P H A R M A C O L O G Y | Basic

Question 1

Opioid receptor responsible for the shivering effect?

Answer 1

Kappa

Question 2

What receptor(s) is blocked by esmolol?

Answer 2

Beta-1

Selective for Beta-1 along with atenolol and metoprolol. Lower risk of causing bronchoconstriction

Question 3

What bolus dose of succinylcholine is required for a phase 2 block?

Answer 3

4mg/kg

Question 4

OIH can be prevented by what agents?

Answer 4

Morphine 0.1 - 0.25 mg
Ketamine

Question 5

Conditions associated with UPREGULATION of Acetylcholine Receptors

Answer 5

BURN
STROKE
SPINAL CORD INJURY
PROLONGED IMMOBILITY
PROLONGED EXPOSURE TO NMB
Multiple Sclerosis
GBS (Guillain Barre Syndrome)

Question 6

Conditions associated with DOWNREGULATION of Acetylcholine Receptors

Answer 6

Myasthenia Gravis
Anticholinesterase Poisoning
Organophosphate Poisoning

Question 7

PHYSIOLOGIC EFFECT OF PROPOFOL except:

Answer 7

decrease in CBF
increase in CPP
decrease in SVR
decrease in CMRO2

Question 8

The most potent form of KETAMINE is:

Answer 8

S+ form is most potent

It has half life of 2-3 hours and highly lipid soluble.
- The active metabolite is norketamine and is 1/3 as potent compared to the parent drug.

Question 9

When increasing the speed of onset of an NMB agents, utilizing 10% of its intubating dose. This is known as:

Answer 9

PRIMING