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Lindsey's Blood and Lymph Unit III > Overview of Lymphoid Neoplasms/Hodgkin and non-Hodgkin > Flashcards

Overview of Lymphoid Neoplasms/Hodgkin and non-Hodgkin Flashcards

(65 cards)

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1
Q

____ is a T-cell marker that highlights abundant T-cells in the paracortex and scatter T-cells in the germinal center.

A

CD3

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1
Q

What is MCL?

A

B-cell neoplasm of small to medium-sized lymphocytes

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1
Q

What is MGUS?

A

monoclonal Ig in the serum or urine in pt w/o evidence of plasma cell neoplasms

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2
Q

In FL, the B cells will express _____, _____, _____, ____, and _____.

A

CD19, CD20, BCL2, CD10, BCL6

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3
Q

The ______ pattern is seen in BL.

A

starry-sky

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3
Q

What is solitary plasmacytoma of bone?

A

localized tumor of bone, composed of clonal plasma cells similar to those in plasma cell myeloma

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5
Q

What is BCL2?

A

an oncogene that induces follicular lymphoid hyperplasia

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5
Q

B-cells in MCL typically express ____, ____, and ____ but do not express ____.

A

CD19, CD20, CD5; CD23

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6
Q

What is Hodgkin’s Lymphoma?

A

4 types of germinal center B-cell neoplasms; Reed-Sternberg cells are diagnostic

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7
Q

The ____ deletion is the most common genetic alteration in CLL and has a favorable prognosis.

A

13q14

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8
Q

Translocations of the _____ on chromosome 8 at band 8q24 are a constant feature of Burkitt’s Lymphoma.

A

MYC oncogene

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9
Q

What is Burkitt’s Lymphoma?

A

highly aggressive B-cell lymphoma, presenting as extranodal sites or a leukemic form

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10
Q

MCL is characterized by the _____ gene rearrangement at _____, leading to a constant overexpression of cyclin D1.

A

BCL1; 11q13

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11
Q

CLL will have B-cells positive for ____, ____, and ____.

A

CD5, CD23, CD19

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12
Q

What does NSHL stand for?

A

nodular sclerosis CHL

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13
Q

What are the most frequent s/s of plasma cell neoplasms?

A

bone pain the back or extremities, weakness, tiredness, anemia

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13
Q

What does NLPHL stand for?

A

nodular lymphocyte-predominant Hodgkin’s Lymphoma

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14
Q

What are the 4 subtypes of Classical Hodgkin’s Lymphoma (CHLs)?

A
  1. nodular sclerosis classical Hodgkin’s Lymphoma 2. lymphocyte-rich classical Hodgkin’s Lymphoma 3. mixed cellularity classical Hodgkin’s Lymphoma 4. lymphocyte-depleted classical Hodgkin’s Lymphoma
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15
Q

What is cyclin D1?

A

it’s important in tumor development

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15
Q

Endemic BL can affect the ____ and _____ bones, and the _____, ____, and _____.

A

jaw; other facial; distal ileum, cecum, omentum

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15
Q

What is a Reed-Sternberg cell?

A

large, up to 100microm, multiple or lobated nuclei; ample cytoplasm

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17
Q

Efferent means ____.

A

away

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18
Q

What is a plasma cell myeloma?

A

bone marrow based, multifocal plasma cell neoplasm that shows M protein in serum or urine

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19
Q

What are the diagnostic criteria of MGUS?

A

M component less than myeloma levels; marrow plasmacytosis

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20
Tumor cells in HL express ____ and ____ but lack \_\_\_\_.
CD30, CD15; CD45
21
What does FL stand for?
follicular lymphoma
22
Where do 75% of all extraosseous plasmacytomas appear?
upper respiratory tract, including nasal passages, sinuses, oropharynx, and larynx
23
What is found in the 2a lymphoid follicle's mantle zone?
small cells that surround the germinal center
24
What is the average age of diagnosis of MCL?
60yo
25
Most plasma cell neoplasms originate as \_\_\_\_, but can occasionally present as \_\_\_\_.
bone marrow tumors; extramedullary sites
27
Most cases of FL have translocations of \_\_\_\_\_, which places BCL2 under the influence of the IGH promotor.
(14;18)
28
BL is endemic in the malarial belt of Africa, where the average age is _____ and involves the jaw or abdomen.
4-7yo
29
What are the Igs found in plasma cell neoplasms?
IgM (55%), IgA (20%)
30
\_\_\_\_ is a B-cell marker that highlights mantle zone and germinal center B-cells.
CD20
31
What do the lymph node sinuses contain?
lymphocytes, plasma cells, and histiocytes- usually patent
31
Translocations of the MYC oncogene on chromosome 8 at band ____ are a constant feature of Burkitt's Lymphoma.
8q24
32
\_\_\_\_\_ is highly aggressive but is potentially curable with aggressive therapy.
BL
34
What is FL?
lymphoma of germinal center B cells (centrocytes and centroblasts)
35
What cells are in the dark zone of the germinal center of a lymph node?
centroblasts
35
In \_\_\_\_, the malignant cells usually represent a small minority and contain Reed-Sternberg cells among inflammation.
Classical Hodgkin's Lymphoma (CHL)
35
What is the most frequent type of CHL?
nodular sclerosis CHL (NSHL)
36
Most cases of BL have the _____ translocation, which juxtaposes the MYC gene.
t(8;14)
37
What is the lymph node cortex?
where the follicles and paracortex are
39
Translocations of the MYC oncogene on chromosome 8 at band 8q24 are a constant feature of \_\_\_\_.
Burkitt's Lymphoma
41
In BL, the B-cells express ____ and ____ but are negative for \_\_\_\_, \_\_\_\_\_, \_\_\_\_\_, and \_\_\_\_.
CD19, CD20; BCL2, CD5, CD23, TdT
42
What is the least frequent subtype of CHL?
lymphocyte depleted CHL
43
What are the diagnostic criteria of solitary plasmacytoma of bone?
single bone lesions consisting of monoclonal plasma cells; absent of low serum or urine M protein
45
Afferent means \_\_\_\_.
towards
47
What cells are found in the lymph node medulla?
lymphocytes, plasma cells, macrophages, dendritic cells
48
What is extraosseous plasmacytoma?
localized plasma cell tumors that arise outside of the bone marrow
49
Translocations of the MYC oncogene on _____ at band 8q24 are a constant feature of Burkitt's Lymphoma.
chromosome 8
50
Where does NSHL frequently present?
above the diaphragm
52
What is the lymph node capsule?
thin, fibrous outer covering
53
What does MGUS stand for?
Monoclonal Gammopathy of Undetermined Significance
54
CD3 is a _____ marker that highlights abundant ____ in the paracortex and scatter ____ in the germinal center.
T-cell x3
55
CD20 is a ____ marker that highlights mantle zone and germinal center \_\_\_\_.
B-cell; B-cells
56
What is a plasma cell neoplasm?
clonal proliferation of immunoglobulin-producing plasma cells that secrete a single class of Ig, which is usually detectable as an M protein
57
What does MCL stand for?
mantle cell lymphoma
57
In contrast to other _____ that are usually indolent, MCL is moderately aggressive.
B-cell lymphomas
60
What does BL stand for?
Burkitt's Lymphoma
61
\_\_\_\_\_ is an indolent malignancy with popcorn or lymphocyte-predominant cells and reactive lymphocytes and histiocytes.
nodular lymphocyte-predominant Hodgkin's Lymphoma (NLPHL)
62
What are the 2 main subtypes of Hodgkin Lymphoma?
1. nodular lymphocyte-predominant Hodgkin's Lymphoma (NLPHL) 2. Classical Hodgkin's Lymphoma (CHL)
63
What cells reside in the lymph node paracortex?
T-cells
64
What cells are in the light zone of the germinal center of a lymph node?
mixed centrocytes, T-cells, dendritic cells, and histiocytes
65
In contrast to other B-cell lymphomas that are usually indolent, ____ is moderately aggressive.
MCL

Lindsey's Blood and Lymph Unit III (10 decks)

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