Pancreatic Cancer Flashcards Preview

Clin Med 2 > Pancreatic Cancer > Flashcards

Flashcards in Pancreatic Cancer Deck (12):
1

Functions of pancreas

Exocrine- digestive enzymes
Endocrine- islet cells involved with blood sugar regulation

2

RF pancreatic cancer

- chronic pancreatitis
- smoking
- DM
- family history of global malignancy

3

Clinical

- painless jaundice
- unintentional weight loss
- recent onset of atypical DM
- palpable mass (late stage)
- ascites (late stage)
- courvoisier's sign

4

What is courvoisier's sign?

non-tender palpable gallbladder with jaundice

5

Labs

LFT- increased and bilirubin increase if bile can't get out
CA 19-9 (pancreatic cancer tumor marker)

6

Imaging

- Start with ultrasound to look at biliary system
- then do CT
- MRI is best imaging modality
- Endoscopic ultrasound lets us look at pancreas, biopsy the tumor and look at the lymph nodes around

7

Tx

- only curative approach is surgery
- stage 1 to 2b is most likely to be cured by radical resection
- do a whipple if tumor in head of pancreas
- distal pancreatectomy is tumor in body or tail
- chemotherapy

8

What is a whipple?

1. resection of head of pancreas
2. excise the duodenum and bile duct
3. reconstruction with intestine

9

What is a majority of primary pancreatic cancer?

ductal adenocarcinoma

10

Where do most cancers arise?

head

11

When most pancreatic cancers discovered where are they found?

metastasized to peripancreatic lymph nodes

12

Where does pancreatic cancer metastasize to?

live
peritoneum
lung and pleura
adrenal glands