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Flashcards in Ovarian Masses Deck (23):
1

Where anatomically are the ovaries and what are its attachments?

Occupy the ovarian fossa on the lateral pelvic wall overlying the ureter.

They are attached to:
-the broad ligament by the mesovarium
-the pelvic wall by the infundibulo pelvic ligament
-the uterus by the ovarian ligament

2

How are ovarian masses usually identified?

As a incidental finding on USS.

If they are very large and cause abdominal distension.

Acutely associated with accidents, rupture, haemorrhage, torsion.

3

In which group are epithelial tumours most common?

Most common in post menopausal women.

Can be both benign and malignant

4

What are the different types of epithelial tumours?

Serous cystadenoma or adenocarcinoma: most common malignant ovarian neoplasm. (usually unilocular)

Mucinous cystadenoma or adenocarcinoma: 10% malignant multloculated and unilateral.

Endometriod carcinoma: often malignant and associated with endometrial carcinoma.

Clear cell carcinoma: relatively rare, malignant with a very poor prognosis.

Brenner tumours: rare, small, benign and unilateral.

Note: malignant epithelial tumours are commonly referred to as ovarian Ca

5

Which group are germ cell tumours most common in?

Young premenopausal women.

6

What are the different types of germ cell tumours?

Teratoma/dermoid cyst:
Usually benign, most common in young premenopausal women 90%. Often asymptomatic but can rupture which is very painful. May contain fully differentiated tissues (hair, teeth).

Can be malignant very rarely.

Dysgerminoma: rare but still most common ovarian malignancy in younger women.

7

Where do sex chord tumours originate from?

Stroma of the gonad.

8

What are the different causes of sex chord tumours?

Granulosa cell tumours: usually malignant, but slow growing. Secrete oestroddiol and inhibin. Causes bleeding, endometrial hyperplasia and endometrial malignancy. Inhibin is used as the tumour marker.

Thecomas: Very rare, usually benign secrete oestrogen and androgens and present with PV bleeding.

Fibromas: Rare and benign. Can cause meig's syndrome: ascites, pleural effusion + small ovarian mass.

9

What are the non neoplastic causes of ovarian masses?

Functional cysts (most common enlargement of the ovaries in reproductive years)

Pathological:
-Endometriotic cysts aka chocolate cysts/endometriomas
-PCOS
-Theca lutein cysts: multiple ovarian cysts occur in conditions with increased HCG

10

What are the different types of functional cyst?

Follicular or lutein which are persistently enlarged follicles and corpora lutea.

They only occur in pre menopausal women.

11

What is the tumour marker which is tested for in ovarian Ca?

CA125

12

How do benign ovarian tumours present and how do you manage them?

May be symptomless or may cause lower abdominal pain in these scenarios just manage pain as most cysts will resolve spontaneously.

May present with acute abdomen in which cause manage with laparoscopy and send bloods for CA125

13

How do you manage ovarian cysts based on size?

If cyst is less than 5 cm and simple. Monitor with USS and consider doing CA125.

If persistent but still less than 5cm and simple: biopsy.

If cyst is greater than 5cm or is dermoid: cystectomy ai to prevent any spillage as this can cause chemical peritonitis.

If suspicious findings at laparoscopy take biopsy for diagnosis and refer to cancer centre for a full staging laparotomy.

14

What score is used to calculate post menopausal women's ovarian ca risk and how should they be managed spending on there risk?

Risk of malignancy index (RMI)

Low RMI: USS and CA125 follow up 4 monthly for 1 year is normal

Medium RMI: Bilateral oophorectomy.

High RMI: Refer to Ca centre for full staging laparotomy

15

In which group of women is ovarian Ca most common?

Post menopausal peak incidence is 75-84years.

16

What is the aetiology of ovarian Ca?

Irritation of ovarian surface epithelium by damage during ovulation.

17

What are the risk factors for developing ovarian Ca?

Null parity
Early menarche/late menopause
BRCA gene mutations
HNPCC gene

COCP decreases risk (stops ovulation)
Pregnancy decreases risk

18

What measure can be done to prevent the risk of ovarian Ca in women who carry the BRCA gene?

Prophylactic salpingooopherectomy

19

How do ovarian Ca present?

Initially vague may not present to later on.

Symptoms may include:
-Abdominal distension
-Early satiety
-Loss of appetite
-Abdominal pain
-Increased urinary frequency

20

Which factors make an ovarian mass more likely to be malignant?

Rapid growth greater than 5cm
Ascites
Bilateral masses
Appears solid on USS
Increase vascularity

21

How should you investigate suspected ovarian Ca?

Initial investigation:
CA-125 in all women over 50 with abdominal symptoms

If raised USS pelvis and abdomen if ascites or mass urgent referral to secondary care.

FBC, U/e's and LFTs

Secondary care:
If less than 40 AFP (alpha feta protein) and HCG used to identify those who have germ cell tumours.

RMI is calculated (US score, menopausal state, CA-125)

Full body CT

Other rare tumour markers can be tested for:
CEA (colorectal ca)
CA 19.9 (mucinous tumour)
Inhibin (granolas cell tumours)

22

What are the different stages of ovarian Ca?

1. Ovaries only
2. Spread to pelvis
3. Spread to abdomen and pelvis
4. Distant mets including liver

23

How is ovarian ca treated?

Surgery:
Diagnostic laparotomy followed by radical surgery.

Total abdominal hysterectomy, bilateral salpingoopherectomy, omentectomy, + lymph node removal.

Surgery followed up with chemotherapy. Monitoring is done with CA125.