ovarian hyperstimulation syndrome

Question 1

most common drug used to stimulate follicles

Answer 1

clomiphene citrate

Question 2

what levels of estradiol are considered high

Answer 2

> 3500 can lead to ovarian hyperstimulation syndrome

Question 3

what is the main factor that leads to vascular endothelial growth factor which then leads to ovarian hyperstimulation syndrome

Answer 3

HCG trigger

Question 4

mathur classification of ovarian hyperstimulation syndrome

Answer 4

mild - ovarian size <8cm , no ascites
moderate- 8-12 cm, ascites can be seen in ultrasound
severe->12cm , clinical ascitis
critical , critical ascitis(respiratory distress near death)

in severe ohss hematocrit >45
in criticalohss hematocrit >55

Question 5

management of ohss

Answer 5

• avoid pregnancy in severe and critical forms
• give oral fluids for mild and moderate forms
• remove fluids (tap ascites and effusion)
• iv fluids in severe and critical forms

Question 6

drug of choice in ovarian hyperstimulation syndrome

Answer 6

albumin(colloid) it’s a big molecule

Question 7

drug cabergoline

Answer 7

• its a dopamine agonist which inhibits VEGF(vascular endothelial growth factor) , indicated in ohss
• its given on HCG trigger day
• dose 0.5mg(8days)