-A-DOL –> if a tram hit a doll, it would be moderate to moderatley severe OA

-approved for tx of MODERATE-MODERATELY SEVERE CHRONIC PAIN in adults

9
Q

OPIOIDS

Which ones used? When?

A
  • LAST RESORT for tx of INTRACTABLE OA PAIN
  • agents used inlcude HYDROCODONE, MORPHINE, OXYCODONE
10
Q

CAPSAICIN

A

GOES ON OUR kneeCAP

topical application reduces OA pain in some patients

  • it can cause severe skin burns and nerve damage at the site of application
  • the dried residue can cause COUGHING, SNEEZING, EYE IRRITATION
11
Q

INTRAARTICULAR CORTICOSTEROIDS

-which two are used?

A

BETA-TRI ONE

–> it’s a BETA test so might as well TRI it in ONE knee

-in patients with persistent symptoms, in one or a few affected joints, intraarticular glucocorticoid injections can be used

BETAMETHASONE + TRIAMCINOLONE are the glucocorticoids commonly used

12
Q
A