P4 +5 - Disorders of growth and neoplasia 2/3 Flashcards Preview

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Flashcards in P4 +5 - Disorders of growth and neoplasia 2/3 Deck (74)
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1

What are the 2 classifications of tumours?

1. Behaviour
2. Histogenesis

2

what are the 2 behaviours of tumours?

Benign v Malignant

3

what is the growth patten of benign tumours?

Expand and Remain localised
Typically well-circumscribed
Often encapsulated

4

what is the growth rate of benign tumours?

slower

5

what are the clinical effects of benign tumours?

local pressure effects: hormone secretion

6

what is the treatment for benign tumours?

local excision

7

what is the histology of benign tumours?

Resembles tissue of origin

8

what is the nuclei of benign tumours?

small, regular, uniform

9

what are the mitoses of benign tumours?

few, normal

10

what is the growth patten of malignant tumours?

Infiltrate locally, metastasize (spread to distant sites)

11

what is the growth rate of malignant tumours?

Faster

12

what is the clinical effects of malignant tumours?

Local pressure and destruction,
Inappropriate hormone secretion
Distant metastases

13

what is the treatment for malignant tumours?

Excision and additional therapy if metastases

14

what is the histology of malignant tumours?

Variable, many differ from tissue of origin

15

what is the nuclei of malignant tumours?

Larger, pleomorphic

16

what are the mitoses of malignant tumours?

Numerous, including abnormal forms

17

How can tumours be further classified?

-the cell type they resemble, ie their differentiation

-Most tumours resemble to some extent the tissue from which they arise

18

what is the benign tumour of covering epithelia?

papilloma

19

what is the malignant tumour of covering epithelia?

Carcinoma

20

what is the benign tumour of Glandular epithelia?

Adenoma

21

what is the malignant tumour of glandular epithelia?

adenocarcinoma

22

What are the benign tumours of smooth muscle, skeletal. muscle, bone forming, cartilage fibrous, blood vessels , adipose?

SM- leiomyoma
Skeletale muscle-Rhabdomyoma
BF- osteoma
C- Chondroma
F- Fibroma
BV- (Haem)angioma
A- Lipoma

23

What are the malignant tumours of smooth muscle, skeletal. muscle, bone forming, cartilage fibrous, blood vessels , adipose?

SM- leiomyosarcoma
Skeletale muscle-Rhabdomyosarcoma
BF- osteosarcoma
C- Chondrosarcoma
F- Fibrosarcoma
BV- Angiosarcoma
A- Liposarcoma

24

what may some highly malignant tumours be?

undifferentiated ie do not show any definite form of differentiation

25

Why does tumour type matter?

-Different tumour types behave in different ways
-Different benign tumours can behave differently
-Not all malignant tumours are equally malignant

26

What is the prognosis?

-Prediction of the probable course and outcome of disease

-Appropriate treatment and estimate survival

27

What does cancer prognosis include?

-Tumour Type
-Tumour Grade (Histology)
-Tumour Stage (Histology, Clinical, Radiological)
-Other Parameters (Patient ,Tumour)

28

What does knowing patterns of spread of tumour types aid?

diagnosis, staging and treatment

29

what is important anatomical knowledge to know for tumours?

Sentinal lymph node biopsy

30

what does tumour type influence?

How patients are investigated, treated and monitored