Pancreatic Disease Flashcards
What are the typical histopathological changes observed in a) acute and b) chronic pancreatitis
a) Oedema, neutrophilic infiltrate, necrosis
b) Fibrosis
Which breeds are predisposed to chronic pancreatitis?
CKCS, Cocker Spaniels, Boxers, Collies
What infectious disease has been associated with AP?
Babesiosis
In a necropsy study of 200 dogs, how many had a) macroscopic and b) microscopic signs of pancreatitis?
a) 8%
b) 30%
What is the sensitivity/specificity of total lipase for canine pancreatitis?
50/50
What is the effect of experimentally induced CKD on CPLi in dogs?
Increases but usually not above RR
Which drugs have been associated with pancreatitis in dogs?
KBr, Phb, Ca++, L-asparaginase
What were the findings of a study comparing enteral and parenteral nutrition in dogs with AP?
No difference in mortality
Faster recovery in dogs fed enterally
What is the MOA of maropitant?
NK1 inhibitor - blocks substance P
What is the MOA of ondansetron?
5HT3 antagonist
Which breed of dog has been reported to have chronic pancreatitis with features of autoimmune pancreatitis?
Cocker Spaniel
What are biochemical indicators of severe pancreatitis in cats?
Hypoalbuminaemia and hypocalcaemia
Why is dietary fat restriction NOT recommended in cats with pancreatitis?
They have a high constitutive requirement for arachidonic acid
What are the most common causes of EPI in dogs and cats?
Chronic pancreatitis (dogs and cats)
Pancreatic acinar atrophy (dogs)
What breeds of dog are affected by pancreatic acinar atrophy?
GSD, rough-coated Collies and Eurasians
