PADIS Flashcards

(37 cards)

1
Q

what is the PADIS team?

A

one of a few different poison centres across the country (5 now)
tox consultations across Canada
staffed by specially trained and certified healthcare professionals
- medical toxicologists
- tox fellows
- info specialists (pharmacists and RNs with subspecialty training)

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2
Q

PADIS roles

A
  • exposure to drugs, chemicals or toxins via any route possible
  • “I’ve done somhing I dont usually do”
  • “Have I taken too much? I’m concerned I poisoned myself”
  • “How can I prevent posioning?”
  • “I am caring for an overdose/poisoned patient and I want to review maanagment”
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3
Q

day to day activities of PADIS team

A
  • patient care (over telephone or bedside consulation)
  • education (gneral public and HCPs)
  • research/collab
  • surveillance (tracking trends/outbreaks)
  • prevention
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4
Q

toxicovigilance

A

the active process of identifying and evaluating the toxic risks existing in a community and evaluating the measures taken to reduce or eliminate them

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5
Q

toxicovigilance canada

A

antidote registry
reachback support
public outreach and communication
tox lab response network
Canadian surveillance system for poison info
situational awareness and early warning

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6
Q

risks of public health concern include poisoning outbreaks due to:

A
  • contamination
  • emergency use of new drugs
  • mass chemical exposures/terrorist events
  • unusual patterns or trends
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7
Q

1 drug PADIS sees

A

analgesis
- tylenol
- ibuprofen, etc.

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8
Q

2 drug PADIS sees

A

antidepressants
sedative/hypnotics/antipsychotics

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9
Q

non-drug exposures PADIS sees

A

household cleaning substances
cosmetics/eprsonal care producs
alcohols
foreignbodies/toys/misc
plants
chemicals
pesticides
fumes/gases/vapors
hydrocarbons
othr/unknown

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10
Q

majority of cases PADIS sees

A

unintentional and children
- only 1/4 intentional
- ingestion

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11
Q

telephone risk assessment

A
  • what is patient’s current clinical status
  • HPI = what did they take, when, intent, etc.
  • physical xam
  • initial investigations
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12
Q

toxic-specific questions in telephon risk assessment

A

what was ingested?
how much?
what was timeo f ingestion? staggered/all at once?
any coingestants?
access to toher meds?
any self-decontam events?
pill counts? how much was patient prescribed and when?
how has their clinical picture changed over time?

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13
Q

HEENT exam

A

head and neck exams
- pupils? = reactive, mydriatic, miotic
- rhinorrhea, secretions?
- temperature?

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14
Q

skin exam

A

flushed? dry? diaphoretic? discolered?

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15
Q

CNS exam

A

rigidity, spasticity?
clonus/hyper-reflexia?
altred mentation/delirium?
cerebellar signs?

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16
Q

GI exam

A

nausaea vomiting diarrhea?
ab pain? bowel sounds?

17
Q

CVS exam

A

evidence of pulmonary edema? injury?

18
Q

full set of vitals for tox exam

A

temp
glucose
HR
BP
RR
O2 sats
GCS
= what has the trend been?

19
Q

process of preventing systemic absorption into the body

A

decontamination
- SDAC (charcoal), gastric lavage (stomach pump), WBI

20
Q

process of speeding up metabolism and elimination of an already absorbed substance

A

enhance elimination
- can be ex- or in-vivo
- hemodialysis, MDAC, urinary alkalinization, intra-lipid (IV fat emulsion)

21
Q

what is the difference between fever and hyperthermia?

A

fever = normal response of body; changes body thermometer to drive up inflammatory cascades

hyperthermia = thermometer broken and body cannot generate heat; generation of heat comes from external sources; DEADLY

22
Q

this controls temp and muscle hyperactivity (H&B pt)

A

sedation
benzos!!!
also consider intubation and paralysis

23
Q

what should be done aout elevated temperature?

A

tylenol??? NOOOOOO
not if thermometer is broken ; do other things to cool patient down

24
Q

when do we stop cooling? what are our targets?

A

<39 C within 20 to 30 mins
this is a TRUE emergency

25
how to aggressively cool hyperthermic patients?
chemical sedation helps (benzos, etc.) also: - body bag + ice/water - fanning and misting - exposure - cooled (4C) IV fluids - cool packs to the axilla, groin, neck (major blood vessel highways) - further sedation and paralysis
26
ilicit opioids contain numerous adulterants
sulfonylureas = anti-diabetic pt = prooud hypoglycemia for days baking soda xylazine = horse tranquilizer causes a much more altered pt...
27
symptoms of opioid ingestion
drowsy, somnolent pinpoint or miotic pupils bradycardiA and hypotensionn bradypnea, hypopnea hypoxia (decreased O2) hypercarbia (increased CO2)
28
this completely reverse effects of any opioids
naloxone
29
RRSIDEAD
resuscitation risk assessment supportive care investigations decontamination enhances elimination antidotes disposition
30
what is included in a tox panel?
CBC + Diff electrolytes and extended lytes creatinine, urea, eGFR VBG/ABG with co-oximetry, lactate ASA, EtOH, actaminophen serum levels, serum osmoles (accessible and have antidotes) LFTs and transaminases ECG = QRS, QTc +/- CXR
31
urine tox screens
rarely helpful in acute management of tox patients
32
urine drugs of abuse can be used to screen or **qualitatively** test for:
- amphetamines barbiturates benzos cocaine cannabinoids opiates (fentanyl not picked up) oxycodone methadone, etc.
33
the process of preventing systemic absorption into the body
decontamination ex: SDAC, gastric lavage, WBI
34
enhanced elimination
process of speeding uo metbaolism and elimination of an already absorbed substance can be ex-vivo o in-vivo - hemodialysis, MDAC, urinary alkalinization, intra-lipid (IV fat emulsion)
35
toxicology of hot and bothered pt
sympathomimetics anticholinergics serotonergic (serotonin syndrome) antipsychotics (neuroleptic malignant syndrome) ETC uncouplers (ASA, DNP) drugs that predispose to ppor environmental responses malignant hyperthermia
36
hot and bothered patient non-tox causes
infectious structural endo/metabolic environmental
37
Kratom
tropical evergreen native to SE Asia ingestion = stimulant and opioid effects - has been touted as a treatment for opioid withdrawal but no evidence supporting this