Other Stuff Flashcards
5HT2 agonist
LSD
5HT1A agonist
Buspirone
5HT1D agonist
Sumatriptan
SSRI
Fluoxetine
MAOI
Phenelzine
5HT2 antagonist
Cyproheptadine
5HT3 antagonist(s)
Ondansetron
Alosetron
1st generation H1 blockers
Diphenhydramine
Dimenhydrinate
Promethazine
Chlorpheniramine
2nd generation H1 blockers
Loratidine
Desloratidine
Ceterizine
Fexofenadine
H2 blockers
Cimetidine
Ranitidine
Famotidine
PGE1 analog(s)
Misoprostol
Aloprostadil
PGE2 analog
Dinoprostone
PGE1(2) analog
Epoprostenol
PGF2 analog
Carboprost
PGF2(alpha) analog
Bimatoprost
Eicosanoid function – Platelets
TXA2
PGI2
TXA2 - promotes platelet aggregation
PGI2 - inhibits platelet aggregation
Eicosanoid function – Repro and Parturition
PGI2
PGE2
PGF2
PGI2 - Relaxation of uterine tone
PGE2 - initiation and progression of labor (uterine contractility and cervical ripening)
PGF2 - uterine contractility during labor, primary dysmenorrhea
Eicosanoid function – CV & Vasculature
PGE2, PGI2, PGD2
TXA2, PGF2, PGD2 (pulmonary only)
PGE2, PGI2, PGD2 - vasodilators
TXA2, PGF2, PGD2 - vasoconstrictors
Eicosanoid function –Development
PGE2
PGE2 - maintains ductus arteriosus
Eicosanoid function – Pulmonary smooth muscle
PGEs, PGI2
TXA2, PGF2, PGD2, LTC4, LTD4
PGEs, PGI2 - Relaxation
TXA2, PGF2, PGD2, LTC4, LTD4 - Constriction
Eicosanoid function – Kidney
PGE2, PGI2
PGE2, PGI2 - Increase RBF due to vasodilation
Eicosanoid function –Gastrointestinal
PGE2, PGI2
PGE2
PGE2, PGI2 - inhibits gastric acid secretion, increase gastric mucosal blood flow
PGE2 - viscous mucus secretion, bicarbonate secretion, contraction of GI smooth muscle
Eicosanoid function -- Inflammation PGE2 PGE2, PGI2 LTC4, LTD4 LTB4
PGE2 - fever
PGE2, PGI2 - Pain, sensitize afferent nerve ending by lowering nociceptor threshold
LTC4, LTD4 - Vasoactive effects, increase vascular permeability
LTB4 - Neutrophil chemotaxis
