Pain

Question 1

fast pain has __ fibers?

it associated with the __ tract

Answer 1

A Delta- type 3

neospinothalamic tract

Question 2

fast pain Release __ at dorsal horn synapse

Answer 2

glutamate

Question 3

Mediated primarily by __ fibers

it is associated with the __

Answer 3

C (type 4)

paleopinothalamic tract

Question 4

Glutamate acts through __ channels. The most popular glutamate channel/receptor is the __

Answer 4

IONOTROPIC

NMDA

Question 5

slow pain Release __at dorsal horn synapse

Answer 5

Release Substance P at dorsal horn synapse

Question 6

skin mechanoreceptors

Answer 6

Meissner’s corpuscles
Fine touch

Pacinian corpuscles
Vibration

Merkel receptors
Pressure/texture

Ruffini endings
Skin stretch

Free nerve endings
Hair follicles
Nociceptors
Thermoreceptors

Question 7

free nerve endings are Widespread in

Answer 7

superficial layers of the skin, periosteum/cranium, arterial walls, joints

Question 8

nociceptors have sensory adaption

T/F

Answer 8

False

Question 9

nnociceptors : mechanical vs chemical stimuli

Answer 9

mechanical
lack of specialized endings 	raises threshold
 may be somatic or visceral
disrupting membrane (stretching it) or cell and it causes flow of ions in 

chemical:
exogenous and endogenous algesic factors
may be somatic or visceral
HCl spilling on skin or HCl getting out of GI tract: both=pain

Question 10

nociceptors: thermal stimuli

VS itch/ tickle

Answer 10

thermal:
heat : > 43ºC (113ºF)
cold: < 15ºC (59ºF)
usually somatic

itch/tickle:
associated with nociceptors
travel in spinothalamic pathway