P and P1 Antibodies

Question 1

What type of antibody is Anti-P1?

Answer 1

IgM cold antibody, naturally occurring

Question 2

What kind of antibody is Anti-P?

Answer 2

IgG auto-antibody. This is the Donath Landsteiner biphasic antibody found in Paroxysmal Cold Hemoglobinuria.

Question 3

What cells does Anti-P react with?

Answer 3

Anti-P reacts with all P or P1 positive cells.

Question 4

What happens to the P1 antigen upon storage?

Answer 4

P1 antigen strength deteriorates upon storage.

Question 5

In regards to neutralization, what can you do with Anti-P1?

Answer 5

Anti-P1 can be neutralized to reveal other clinically significant alloantibodies.
(using Hydatid cyst fluid or pigeon egg whites)

Question 6

Where can P1 substance be found in the human body?

Answer 6

Hydatid cyst fluid.

> > in animals can also be found in pigeon egg whites.

Question 7

Which antibodies can be detected at immediate spin?

Answer 7

Any RT or cold antibodies: I, M, N, P1, Lewis (I may not pack lunch)

Question 8

What P antibody can cause spontaneous abortions and is also associated with Paroxysmal Cold Hemoglobinuria?

Answer 8

Anti-P