Flashcards in P450 Deck (9)
What is the major difference between pharmacodynamic and pharmacokinetic interactions?
Pharmacodynamic interactions are those involved with a drug (or drugs) and the target. Pharmacokinetic interactions are those that effects drug availability, including P450 clearance rates
Which interactions are predictable according to a drug's mechanism of action: pharmacodynamic or pharmacokinetic?
How often is a chief complaint related to a patient's drug regimen?
5% - not sure the number needs to be memorized, just know that these causes are common enough that you will see them on a regular basis
List 3 ways that a chief complaint can hint at being drug induced:
The wrong effect is observed, the effect is not proportional to the dose, or a symptom is not common to the patient's normal disease state
There are 5 major degradation products of acetaminophen (esp. overdose) listed below. Which is toxic? Treatment with NAC/glutathione breaks down the toxin into what metabolites from the list?
NAPQI, breaks down into Cysteine and Mercapturic acid
What drug metabolism process is non-P450 dependent? What nationality typically performs it quickly? Slowly?
Acetylation by n-acetyltransferase
Japanese - fast
Scandinavians - slow
What molecule is the driving force for most clinically relevant pharmacokinetic interactions?
What is the mechanism of a P450 inducer?
The inducing drug upregulates enzyme production in the liver