Ovarian Cancer Tumor Markers/Histology

Question 1

Papillary serous carcinoma

Answer 1

CA-125

Question 2

Clear cell carcinoma

Answer 2

CA-125
CA 19-9

Question 3

Dysgerminoma

Answer 3

LDH

Question 4

Yolk sac/Endodermal sinus tumor

Answer 4

AFP

Question 5

Choriocarcinoma

Answer 5

hCG

Question 6

Embryonal carcinoma

Answer 6

hCG + AFP

Question 7

Granulosa cell tumor

Answer 7

Inhibin (A > B)
*leads to excess E production

Question 8

Immature teratoma

Answer 8

AFP

Question 9

Thecoma

Answer 9

Estrogen

Question 10

Leydig cell tumor

Answer 10

Testosterone

Question 11

Endometrioid carcinoma

Answer 11

CA-125

Question 12

Mucinous ovarian tumor

Answer 12

CA 19-9
CEA

Question 13

Mature teratoma

Answer 13

CA-125
CA 19-9

Question 14

Mixed germ cell tumor

Answer 14

AFP
hCG

Question 15

Round, central area w/ surrounding Ca collections

Answer 15

Psammoma body

Question 16

Transluscent cytoplasm

Answer 16

Clear cell

Question 17

Bulbous nuclei that appear to protrude beyond the cytoplasmic limit of the cell

Answer 17

Hobnail cell

Question 18

Dense, abundant fibrous stroma w/ nests of transitional epithelium

Answer 18

Walthard nests

Question 19

Large, round nucleus w/ large mucin vacuole filling rest of cell

Answer 19

Signet cell

Question 20

Tumor w/ sheets of lymphocytes/germ cells w/ cytoplasmic glycogen w/ periodic acid-schiff stain

Answer 20

Dysgerminoma

Question 21

Central vessel/capillary lined by columnar cells (invaginated papillary structures)

Answer 21

Schillar-Duval bodies

Question 22

Tumor w/ malignant cyto & syncytiotrophoblast cells

Answer 22

Choriocarcinoma/Embryonal carcinoma

Question 23

Sheets of tumor cells w/ coffee-bean nuclei around an eosinophilic fluid space

Answer 23

Call-Exner bodies

Question 24

Tumor w/ immature neuroepithelium

Answer 24

Immature teratoma

Question 25

Tumor w/ lipid-laden stromal cells +/- luteinization

Answer 25

Thecoma

Question 26

Tumor w/ Reinke crystals

Answer 26

Leydig cell tumor

Question 27

Sertoli-Leydig cell tumor

Answer 27

Increased T:DHEAS ratio Thyroid storm

Question 28

Psammoma body

Answer 28

Ovarian papillary serous carcinoma

Question 29

Hobnail cells

Answer 29

Clear cell carcinoma

Question 30

Walthard nests

Answer 30

Brenner's tumor

Question 31

Signet cells

Answer 31

Krukenberg tumor

Question 32

Schillar-Duval bodies

Answer 32

Yolk sac/Endodermal sinus tumor

Question 33

Call-Exner bodies

Answer 33

Granulosa cell tumor

Question 34

Krukenberg tumors are MC assc w/ primary tumors of the...

Answer 34

GI (stomach 70%)

Question 35

Brenner's tumors, and other mucinous ovarian tumors, are MC assc w/ what other organ?

Answer 35

Appendix