Pain

Question 1

Paracetamol prim mech

Answer 1

mild COX-2 inhibition
increase activation of cannabinoid receptors, by increasing endogenous endocannabinoid reuptake
possible 5HT3 Receptor activation to activate desending serotonergic pathways

Question 2

what can paracetamol overdose lead to?

Answer 2

OVERDOSE:
Liver damage and less frequently renal damage.

Nausea and vomiting early features of poisoning (settle in 24h).
Onset of right subcostal pain after 24hindicates hepatic necrosis.