Pain (Chapter 7) Flashcards

(64 cards)

1
Q

how can fast pain be described ?

A

sharp, prickling, acute, electric

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2
Q

how can slow pain be described ?

A

burning, aching, throbbing, nauseous, chronic

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3
Q

how is pain initiated ? where can it be found ?

A

initiated by free nerve endings in superficial layer of the skin
also found in internal tissues (periosteum, arterial walls, joint surfaces, falx, tentorium of the cranial vault)

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4
Q

explain pain in deep tissues

A

they dont have pain nerves, but overall pain can give the impression of pain in these areas

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5
Q

what is periosteum ?

A

the membrane that lines the outer surface of bones

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6
Q

what is falx

A

part of the dura mater of the cranium

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7
Q

what is the tentorium cerebelli ?

A

extension of dura mater separating the cerebellum from the inf portion of occ lobes

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8
Q

what are the 3 types of stimuli that pain is initiated by ?

A

mechanical, thermal, chemical

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9
Q

what is fast pain initiated by? which type of stimuli

A

mechanical and thermal

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10
Q

which type of stimuli initiates slow pain ?

A

mechanical, thermal, chemical

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11
Q

name seven causes of chemical pain

A
bradykinin
serotonin
histamine
potassium ions
acids
ach
proteolytic enzymes
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12
Q

what is pain enhanced by ? how ?

A

prostaglandins and substance P

they make the nerve endings more sensitive

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13
Q

explain the adaptation mechanism of pain receptors

A

they are non-adaptable

continue to deliver pain signals and may in fact lead to greater pain sensitivity called hyperalgesia

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14
Q

what is the correlation between pain and tissue damage?

A

positive

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15
Q

what degree celsius is when tissues start to be damaged ?

A

45

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16
Q

following tissue damage, what is the number one responsible chemical for pain ?

A

bradykinin

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17
Q

in a painful area, what will you find local increases of ?

A

potassium ions and proteolytic enzymes because they directly attack nerve endings due to increased ion permeability

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18
Q

what is ischemia ? how does it cause pain

A

blocked flow

causes pain through buildup of lactic acid from anaerobic metabolism + bradykinins and proteolytic enzymes

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19
Q

what is bradykinin ?

A

a small peptide that is a physiologic mediator of pain

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20
Q

what is the neospinothalamic tract ?

A

fast pain transmitted from peripheral nerves to spinal cord by small type A delta fibers
velocity of 6-30 m/s
terminates in brain stem and somatosensory cortex

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21
Q

what is the paleospinothalamic tract ?

A

slow pain transmitted to spinal cord by C fibers at 0.5-2m/s terminating in spinal cord

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22
Q

explain the dual system of pain

A

the two tracts, slow and fast, work together
initial fast response makes person react quickly
second slow response makes person respond over time to alleviate the situation

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23
Q

how many pain tracts are there ?

A

2 except 3 in higher mammals

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24
Q

what are 5 non-drug ways of dealing with pain ?

A

1- transcutaneous electrical nerve stimulation
2- manual acupressure
3- endogenous opioids (innate)
4- surgical interruption (cutting of pain nervous pathways by cordotomy in thoracic region of spinal cord) spinal cord on side opposite to pain is partially cut in anterolateral quadrant to interrupt the anterolateral sensory pathway
5- acupuncture

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25
does acupuncture work ?
small analgesic effect, but cannot clearly be distinguished from bias
26
what is the idea behind acupuncture ?
penetration of skin results in release of endogenous opioids
27
what is a drug that treats pain called ?
analgesic
28
what are analgesics to treat mild pain ?
tylenol, NSAIDs, caffein mixtures (OTC)
29
what are analgesics to treat severe pain ?
prescription opioids
30
what are the three most important opioid receptors in the CNS ?
mu kappa delta
31
what do opioid receptors do ?
mediate natural analgesic effects in response to endogenous b-endorphins
32
how do opioid drugs work ?
inhibit synaptic transmission in CNS | also decrease substance P transmission across cleft
33
where is the mu opioid receptor found ?
in pre- and post-synaptic membranes of pain
34
explain how opiods inhibit substance P
hyperpolarization occurs, harder to get AP need more substance P to depolarize the nociceptor reduces conduction along afferent nociceptor
35
what is morphine ?
strongest opioid analgesic | decreases pain through opioid receptors and decreases perception of pain
36
how is morphine most effective ?
parenterally because GI absorption unreliable
37
what is codeine ?
metabolizes into morphine, decreasing pain through opioid receptors
38
what can codeine be used with ?
aspirin, acetaminophen, caffeine
39
what is hydrocodone ?
stronger derivative of codein
40
what is vicodin ?
hydrocodone acetaminophen mixture
41
what happens mixing hydrocodone with caffeine ?
becomes pain and sinus medication, clearing nasal passage
42
what is oxycodone (oxycontin)
not as strong as morphine has controlled release has an abuse potential
43
what is methadone ?
mildest type of opioid, treating cancer patients and addictions
44
is caffeine an analgesic ?
not by itself, but makes opioid effects last longer (synergist)
45
how do opioids effect cough ?
suppresses cough center in medulla , which is why codeine used in cough medicine
46
how do opioids affect the GI tract ?
decreased GI mobility,constipation
47
how do opioids affect pupils ?
myeosis (pupil constriction)
48
how do opioids affect peeing ?
urinary tension, feeling of wanting to pee but can't
49
how do opioids make you dizzy ?
orthostatic hypotension
50
how do opioids change state of mind ?
a side effect could be dysphoria
51
what are contraindications to opioids ?
monoamine oxidase inhibitors (antidepressants) | can lead to death
52
what are the advantages of local anesthetics ?
do not cause loss of consciousness even with parenteral administration
53
how can local anesthetics lead to coma ?
CNS depression
54
how are local anesthetics often used ?
parenterally by infiltration anesthesia (injection at area where anesthesia is desired) or nerve block anesthesia (injection near nerves supplying a specific area)
55
what does the duration of anesthesia depend on ?
the lipid solubility of anesthetic, amount of blood flow at site of injection more blood flow carries the drug away from the site quicker
56
what do anesthetic names end with ?
-caine
57
what are examples of topical anesthetics ? what are they used for
pain relief on skin surface or mucous membranes sprays, gels, lozenges, suppositories
58
what is special about topical anesthetic ethyl chloride ?
effectiveness as the result of a cooling effect (like ice but much quicker) spray on skin until skin turns white in 5 seconds duration of response seconds to a minute
59
what is the only local anesthetic that is a controlled substance ?
cocaine
60
what is cocaine used for and how ?
topically got anesthesia of ear, nose, and throat
61
how is cocaine unique ?
causes constriction of local vasculature and eliminates the need for using epinephrine absorbed by mucous membranes and has more pronounced CNS effects, stimulatory effects first and then depressant effects
62
how does cocaine affect HR and BP
small doses: bradycardia | big doses: tachycardia and hypertension
63
what are the two main groups of analgesics ?
NSAIDs/ acetaminophen opioids
64
what is the main concern when prescribing opioids as analgesics ?
constipation | recommend laxatives