Pancreatic disease Flashcards
Which two hormones stimulate the pancreas?
Secretin and CCK
Where is secretin produced
S cells of duodenum
What does secretin do?
Controls gastric acid secretion and buffering with HCO3
What does CCK do?
Stimulates fat and protein digestion
Where is CCK produced?
I cells of duodneum
CCK and secretin role summary
CCK - digestive enzymes
Secretin - gastric acid secretion
Besides alpha cells and beta cells, what other cells are in the islets of Langerhans?
Delta cells
D1
PP
Besides alpha cells and beta cells, what other cells are in the islets of Langerhans?
Delta cells
D1
PP
What do delta cells do?
Produce somatostatin which regulates the above
What does D1 do?
D1 is a vasoactive peptide which stimulates secretion of water into pancreatic system
What is PP
Pancreatic polypeptide self regulates secretion activities
What is metabolic syndrome?
A collection of conditions that increase the risk of ischemic heart disease
Fasting hyperglycemia above 6mmol/L
BP above 140/90
Central obesity >94cm in M, >80cm in F
Dyslipidemia - decreased HDL cholestrol and increased TGs
Microalbuminemia
Acute pancreatitis histology
Coagulative necrosis
What hormone is sensitive for pancreatitis?
Serum lipase
What kind of cancer cells are cholangiocarcinomas? What are they associated with?
Adenocarcinomas, gall stones
