OSTEOMALACIA

Question 1

DEFINE

Answer 1

INADEQUATE MINERALISATION OF EXCESSIVE OSTEOID DUE TO INTERFERECE IN CALCIFICATION MECHANISM LEADING TO SOFTENING OF BONE

Question 2

ETIOLOGY

Answer 2

LACK OF EXPOSURE TO SUNLIGHT
DIETARY DEFICIENCY OF VIT D
UNDRNUTRITION DURING PREGNANCY
MALABSORPTION SYNDROME

Question 3

CLINICAL FEATURES

Answer 3

EARLY STAGE, NO MUCH SIGNS AND SYMPTOMS
LATER , BONE PAIN
MUSCLE WEAKNESS - TETANY- MAY MANIFEST AS CARPOPEDAL SPASM AND FACIA TWITCHING ) , WADDLING GAIT
SPONTANEOUS FRACTURE

Question 4

INVESTIGATION

Answer 4

RADIOLOGICAL
BONE BIOPSY
SEROLOGY

Question 5

RADIOLOGICAL

Answer 5

LOOSERS ZONES - FRACTURE LINE SURROUNDED BY SIGNS OF HEALING ( CALLUS)
TRIRADIATE PELVIS - IN FEMALE
PROTRUSIO ACETABULI
RAREFRACTION OF BONES
CODFISH SPINE
SPONTANEOUS FRACTURE

Question 6

BONE BIOPSY

Answer 6

FROM ILLIAC CREST - CONFIRMS DIAGNOSIS

Question 7

SEROLOGY

Answer 7

SERUM CALCIUM PHOSPHATE LOW
ALP AND PTH HIGH

Question 8

TREATMENT

Answer 8

VIT D DAILY AT MAINTAINANCE DOSE OF 400 TO 2000 IU
IN CASE OF MALABSORPTION - HIGHER DOSE UPTO 50 THOUSAND IU OR IM VIT D + CALCIUM
IN PTS WITH RENAL DISEASE - APHA CALCIDOL
UNDERLYING CAUSE TREATED
HIGH PROTEIN DIET