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Flashcards in OSTEOARTHRITIS Deck (12):
1

OSTEOARTHRITIS INFO

at least 1/10 older adults fufer from symptomatic asteoarthritis

-is the most prevealent chronic joint disease

-involves degeneration of cartilage in joints, which can result in PAIN + DISABILITY

-knees, hips, and hands are the most affected sites

2

OSTEOARTHRITIS MANAGEMENT

-patients hsould receive a COMBO of 

1) NONPHARMACOLOGIC tx

2) PAHRMACOLOGIC tx

-several pahrm therapies are useful for treating the pain associated with osteoarthritis

-none of them prevnents progression of the disease

-the choice of medication depends upon the

1) SEVERITY of disease, and the

2) presence/absence of LOCAL INFLAMMATORY CHANGES

3

DRUGS FOR OSTEOARTHRITIS

1. ACETAMINOPHEN

2. NSAIDS

3. DULOXETINE

4. TRAMADOL

5. OPIOIDS

6. CAPSAICIN

7. INTRAARTICULAR CORTICOIDS

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ACETAMINOPHEN

ACETAMINOPHEN = TYLENOL 

-is generally the FIRST LINE tx for the MILD-MODERATE OA pain WITHOUT signs/symptoms of inflammation

-has no clinically significant anti-inflammatory activity and is less effective than full doses of NSAIDS (but has fewer side effects) 

5

NSAIDS

-used

1) if clinical response to acetaminophen is not satisfactory, 

2) clinical presentation of OA is INFLAMMATORY

 

-nsaids can be used IN ADDITION to or in place of acetaminophen

6

DICLOFENAC

NSAID

DICLOFENAC --> DI CLO(F)TH --> cloth --> helped to rub in the TOPICAL GEL used for sympatic OA 

-is available as a TOPICAL GEL or solution for LOCAL TREATMENT of OA

-topical preps are useful in

1) patients with SYMPTOMATIC DISEASE limited to a few sites or in

2) patients at increased risk for Adverse Effects with systemic NSAIDS

7

DULOXETINE

DULOX = DELUXE --> selective Serotonin + NE REUPTAKE INHIB --> DELUXE fancy drug that helps mask chronic MSK PAIN

-selective serotonin and NE reuptake INHIBITOR

-is approved for tx of CHRONIC MSK PAIN

8

TRAMADOL

TRAM-A-DOL --> if a tram hit a doll, it would be moderate to moderatley severe OA

-approved for tx of MODERATE-MODERATELY SEVERE CHRONIC PAIN in adults 

9

OPIOIDS

Which ones used? When? 

-LAST RESORT for tx of INTRACTABLE OA PAIN 

-agents used inlcude HYDROCODONE, MORPHINE, OXYCODONE

10

CAPSAICIN

GOES ON OUR kneeCAP 

topical application reduces OA pain in some patients

-it can cause severe skin burns and nerve damage at the site of application 

-the dried residue can cause COUGHING, SNEEZING, EYE IRRITATION

11

INTRAARTICULAR CORTICOSTEROIDS

-which two are used? 

BETA-TRI ONE

--> it's a BETA test so might as well TRI it in ONE knee

-in patients with persistent symptoms, in one or a few affected joints, intraarticular glucocorticoid injections can be used

BETAMETHASONE + TRIAMCINOLONE are the glucocorticoids commonly used 

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